Fatty liver disease means that you have fat deposits inside your liver. These deposits may keep your liver from doing a good job of removing toxins from your blood.
Obesity is the most common cause. Obesity in the U.S. has doubled in the last decade, and health care providers are seeing a steady rise in fatty liver disease. Although children and young adults can get fatty liver disease, it is most common in middle age.
The major functions of the liver include:
-Bile production: Bile helps the small intestine break down and absorb fats, cholesterol, and some vitamins. Bile consists of bile salts, cholesterol, bilirubin, electrolytes, and water.
-Absorbing and metabolizing bilirubin: Bilirubin is formed by the breakdown of hemoglobin. The iron released from hemoglobin is stored in the liver or bone marrow and used to make the next generation of blood cells.
-Supporting blood clots: Vitamin K is necessary for the creation of certain coagulants that help clot the blood. Bile is essential for vitamin K absorption and is created in the liver. If the liver does not produce enough bile, clotting factors cannot be produced.
-Fat metabolization: Bile breaks down fats and makes them easier to digest.
-Metabolizing carbohydrates: Carbohydrates are stored in the liver, where they are broken down into glucose and siphoned into the bloodstream to maintain normal glucose levels. They are stored as glycogen and released whenever a quick burst of energy is needed.
-Vitamin and mineral storage: The liver stores vitamins A, D, E, K, and B12. It keeps significant amounts of these vitamins stored. In some cases, several years’ worth of vitamins is held as a backup. The liver stores iron from hemoglobin in the form of ferritin, ready to make new red blood cells. The liver also stores and releases copper.
-Helps metabolize proteins: Bile helps break down proteins for digestion.
-Filters the blood: The liver filters and removes compounds from the body, including hormones, such as estrogen and aldosterone, and compounds from outside the body, including alcohol and other drugs.
-Immunological function: The liver is part of the mononuclear phagocyte system. It contains high numbers of Kupffer cells that are involved in immune activity. These cells destroy any disease-causing agents that might enter the liver through the gut.
-Production of albumin: Albumin is the most common protein in blood
serum. It transports fatty acids and steroid hormones to help maintain the correct pressure and prevent the leaking of blood vessels.
-Synthesis of angiotensinogen: This hormone raises blood pressure by narrowing the blood vessels when alerted by production of an enzyme called renin in the kidneys.
Curcumin Ameliorates Nonalcoholic Fatty Liver Disease through Inhibition of O-GlcNAcylation
Da Eun Lee et al. Nutrients. 2019.
pubmed.ncbi.nlm.nih.gov/31717...
The effects of curcumin supplementation on liver function, metabolic profile and body composition in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trials
Mohammad Jalali et al. Complement Ther Med. 2020 Jan.
pubmed.ncbi.nlm.nih.gov/31987...
Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial
Sepideh Rahmani et al. Phytother Res. 2016 Sep.
pubmed.ncbi.nlm.nih.gov/27270...
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4 июн 2024
