17alpha Estradiol, SGLT2 Inhibitors, Glycine & NAC | Dr Brad Stanfield Interview Series Ep 4

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In this video Dr Stanfield talks about three of the most promising molecules which have come out of the ITP testing. These are 17alpha-Estradiol, SGLT2 Inhibitors and Glycine & N-acetylcysteine.
Dr Brad Stanfield is a medical doctor trained and practicing in New Zealand. He has created a popular RU-vid channel where he shares the latest research around why we age and if we are any closer to finding ways that extend healthspan.
Dr Stanfield's RU-vid Channel
/ @drbradstanfield
And Twitter:
/ bradstanfieldmd
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#bradstanfield #17alphaestradiol #SGLT2inhibitors #glycine #NAC #glutathione

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6 фев 2022

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Комментарии : 66

@ModernHealthspan 2 года назад

If you would like to support our channel, we’d love a coffee ☕…thank you! www.buymeacoffee.com/mhealthspan

@DrBradStanfield 2 года назад

Thanks again for having me, lots of exciting data coming through

@rafaelortega1376 2 года назад

I think that even 1.5 grams of NAC (N-acetyl-cistein) twice per day is a lot. I felt really strange after doing that once. Not bad, only strange. I cut my finger yesterday and it bleed a lot taking 0.6 g twice per day. I know it is a blood thinner bad I did not expect that much effect after only two weeks of use.

@ModernHealthspan 2 года назад

Hi Dr Stanfield Thanks for coming on our channel and the work that you do!

@thecat8503 Год назад

@@rafaelortega1376 I have minor changes related to blood coagulation and I noticed that small bruises apper on my body if I take NAD. I don't know for sure if this was the cause, but I stopped NAD.

@byrnedegrandpre8884 2 года назад

Brad Stanfield is a remarkable young physician. His attention to quality research and his ability to integrate all the data he gathers is amazing. He's very careful about focusing on the data and its implications, hence the truth or as close to the truth as possible.

@rikishi555 Год назад

Is he young? I heard he's above 45

@byrnedegrandpre8884 2 года назад

Excellent interview Richard. You do such a good job of presenting excellent questions, then allowing your guests the chance to provide a full response. Richard, I also look forward to your self- reports about your own experience with health and life extension molecules. Thanks very much.

@ConflictedYouth Год назад

Big plus for getting Dr Stanfield

@dlg5485 Год назад

I recently started taking Glycine/NAC and I began to see significant benefits within just a few days. I'm only taking 2000mg of glycine and 1200mg of NAC daily, about 1 hour before bed. My sleep quality improved and my morning workouts also feel a bit easier and recovery shorter. I was already taking ALCAR and ALA which also seem to benefit overall well being and performance. I am trying to reduce the number of supplements I take to just the most beneficial because I don't want to overtax my liver over the long term. With so little human trial data, it's difficult to know what is giving me the most benefit without trying them out for myself and even self experimentation isn't scientific. So far, I'm pretty well convinced that these 4 molecules are quite beneficial, so I plan to continue with these for now.

@scottmiller2591 Год назад

Two of my favorite people in this space!

@Mark-sg2rg 2 года назад

Great info, good questions & answers!👍👍

@mph3339 2 года назад

Great interview. Very pertinent topic matter. Thank you both!

@ModernHealthspan 2 года назад

Hi thanks for your kind comment.

@danno1800 2 года назад

Thank you both for that helpful information.

@ModernHealthspan 2 года назад

Hi Dan, thanks!

@aa-xn5hc Год назад

Excellent interview

@cmihalcea 2 года назад

Excellent video!

@abdelilahbenahmed4350 2 года назад

Thx Richard. Interesting interview.

@ModernHealthspan 2 года назад

Hi Abdelilah, thank you!

@prubio9113 2 года назад

Always be yourself unless you can be Batman, then always be Batman.

@johnvogt621 2 года назад

Your new microphone sounds great Richard. Good on the ears.

@ModernHealthspan 2 года назад

Hi John, thanks! Great to hear that it is making a difference. Next I need to work on improving the room acoustics!

@uelude 2 года назад

@@ModernHealthspan especially above (ceiling), beside, and behind the microphone. Elsewhere you can cover acoustic foam with printed canvas for aesthetics. Make sure you have the mic set to hypercardioid, and every inch closer the better.

@Nelis1324 2 года назад

Estradiol sounds really interesting. Reminds me of a study with an estrogen like substance that promotes myelin repair of nerve fibers. It also partially restored vision.

@ModernHealthspan 2 года назад

Hi thanks for sharing. I just did a search on this, perhaps this is the report: www.nationalmssociety.org/About-the-Society/News/Estrogen-like-Compound-Repairs-Myelin-and-Partiall. Looks interesting.

@wolfvision47 Год назад

What are you saying regenerates myelin sheath?

@andrewfinlay5160 2 года назад

3 grams NAC and 3 grams of glycine.. gonna try that...seems reasonable..

@annettewilford7568 Год назад

Why

@andrewfinlay5160 Год назад

@@annettewilford7568 glutathione level ..

@roslynrogers6407 8 месяцев назад

Hi Dr Stanfield. I have been following you & love your information. Actually, I’ve been doing many of your recommendations for many years. My picture is recent & I am 82 yrs old & very healthy.

@oibal60 Год назад

Thanks for this. I take 600mg NAC a day. A great precursor to glutathione.

@ddutton4716 2 года назад

Which of the SGLT2 inhibitors is most cost effective (effectiveness per dose /cost per dose)? Another great summary.

@soultox Год назад

Empagliflozin has best results on all of the parameters they measured. Dunno about the price tho!

@zisoskatsiapis656 2 года назад

Re: 17alpha Estradiol: Which pharmaceutical company produces it? Under which brand name is it marketed?

@otherone1234 Год назад

@darkhorseman8263 2 года назад

Most people think NAC is good just for Glutathione, but slow release H2S donors regulate Sirt3. H2S is an important exogenus signalling molecule. There are much better slow release H2S donors than NAC, though. It's not unusual some chemicals like 17alpha Estradiol boosts longevity in male mice, just like women get cognitive boost plus weight/fat loss from BDNF mimetics like 7,8 dihydroxyflavone, yet men only get a cognitive boost, no weight/fat loss benefit. BDNF mimetics being superior for women.

@ModernHealthspan 2 года назад

Hi Thanks for sharing. What would you suggest as better H2S donor? Interesting about how the hormone mimetics work.

@darkhorseman8263 2 года назад

@@ModernHealthspan Most foods linked to NRF2 modulating effects have high quality H2S donors. Things like Diallyl trisulfide, or the chemicals commonly found in Brocoli or Garlic. As for me, I've been testing S-Propargyl-Cysteine and Thioglycine in rats; they seem quite efficient. Not sure if they are suitable for supplementation.

@allurbase 2 года назад

I wonder if there is any natural sourced SGLT2 Inhibitors. I guess not any diuretic makes it.

@Telecom515 8 месяцев назад

A number of RU-vid videos on Glynac said that Glynac will interact with glutamate to generate glutathione. Glutathione will then neutralize hydrogen peroxide and water is created in the process as a byproduct. My question is where does the water go? Would it be excreted as urine, or would it be used by cells?

@nevakelly7052 Год назад

Would be great to find out what is causing the diabetes and kidney disease. How are the medications clients are on is distroying kidney's

@ronm6585 2 года назад

Thank you. 👍🏻

@ModernHealthspan 2 года назад

Hey Ron! Thanks!

@peregrinodisastrado Год назад

Does anybody know where to buy a reputable glynac supplement? I'm done with the amazon stuff

@michaelprotz4875 Год назад

Brad, thanks For the video. I was planning to take serine, But recently read concerning things about its impact on colon cancer. My genome sequencing puts me in the 100th risk percentile For this kind of cancer and I already had three Adenomas. If you search the research you will find Various studies talking about serine deprivation for treating colon cancer. At the same time, it seems glycine is important in cancer metabolism but that Glycine supplementation reduces inflammation and therefore perhaps the risk that you get cancer. I currently take glycine and collagen since the evidence seems overwhelming that unless you already have cancer this is probably good for you. But in my situation I continue to be fearful of serine. I would be very interested in your views as to who can take Serine. Can I? Thanks.

@michaelprotz4875 8 месяцев назад

Hi Brad, any thoughts on this?

@Nellis202 8 месяцев назад

Can anyone commenting please help . If I am taking a quality collagen product (Great Lakes), do I still need to take an additional glycine supplement with NAC . What I mean to ask, is the glycine readily available as a single entity, or is it tied up in the collagen.

@LOFIGSD 2 года назад

Good video, the question for me on these mice trials and how they relate to general human health, is the diet and lifestyle of the mice, all very well to say a particular molecule actually shows a benefit, if the mice are kept in perfect conditions, and on an exercise regime, human data needed, both in chronically ill and healthy individuals, age also plays a huge part, which mice dont reflect. NAC sounds interesting, the US now classifying it as a Drug, which sounds like Big Pharma to muscle in, they dont want people getting healthy, without making billions out of it, thats very clear. I'm mid 50's, and certain supplements I take really make a difference, but I wait and see, before introducing new ones, glad I didnt take Resveratrol for example.

@dlg5485 Год назад

The unfortunate truth is that mice trials don't translate to humans very well at all. There is too much difference in our physiology to glean anything meaningful. This is why human trials on all of these molecules are so desperately needed. I wouldn't say mice trials are useless, but primates would be better subjects since they are much more closely related to humans.

@manuelojeda9144 2 года назад

Doctorcito Claim all the money in the World.

@orion9k Год назад

8:30 that's odd that you're saying too much anti oxidants can get in way. I've had great success from taking big doses of c vitamin, 2 grams 4 times a day (with every meal), it's made my muscles less sore and able to push harder in the gym.

@MaLaNdRaGeM123456 Год назад

Yes, but in order to the muscle grow it need to be oxidised for a while, like a stimulus

@tracymullane8818 Год назад

It's like anything else... Muscle fibers have minuscule tears, even the lactic acid attacks your tissues... Then you rest and the body repairs and builds the tissue up where you have injured it. It produces its own SOD and a whole bunch of other stuff in reaction to the ROS in the tissues and the musculoskeletal level. As long as you don't injure yourself, it's all good.

@waynebrewer8908 11 месяцев назад

doesnt it take 3 omino acids to make glutathione.

@9kilsyth Год назад

My issue with all these studies they are too short. Anything that works will most probably change things over a long period. It is like health and fitness these things only become apparent over a long time.