Understanding The Dexamethasone Suppression Test

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A simple explanation of why you would do a dexamethasone suppression test and how to interpret the results.
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DISCLAIMER: This video is for education and entertainment only, and is not medical advice. This video should NOT be used for medical advice or to guide clinical practice. The Zero to Finals content should not be used in any way to guide medical decision making. Zero to Finals takes no responsibility for any actions taken or not taken based on the information provided. Local and national guidelines and senior clinicians are there to help you make decisions, not RU-vid videos. If you need medical advice or information, seek it from an appropriately trained and licenced doctor or healthcare provider that can address your individual needs. Zero to Finals cannot guarantee the accuracy of information in this video. Please highlight any errors you notice in the comments below - thank you.

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3 авг 2024

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Комментарии : 342

@chrisnjoku2777 3 года назад

Who is here after watching this video some months back and feeling like they have 'finally' understood the DMST and will never forget it only to come back to watch it again.

@ZeroToFinals 3 года назад

haha! I made the video and I still have to come back to remind myself. It is a tricky topic

@saleemullah4991 3 года назад

🖐️🖐️

@qwertyuioparya 3 года назад

@alviyt6627 Год назад

I am here for the same reason 😂

@iknowthatiknownot 6 месяцев назад

@lawyerdoctor 3 года назад

Brilliant. You explained this test 100% better than the pharm professor at my medical school. I was confused and now I understand, thank you!

@amandamccrary9773 5 лет назад

I really couldn't get this through my head until now. Thank you.

@ZeroToFinals 5 лет назад

glad to help!

@rmacd Год назад

I've gone through 3 years of medical school and it's literally taken me this video for everything to click into place

@billkuo1 5 лет назад

My notes on steps with dexamethasone suppression test (with Fahad's input) • 1 mg of dexamethasone (low dose suppression test) is given at 10pm at night and blood levels of cortisol and ACTH are measured at 9am next morning • If the person have normal CRH-ACTH-cortisol function, ACTH would be suppressed via negative feedback • low ACTH -> low cortisol • Blood test would show low cortisol • If blood test show normal or elevated cortisol levels, it indicates Cushing syndrome, ACTH should then be measured (note: measure cortisol first because measuring ACTH first cannot rule out Cushing syndrome) • If Cushing syndrome is caused by primary causes, Cortisol would remain high, but ACTH will react to suppression ie. Low ACTH in adrenal adenoma, or exogenous steroids • If syndrome is caused by excess ACTH: Cushing disease (pituitary adenoma), or ectopic ACTH in paraneoplastic syndromes in SCLC, ACTH will remain high or normal • In this case, high dose suppression test is used where 8mg of dexamethasone is given at 10pm and ACTH is measured next morning • High dose dexamethasone is able to suppress ACTH release from the pituitary, therefore, low ACTH would mean pituitary adenoma / Cushing disease (cortisol would be low as well because ACTH is low) • ACTH remaining high would mean it is not released at the pituitary, and ectopic ACTH would be likely

@joleneong8173 2 года назад

you are a legend!! this saved my life!!

@zwenyinyihtun6988 2 года назад

The best one

@Callmeperrys Год назад

Finally after years of studying this I get it

@trafficjon400 10 месяцев назад

Dexamethasone tortured my life for over 6 years now? 1 injection for Swelling from a product effected my adrenal Cortisol very badly by still shaking while waking and told my cortisole is sopposed to react with waking but is not. it takes the life out of a person and waking in hell . if your a believer in God dexamethasone will take the belief away for sure when you feel like your in hell unexplainable. ENDOCRINOLOGIST i dare not to see because they don't really know the correct levels of treating with this hormone. Any body abused and have emotional problems better keep far from Steroids Corticasteroids that induce PTSD or any kind of fear will be doubled in Severity.

@davidoconnor4028 4 года назад

made everything so much clearer, thank you

@meliketopaloglu3308 3 года назад

Oh wow, you are making everything so easy , thank you so much, I did not even have internet during my medical school , I wish I had and watched you 🙌🏼

@s101077 3 года назад

🙌🏼

@amymunro1419 3 года назад

This is such a great explanation of the test - thank you!

@krisshassebrock7518 5 лет назад

Finally I'm getting the answers to my questions!! Thank you so very much

@ZeroToFinals 5 лет назад

No problem, glad to help Kriss

@leenahmed147 Год назад

The summary at the end was so helpful, Thank you!

@abifarinopeyemi1688 Год назад

This was broken down to bits and really helpful. Thank you.

@ZeroToFinals Год назад

Glad it was helpful!

@Shubham-td9yz 3 года назад

This was easy to understand.... thanks for making it crystal clear 😇

@jehangiri6 5 лет назад

Once the Low Dose Dexamethasone Suppression Test is positive , the next step is to measure Serum ACTH levels , if the are low , its either exogenous steroid (most common cause) or Adrenal adenoma , you do not need to do High dose suppression in this situation. However if Serum ACTH is high after a positive low dose suppression , then you do High dose suppression test to determine whether its Cushing Disease (Cortisol Suppressed) or Lung Cancer(Cortisol Unchanged ). I like your channel though , from Pakistan.

@ZeroToFinals 5 лет назад

Thanks for your comment Fahad. You are right!

@faisalhaqparast357 5 лет назад

Now i understood from your comment

@LostSmiler 4 года назад

legend man. Thanks

@adamjohnzon 2 года назад

very helpful, thanks!

@fahadafridi8173 2 года назад

sher ye sher

@iqrakanwal6438 4 года назад

Best explanation of Dexamethasone Suppression Test I have ever come across. Cheers.

@ZeroToFinals 4 года назад

Wow, that great feedback!

@reemabdelhay3497 2 месяца назад

Amazing video.. I can’t believe that I understand it finally.. lots of love and support.. keep up the good work 🎉❤

@funmiade575 5 лет назад

I am truly enjoying these videos. Thank you so much.

@ZeroToFinals 5 лет назад

Thanks again. I'm going to keep making them!

@user-sw6hl1dd2x 2 года назад

I just cant really believe l understood it specially after all these years of graduation.. Really thank u so much

@amanchauhan7934 3 года назад

Simple, to the point and perfect

@preeshillashibchurn3847 5 лет назад

Finallyy a video that helped me to understand DMST.. thank you..very helpful😊

@ZeroToFinals 5 лет назад

no problem Preeshilla, glad you liked it!

@KrissAstronomist 7 лет назад

A great explanation, thank you!

@champikasam 5 лет назад

Thanks for the detailed explanation. keep up the good work!

@ZeroToFinals 5 лет назад

Will do!

@deevanshirathore2730 3 года назад

Thank you so much, was super confused and now all clear mind, thank you

@marcotayala 7 лет назад

Nice vídeo, very interesting and educational. Now I understand better this system.

@muhammadyaqoob877 3 года назад

Your way of teaching is outstanding

@ZeroToFinals 3 года назад

Thank you!

@lightadetoun796 Год назад

Wow! As clear as you cam ever have it!!! Brilliant 👍. Thank you very much

@stalinthomas8187 3 года назад

Simplified the test in a beautiful way.... Congrats

@ZeroToFinals 3 года назад

Thanks!

@Bambii348 4 года назад

Thank you, made it so easy to understand!

@adissabooz7131 7 лет назад

Muchas gracias, súper práctico y explícito!!! I like it

@robinhall3426 7 лет назад

Excellent video and explanation!

@sameeragunasekara2785 4 года назад

Nicely & simply explained 👍thank you

@Dj2anime 7 лет назад

Awesome explanation! It was simple and easy to follow - I can actually wrap my head around it now :D

@kmysl2219 3 года назад

Perfect explanation. Thank you!

@keanutax4951 5 лет назад

This is a very good and simple video, thanks!!

@ZeroToFinals 5 лет назад

Thanks Keanu!

@Wanos-zw9sf 2 года назад

OmG thank you sooooo much I was dying with this test .. you r my hero . Thanks alot

@kyizinthant6097 5 лет назад

Thank u. You make it easier to understand. ❤️

@ZeroToFinals 5 лет назад

Thanks, I'm glad to have helped

@abdulazizalhowaish2692 4 года назад

Thank you for the video, it's very helpful to understand the dexamethasone suppression test.

@ZeroToFinals 4 года назад

glad to help!

@safayounis2762 4 месяца назад

Awesome video, helpful and to the point! thank you

@SBASAK25071996 Год назад

amazing!! understood at one go! brilliant teaching❤

@ayameziane2172 2 года назад

tysm for this amazing clear explanation !!

@ikhlas9569 3 года назад

Thank you sooooo much!!!! very well explained!!

@reemsulaiman6796 3 года назад

this video saved my life. thank you so much

@trafficjon400 3 года назад

Steroid Dexamethisone put many in a dark place of sevier Depression. a very nice Girl on You tube is still suffering from this 4 years and suicidal. Cushings and all the symtems these horible steroids can cause.

@wafawiwi460 5 лет назад

this was very helpful thank you

@AhmedHassan7807 4 месяца назад

Thank u so much. Finally, I understood it.❤❤

@34.muhammadhusnulhakimibin76 2 года назад

''Wah thank you, already include the summary in my slide this week for my presentation on pituitary gland pathology to my beloved students from Malaysia'' -Dr. Asawari Sant.

@Arpit4063 6 лет назад

Very comprehensive video. 👍

@NehaShaikh21 3 года назад

Thank you so much Really couldn't get it until now

@felipevergara4894 4 года назад

Thanks you very much, very clear your video, it help to understand very good diferents tests, cheers from Arngentina.

@biiiaNcaXD 2 года назад

Thanks for this! Great video!

@mycah1993 6 месяцев назад

Thank you! You're the best!

@muhammadwali203 3 года назад

Awesome explanation!

@jaredwainwright4621 4 года назад

what a wonderful video. this med student thanks you

@TahmidRahman 4 года назад

Really good explanation !

@almostawhisper1990h Год назад

Very helpful! Thank you so much ❤

@inaduttagupta5747 Год назад

Made me understand so well ❤

@sashwattarenia258 6 лет назад

excellent explanation

@hichembennaoum8871 5 лет назад

that guy is my new superhero ! ..god bless u !

@ZeroToFinals 5 лет назад

awesome!

@chogabykyu 3 года назад

Thank you so much for this.

@GujjuDoctor 5 лет назад

YOU are amazing. Thank you. Love From INDIA :)

@dewisartika9990 3 года назад

thank you so much, so helpful!!

@hanhane0 4 года назад

thank you so much for this! really helpful

@ZeroToFinals 4 года назад

Glad to help

@darkmoon3646 2 года назад

Thankyou man, may god bless u!

@ak3143 2 года назад

great explanation, thank you!!

@fatimab6064 6 лет назад

Thank you great job!

@moeyousef9006 Год назад

thanks for the video it was really helpful

@wobbyyy 2 года назад

Thank you for this video!

@lukwagonicholas1305 6 месяцев назад

Thank you Dr. Tom.

@reznof2011 4 года назад

What a lovely explanation

@ZeroToFinals 4 года назад

thanks johnny!

@sadiasiddiqi6011 7 лет назад

Great job!

@Hichamnostik_YT 3 года назад

Love your explanation thank you ❤️

@ZeroToFinals 3 года назад

Thanks! I'm glad it helped

@As-ht5rw Год назад

Crystal Clear. Thank you. When I saw over 7min I skipped to a shorter video...then to another shorter video then..... another shorter video as. I have not clearly been convinced that I understood it... So I went back to your video.... I would have saved time by listening to my gut feeling and just watched your video. It was crystal clear. Thank you.💌