VDJ recombination overview | Generation of antibody diversity | Antibody diversity mechanism | VDJ

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This video gives a birds eye view on VDJ recombination and generation of antibody diversity.
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29 июл 2024

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Комментарии : 86

@Science_afterhours 5 лет назад

I'd like to thank you for this - I'm doing a MSc in Immunology and the textbook explains this process poorly in my opinion. So have saved me hours of confusion.

@animatedbiologywitharpan 5 лет назад

Great to hear that you found it useful

@tioadekola-ojo363 3 месяца назад

Very informative video. Was able to better understand antibody diversity for my upcoming exam tomorrow, thank you!

@animatedbiologywitharpan 3 месяца назад

quickly share with all of your friends

@kamnagupta2234 3 года назад

This helped so much! Current med student in the US-thanks!

@animatedbiologywitharpan 3 года назад

Please share my channel link with your classmates and help ke to reach big audience

@animatedbiologywitharpan 3 года назад

Dont forget to check out the immunology playlist...most important topics are covered via animation

@rashmiranjansahoo3975 4 года назад

I have read that human contains 44 variable gene segments on heavy chain and u say 57.Can u justify it.

@cck09 3 года назад

Great 👌☺️👍

@aminajoliedaou9844 8 месяцев назад

🥹🥹thank you for your explication you saved my life ❤️❤️it’s so much clear right now in my head

@animatedbiologywitharpan 8 месяцев назад

Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.

@pooh708 5 месяцев назад

Complete information in just 11 minutes❤❤❤

@animatedbiologywitharpan 5 месяцев назад

Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.

@matteobarca1050 4 года назад

Thank you, I finally understood it. Just a question, when you say there is a Flexibility that generate a lot of variability, you mean there are several points in which RAG1and2 could operate? Thanks a lot and a big hug from Italy

@animatedbiologywitharpan 4 года назад

Matteo Barca good question I would make a separate video for that....stay tuned and please share my channel link with your friends

@matteobarca1050 4 года назад

It's a easy question about this video, It's like a yes or no

@sanshi7 Год назад

@@matteobarca1050 "Junctional diversity occurs because the RAG1/2 recombinase makes a covalent hairpin at the coding end. Because the hairpin can be opened at any location near its end, this can result in a random loss of a small number of nucleotides at the coding end, or the gain of a few base pairs from the opposite strand that is now covalently linked to the coding end. These latter nucleotides are called “P” nucleotides because they are palindromic to the coding end. In addition, tremendous diversity is added to the junctions by the nontemplated addition of nucleotides to the coding ends by terminal deoxynucleotidyl transferase". from - Molecular Biology of B Cells (Second Edition), 2015. I hope this helps.

@milocrawford5506 3 года назад

Thank you man, for real, I was having a breakdown hear because I couldn't understand shit about VDJ lol

@animatedbiologywitharpan 3 года назад

Please share my channel link with your friends and help me to reach big audience

@nithya_2003 5 месяцев назад

Thank youuu!! 😊

@animatedbiologywitharpan 5 месяцев назад

could you please share my channel link with your friends ?

@nithya_2003 5 месяцев назад

@@animatedbiologywitharpan Sure!

@tanmoysen7368 5 лет назад

Dada, if you do videos on specific section and make playlist of those videos just like you had done on CELL SIGNALLING that will be very helpful for us inspite of overview videos ....specially for people like me ( did not get much help from teachers)... I hope you will look into this request ....and keep doing amazing videos like this ...

@animatedbiologywitharpan 5 лет назад

I will upload more over time....but I think my overviews are pretty detailed as well

@animatedbiologywitharpan 5 лет назад

Share among friends and also you can suggest your topic...I would upload sometimes if I can

@tanmoysen7368 5 лет назад

Hya dada ,my friends thoroughly follow you including me. You are our inspiration. As We are in final year of BSc biotech it will be very helpful if you upload videos related to RDT

@aminajoliedaou9844 8 месяцев назад

With pleasure 🥰

@animatedbiologywitharpan 8 месяцев назад

Thanks a lot. Love from India

@debabratalaik9296 4 года назад

Amaaaazing

@animatedbiologywitharpan 4 года назад

Share among your friends and help me to reach big audience

@samarthkumar5198 3 года назад

In which segment of Variable region CDR's are present?

@animatedbiologywitharpan 3 года назад

Near the N terminus

@charliebrett7510 Год назад

Hey! where exactly does this take process take place with respect to chromosomes. I get it takes place in developing B cells. Also for context we get 23 chromosomes from each parent and VDJ happens at specific chromosomal loci AND chromosomal DNA is double stranded. So my question is does this process take place on one chromosome pair or just on a singular chromosome? Also must these chromosomes be replicated prior to VDJ recombination? Thanks so much

@animatedbiologywitharpan Год назад

The immunoglobulin heavy locus on chromosome 14, containing the gene segments for the immunoglobulin heavy chain. So its happening in chr 14 in human.

@charliebrett7510 Год назад

@@animatedbiologywitharpan Thanks so much for the reply but could you please clarify whether this is on a single chromosome 14 locus (one copy) or pair of chromosomal 14 loci?

@angelsvasquez8353 Год назад

@@charliebrett7510maybe you can find it in Internet

@jayanthijayaraman1995 3 года назад

Excellent presentation will be helpful if heavy chain gene rearrangement is presented in Vol. II

@animatedbiologywitharpan 3 года назад

Yup I would do a detailed video on that (starting with the work of Susumu Tonegawa)

@simple_pharmacology 3 года назад

Thank you so much its very helpful

@animatedbiologywitharpan 3 года назад

Please share my channel link with your friends and help me to reach big audience

@simple_pharmacology 3 года назад

@@animatedbiologywitharpan ok my friend 👌👋👋

@alperenaslan9332 3 года назад

awesome. Hello from turkey

@animatedbiologywitharpan 3 года назад

Please share my channel link with your friends and help me to reach big audience

@ArthySuresh 4 месяца назад

Thank you, very well explained:)

@animatedbiologywitharpan 4 месяца назад

please don't forget to checkout entire immunology playlist ru-vid.com/group/PLKtiwIJ8Q7rq77W7r4cXPrbhi_VpLWw8c&si=-mC4nHbVhiflO4_F

@animatedbiologywitharpan 4 месяца назад

Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.

@debabratalaik9296 4 года назад

But which book you are following for b cell signalling ??

@animatedbiologywitharpan 4 года назад

ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-Ay28l_Ind0Q.html

@michaeljulius7938 Год назад

Very concise

@animatedbiologywitharpan Год назад

Please share my channel link with your med school friends

@carlettagoodrich-mann1377 3 года назад

Madame Curio ‘s protocols for genomes. Curing the immune system. Matters.

@animatedbiologywitharpan 3 года назад

Please share my channel link with your friends and help me to reach big audience

@harshithamohan4074 4 года назад

Thank you.... Plz make a video on Ramachandran plot...

@animatedbiologywitharpan 4 года назад

It would be uploaded soon

@animatedbiologywitharpan 4 года назад

Stay tuned

@belgacem_mehdi 2 года назад

Can we say that these combinations are random

@animatedbiologywitharpan 2 года назад

Yes they are randomized.

@dogbeygodwin7519 Год назад

well explained but please take note that B cells mature in the bone marrow

@animatedbiologywitharpan Год назад

Please share my channel link with your friends and help me to reach big audiance

@noah-battlegroundsmobileindia 8 месяцев назад

At 10:32 total Vh gene segment mentioned is 51. Isnt that 40? 40x27x6=6480. Or what is the source of this information?

@animatedbiologywitharpan 8 месяцев назад

It was thought to be 40 but latest reference says 51 ( kuby immunology 7th ed)

@noah-battlegroundsmobileindia 8 месяцев назад

@@animatedbiologywitharpan okay. Thank you so much

@animatedbiologywitharpan 8 месяцев назад

@@noah-battlegroundsmobileindia please share my channel link with your friends and help me to reach big audiance

@pragatidubey8616 6 месяцев назад

Can you please provide notes of this topic

@animatedbiologywitharpan 6 месяцев назад

This is based on the Kuby immunology 6th ed.

@Vendzor 4 месяца назад

Arpan you are a @#$£%!*-ing legend man!!!!!!!!

@animatedbiologywitharpan 4 месяца назад

Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.

@couunderbarz 9 месяцев назад

Thanks!

@animatedbiologywitharpan 9 месяцев назад

Please checkout our entire immunology playlist. Please share my channel link with your friends

@animatedbiologywitharpan 9 месяцев назад

Immunology playlist link ru-vid.com/group/PLKtiwIJ8Q7rq77W7r4cXPrbhi_VpLWw8c&si=KogBYNwNYcG-lV8p

@michaelh8854 2 года назад

still havent explained how you can billions of different alleles.

@bivasnag6810 4 года назад

greatly explained but so u have any method to remember this terminology

@animatedbiologywitharpan 4 года назад

Bivas Nag ups I don’t have tricks for this

@cassiecatacalos1267 3 года назад

I'm giving an immunology presentation this week to a class of about 10 people. Do I have your permission to use some of your images in it? I'd give you appropriate credit :)

@animatedbiologywitharpan 3 года назад

Sure but please cite my channel link

@cassiecatacalos1267 3 года назад

@@animatedbiologywitharpan you've got it! Thank you

@1100241540 3 года назад

VDJ mechanism is poorly explained here..it does cover the background..but according to the title it should be focusing more on VDJ recombination itself

@animatedbiologywitharpan 3 года назад

Thanks for the criticism.... it's just an birds eye view....eventually I will summarize Tonegawa's work on VDJ recombination

@1100241540 3 года назад

@@animatedbiologywitharpan only great people take criticism positively. Wish you all the best and just to clarify, I do enjoy your videos