Pinning the route here for anyone who would like to learn the run: docs.google.com/spreadsheets/d/1kX4N5FU0YMUbx_CDXjdsOtu8aVJnILNrvzX4ZkS0Lf4/edit?usp=sharing Edit: Future Jon here to hijack the comment (and leeching off of the high traffic of this video, shh). This run has been done on an outdated version of the route, me and shaggy improved the route further and the WR is currently sitting at 3:50:36! Here's a link to the WR VOD which uses the updated route featuring mom- I mean Cleopatra ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-LN9ZCViwEKk.html
The addition of innate skills like pandemonic feast will be really relevant for canon of creation routes. Reduced lvl scaling will definitely play a big part as well. The canon of creation routes will look totally different from vanilla.
I imagine the TNE route won't change too much since you still need to hit level 80 to access the Shiva fight. But you will definitely have a lot of new teambuilding options.