Why is Everyone Taking GlyNAC? 

Awesome! Thanks for sharing. I'm sure it will be helpful for others to see your comment here. Thank you.

B's. Stop seeking fake supplements after videos made by shills like this one. Your problem is excess carbohydrates and amino acids deficiency. Become carnivore and do some fasting too. That's all you need and will be really effective instead of palliative.

Congratulations. That is great news. As I read various comments I am very interested in the results people have that have improved their life.

I don't. I haven't researched that specifically. Sorry.

I have read that it tends to lower blood pressure that is why they recommend that people on high blood pressure lowering medication should not take Glynac because it may lower blood pressure too much

That's interesting and something I haven't heard yet about GlyNAC. Thank you so much for sharing. I'm glad you're seeing positive results.

I've heard around 9 gm per day, you dose may be too low and ineffective

66 and working a stressful job? Hats off to you sir 👏 👒

Im only taking glycine (just glicine) for 25 days and feel more calm to, im liking it alot

I just bought a glynac supplement that is 600mg NAC and 70mg glycine. Is that ok? Should it not be 1:1? Confused. Help! There is also 20mcg of selenium.

Wow. Glad to hear it's been helping you. That's pretty good evidence I'd say. As you mentioned it could be something else but blood tests are far better than someone saying "I feel better". I really appreciate you sharing your story here. Very interesting to read. Thanks again.

You need 3D ultrasound to conclude on NAFLD or fatty liver reversal. Your LFT, liver enzymes & lipids can be in normal range even with fatty liver.

That's awesome. Thank you so much for sharing your personal experience.

👍👍👍👍

Sir, nac is n acetyl cysteine right?

Thanks for sharing. I'll have to try using glycine as a sweetener. Thanks again.

Oooh, that's a lot of NAC per day, be careful, there are ? about long term use at high doses and toxicity!

it's not NAC she's taking glycine only @@Nandymon

@@Nandymon That is not a high dose at all. Some people take much more. Each person is different and has different needs and tolerances. Splitting an amount into different times of the day is good. More likely to be taken up and utilized. Also, remember that different sexes, different weight individuals, different exercise regimens and different diets and lifestyles all have an effect on what a given person needs and tolerates best. 👍 It is also true that a person should be mindful of how much they take so they can be consistent.

Awesome! Thank you so much for sharing your own experience. So glad it helped you.

Awesome! Thanks for sharing your own experience. I'm sure this will be helpful to others.

Awesome! Thanks for sharing Harold. Glad you're feeling great!

Yeah, a lot of people like to take glycine in the evening for that reason.

You were taking way too much. I take 600 mg/Glycine before bed same waking . That's it.

That's good to know. Thanks for sharing your own personal experience.

@@george6252 yes agree learned it the hard way. But back then I was under tremendous stress and NAC + Mucuna was helping me getting things done, its easy to get carried away.

600 mg is not even spitting n the ocean as far as dose. Everybody is different and responds differently to…..

Awesome. So taking a higher dose like they did in the study. Makes sense. Glad it's going well for you. Thanks for sharing.

You should spend some time on pub med. More is not always better with antioxidants, taking too much NAC can go the complete opposite direction. You should be careful. Peer reviewed studies show that excessive dosing with NAC/ in combination with other antioxidants can produce oxidative stress. The person hosting this channel is derelict and ignorant to chime in with you that this is a good idea. Do your homework. I have one and a half kilos of NAC in my refrigerator, I am clearly an avid fan… I take 800 mg with 2 g of glycine twice a day. I also take 2 g of taurine, NMN, and other things too numerous to list here, YOU HAVE TO DO A LOT OF RESEARCH TO FIGURE THE BALANCE THAT WORKS HERE. Your system, your organs still have to process these things. They can be good for helping the kidneys, eliminate toxins, but too much is literally burdensome on the kidneys, and does the exact opposite. SPEND FIVE MINUTES ON AN AI APP AND SIMPLY ASK, “CAN I TAKE TOO MUCH NAC OR OTHER ANTIOXIDANTS? WHAT ARE THE GUIDELINES?” AND YOU’LL BE SET.

@@JTJaredTaylor no, it is not awesome at all, it is ignorant and according to peer-reviewed research, this can be toxic, cause serious oxidative stress,. And you should be doing your duediligence and correcting this person.

Regarding the extremely high dosage of 8 grams (8,000 mg) of N-Acetylcysteine (NAC) per day, as recommended by the RU-vid channel host, this is a concerning and potentially dangerous level that is not supported by peer-reviewed research. According to the available scientific evidence: 1. Recommended Dosage of NAC: - The typical recommended daily dosage range for NAC supplements is 600-1,800 mg, divided into 2-3 doses. (1) - Dosages above 2,000 mg per day are generally not advised without medical supervision. (1) 2. Potential Risks of Excessive NAC: - Very high doses of NAC, such as 4,000 mg or more per day, have been associated with adverse effects such as nausea, vomiting, diarrhea, and abdominal pain. (2) - Excessively high doses of NAC can potentially lead to an imbalance in the body's oxidative state, potentially causing more harm than good. (3) - The antioxidant properties of NAC can become pro-oxidant at extremely high doses, leading to increased oxidative stress and inflammation. (3) 3. Importance of Maintaining Oxidative Balance: - Moderate levels of oxidative stress are essential for the body's natural defense mechanisms and cellular signaling processes. (4) - However, excessive oxidative stress can damage cells, proteins, and DNA, leading to various health problems. (4) - The "line" between beneficial and harmful effects of antioxidants like NAC is not absolute and can vary based on individual factors, dosage, and duration of use. (3) In summary, the recommendation of 8 grams (8,000 mg) of NAC per day is significantly higher than the established guidelines and poses a serious risk of causing more harm than good due to the potential for disrupting the body's delicate oxidative balance. This dosage is not supported by peer-reviewed research and should be strongly discouraged. Consulting a healthcare professional is advisable before starting any high-dose supplement regimen. References: (1) Mokhtari, V., Afsharian, P., Shahhoseini, M., Kalantar, S. M., & Moini, A. (2017). A review on various uses of N-acetyl cysteine. Cell journal, 19(1), 11. (2) Aldini, G., Altomare, A., Baron, G., Vistoli, G., Carini, M., Borsani, L., & Sergio, F. (2018). N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radical Research, 52(7), 751-762. (3) Bouayed, J., & Bohn, T. (2010). Exogenous antioxidants-Double-edged swords in cellular redox state: health beneficial effects at physiologic doses versus deleterious effects at high doses. Oxidative medicine and cellular longevity, 3(4), 228-237. (4) Sies, H. (2015). Oxidative stress: a concept in redox biology and medicine. Redox biology, 4, 180-183.

Awesome! Thanks for sharing your own personal experience Susan! I'm sure this will be helpful to others.

How many mg/g of each do you take? Thanks

It is IN FACT a rate limiting factor

How could it not be additive since both are needed to produce glutathione?

Yes. I believe it does from what I have seen, read and experienced. Also, remember that people don’t always digest things as efficiently as they get older. And many people don’t take in as much protein as they should. And glutathione is not as plentiful to do it’s job in the body as we get older. Glutathione is a tripeptide made up of NAC, Glycine and Glutamic acid. Having the building blocks available helps guarantee that the body can make all the glutathione it needs for repairs, etc. Add in Creatine, taurine and a few other amino acids and nutrients and you will find the energy level and mental focus definitely improves. You might add Co q 10 also. It’s absolutely necessary for the mitochondria in the cells.

I believe wolfing down works! The studies I've seen they gave participants both Glycine and NAC but as separate supplements NOT chemically bound. Many people choose to buy them in bulk separately and then just take them together at what ever time the choose during the day.

Hi, Thanks for sharing. I haven't noticed that myself. Maybe someone else will comment. If I understand correctly Ashwagandha is also supposed to help regulate blood pressure.

Lions Mane and Niacin :)

NMN

Taurine has some pretty strong research. It would be hard to list all of the things that are good to take. I can share my current "longevity stack" if that helps. I am currently taking NMN, Creatine, TMG, GlyNAC, Collagen, Whey Protein, hyaluronic acid, saw palmetto (my hair is falling out), vitamin D, vitamin K2, magnesium. I also try to get at least 2 tablespoons of olive oil each day as well as 1 tablespoon of psyllium husk. I've also been taking omega-3's but have put that on pause for a little bit because I'm getting ready to start an experiment to see how much I can raise my omega-3 index. But normally I try to take omega-3's every day as well. I also need to mention that taking a bunch of supplements without following a healthy diet isn't going to help much. Regular exercise is also hugely important as well as good sleep. Hope that helps.

@@JTJaredTaylorsurprised you don’t take resvertrol with the NMN.

@@JTJaredTaylor What in N & TMG?

Interesting. I've heard that NAC is actually helpful for treating respiratory issues. I wonder if the phlegm in your throat was due to a mild respiratory irritation. Just thinking out loud. Thanks for sharing your own personal experience. I'm sure it will be helpful to others.

@@JTJaredTaylor I had the mucus drip for years now gone.

I have this right now my entire life

Love it. Thanks for sharing. Glad it's helping!

Why take methionine?

Thanks for sharing your own experience. I really like what you're doing. Very healthy habits for sure. I love that you're seeing cognitive benefits. I have to say the thought of that kind of decline haunts me once in a while. I'd like to avoid it if at all possible. Thanks again.

Excellent plan. You kept the best and most useful.

I want to try it for the same reason. Actually I bought it few months ago after having C19 and it helped a lot with my lungs. Also I wanted to recover from the weakness I felt. I was also previously diagnosed with chronic fatigue syndrome.

Great question. You'd have to check for different options and choose one you're most comfortable with. I see that Labcorp offers a test that measures levels of Glutathione also called GSH. Ideally you would do the test then take GlyNAC for a period of time and follow that up with another test. This could tell you if it's been effective and if you need to increase the dose etc. Hope that helps.

You're very welcome. Thanks for watching. In the studies that I've seen and particularly the one that showed so many benefits they used a 1 to 1 ratio. That seems to be the most common recommendation.

Awesome! Thanks for sharing your own personal experience.

How are u feeling after adding in Glycine? Ty

Still waiting for delivery!

Hey Dan, Is it possible that the reaction was caused by something else? If not that sounds like an allergic reaction. The research says NOT to keep taking it if you have such a reaction. I don't think I'd want to risk that. At the very least consult with a doctor. I personally haven't had that issue and I recently took straight NAC at a pretty high does. 6000mg several days in a row. I was taking it in an effort to prevent getting sick. I ended up with mild side effects but it gives you an idea about a range of tolerance. Here's a video about that. ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-hF3mQFCSc-8.html Hopefully others can help shed more light on this for you as well.

It really is, isn't it?

You're very welcome. I'm glad you liked the video. Thanks for watching and thanks for letting me know. I really appreciate it.

Hi thanks for watching and thanks for sharing your own experience here. My approach would be to take it on an empty stomach and if I feel any gut issues try taking it with food. Hope that helps.

Yes you can. Many people chose to do that. And it's more affordable. Just make sure it's third party tested for quality and purity and manufactured to GMP standards and you should be fine.

I'm looking forward to Blueprint.

Awesome!

Sorry to hear it. I can't say I experienced that but thanks for sharing your experience. I'm interested in hearing what other people say. Thanks again.

@@JTJaredTaylor Thanks…wish it wasn’t this way, however perhaps trying at a different dose will result in a different or no unwanted side effect. Will post if I notice a difference. Cheers!

Can I take them together?

You make less money though promoting expensive brands of pills...

I had fun putting those in! I'm so glad someone appreciates it! My daughter is actually watching old spongebob episodes right now. 😊

Awesome! Thanks for sharing.

That's awesome to hear. I'm glad you've been able to find things that have been so helpful. It's a great feeling to be able to say, "I have felt better and better." Thank you for sharing your own personal experience.

Great! How's it going for you?

My understanding is that it's perfectly fine to take it when you're younger but it's just that you will notice improvements more the older you are since glutathione levels decline as you age. Hope that helps.

Thanks for watching and thanks for sharing your thoughts. Great question. The reason people (including myself) say "As we age..." is because that is the most straightforward and accurate way to say it. Think of it this way. There is a reason professional athletes (in most sports) are considered too old by the time they reach their mid-thirties. It's not that toxins from food air and water have accumulated in their body, it's that as we get older things in our body change. Yes, we are still being exposed to toxins but healthy kidneys and a healthy liver will be removing most toxins and waste from your body. Our bodies change as we get older. For example your fast twitch muscle fibers start to atrophy at a faster rate especially after we reach our late 20's. These muscle fibers are responsible for explosive movement, power and speed. Hormone levels change. Testosterone levels decline in men and estrogen levels decline in women. This is one reason TRT or hormone replacement therapy has become so poplar. Bone density changes (becomes less dense). Your Vo2Max (cardio fitness) declines. Your body's ability to process protein and turn it in to muscle declines. You can still do it, but your body becomes less efficient at it. It becomes harder and harder to build muscle and strength. Stomach acid declines so foods are not digested as easily. Collagen levels start to decrease around your mid 20's and continue to decline every year, which is why we start to see wrinkles sometime in our 30's. Cells become older and stop dividing. NAD levels decline and as mentioned in the video Glutathione levels naturally begin to go down. The list goes on and on. We have to work at restoring or preventing or preserving these things much harder as we age, whereas when we're younger, we don't have to worry about it because all of these things are either improving or maintaining. That all changes later in life and it happens for the most part a little at a time over time. This is why people say "as we age.. this begins to happen etc" because that is really what's happening. I sure hope that helps answer your question. Thanks again.

It shouldn't but of course it's best to check with your doctor.

@@JTJaredTaylor Yes , your right . But one could get the idea that the doctor maybe don't know , and therefore to better be save , would say I wouldn't recommend it ! 🙃 Which is cool , but doesn't help a lot . This field is so new that I guess its almost impossible even for doctors to keep up . I have taken NAC earlier because of a RU-vid video that suggested it could reverse grey hair 😀 , actually I think it worked a little ! My question was because I thought about giving my old mother (83) it , but she takes pills for high blood pressure !

Nope. They mention that topic in the study. Once people stopped taking GlyNAC unfortunately the benefits diminished. 6:03 in the video references that topic. Hope that helps.

Great question. I haven't researched GlyNACET yet so I'm not the best person to answer that question. Something simple (plain ole NAC) can still be helpful. I made the video about NAC because I was wanting to learn more about it, in and of itself. I just happened to be doing some research on it when I started feeling sick. I thought it would be a good time to try it out for myself and why not make a video about it while I'm in the process. I'll have to check out GlyNACET. Thank you.

My understanding is that a 1 to 1 ratio is generally recommended. So with 600mg NAC I'd also do 600mg glycine. Hope that helps!

A lot of people do just that. It is more affordable to order then separately.

Good point. The bottle for your tablets or capsules should say how many grams of GlyNAC you're getting in each one.

Bromelain + NAC

Of course you can but do you need to? The studies suggest that glutathione levels begin to decline in our mid-40's. We're all different so giving an exact age is impossible but you likely have some time yet. Taking GlyNAC at your age will be safe but you'll likely not experience the same benefits as someone in their 40's 50's 60's and beyond. Hope that helps.

Hi Martin, Sorry. I'm not quite sure what you're asking.

@JTJaredTaylor the talk was about Glynac. The first part of the word was a shorthand of the word glycine, i was asking what the second part nac was....? I have since looked this up

@@martinbennett9578 I see. Thanks. Were you able to find the information you needed?

@JTJaredTaylor yes but there are a lot of people talking about it. It is a lot of reading. Could you recommend a recent source on the subject as it is of interest? I've begun taking a glycine supplement (a company called Nutra 1300mg per serving) and a hydrolyzed multi collagen supplement (company called codeage) 2000mg per serving. I'm taking this daily as from 25.03.24. Any pointers in the right direction would be appreciated.

GlyNAC is digested and absorbed by your body allowing your body to build glutathione and regulate how much goes to which cells and when. Liposomal Glutathione passes right by your bodies ability to regulate it and goes straight to the cells. The issue is you run the risk of jamming your cells with too much at the wrong times which can cause reductive stress and may actually accelerate aging rather than slow it down. Hope that helps.

Great question. There is research that indicates NAC may actually lower blood pressure. Here's one example. www.ncbi.nlm.nih.gov/pmc/articles/PMC2721729/ That said, if you're taking medication you would want to be sure there are not any drug interactions. I'm certainly not qualified to give you the best answer there. I'd highly recommend you check with your doctor or pharmacist. Sorry I can't give you a more clear answer on this.

No. Glycine is an amino acid. A building block for proteins. Where people might get confused is when going on a calorie restricted diet studies have shown that the addition of glycine helps prevent muscle loss. If someone hears "fat loss" and "glycine" together they may think it means glycine helps you lose fat by lowering the impact of carbohydrates. But it's the lowering of calories and or carbohydrates that does it. Not the glycine. I hope I'm answering your question. I hope it helps.

Yes. I have and do. Keep in mind they are for different things. NMN for increasing NAD+ and GlyNAC for elevated Glutathione levels.

No, just pure glycine. TMG or betaine is a form of glycine that has 3 methyl groups. It's a little different.

Sorry to hear that. I haven't experienced that personally and need to do more research. Hopefully someone else can help. Thanks

It would appear to be too powerful for you right now. Maybe have a break and retry with smaller dose of Glycine by itself first , and then NAC on own to see which one is not right for you , right now .

I took glycine in the day time once and experienced similarly.. so tired and fatigued all day .. now I take nac 600 mg in the morning and glycine 3gms at bedtime and sleep like a baby !

It makes me feel good when i consume it, but Ive wondered if it gives me a hangover. I only do a small dose of like 600mg of each.

Sadly it's prob more dangerous to listen to doctors on the many many many so called medications they try to shovel into each person..

Do you sleep with an old or down pillow or comforter? I got rid of mine and it went away pretty quickly. Could be dairy. I only use raw. Could be animals or other allergies. Look in to quercetin?

Oh. Also could be glysophate , it’s in all American wheat products.

Awesome stuff here. Thanks for sharing. I love grapefruit and I may just have to try that.

@@JTJaredTaylor just be mindful what else you take with the grapefruit as it can greatly enhance takeup 😉

I use magnesium glycinate with nac

100mcg per 1kg of body weight+1 NAC+1 PQQ per day for ever...

@@zoranpaunovic6701 What’s PQQ?

Spelling???😂

@@piperuk5366 Yep, it's a banned substance at spelling bee championships

Because people in their 70s will get the most benefit from Glynac

relax, Im 69

From what I read 600mg a day is good for daily maintenance.

Yeah it does get expensive right? It's frustrating. I have a lot more to learn but the studies that show significant benefits were using pretty high doses. It seems a little prohibitive for most people. That said, my feeling is that "some" is better than nothing. Some benefit is better than no benefit. We all need to do the best we can with what we have to work with. If 600 mg is what you can do then that's what you can do. In my view it's still better than 0 mg. Honestly I wouldn't be too concerned about it. The more I study and the more I learn about health and longevity in general, the more I believe that the fact that you're "quite active" will help you more than any supplement. Just do the best you can. That may not be the answer you're looking for but I hope it helps.

@@JTJaredTaylor try it and find out I guess. I was taking NAD for a while but it made me feel tired so I stopped.

@@mhaas281 interesting. You're not the only one I've heard that from. We each have our own unique puzzle to solve don't we?

I switch to powder form for both plus taurine. Way cheaper.

Perhaps. I would imagine there is research that attempts to answer the cancer question. I haven't heard huge concerns along those lines but it would be really good to see the research.

Related in what way ? Cause or cure ?

The study which I have read, indicates that in mice when given Glynac at a later age, because it stops senescent cells in the lungs which is good but also senescent cells have on advantage. Because senescent cell are the cells way of stopping mutating cells becoming cancerous they turn them into senescy cells that no longer divide. Problem is when Glutathione the end product of Glynac is increased in older mice it stops senescent cells being senescent and they become cancerous, this occurred only in the lungs in one tenth of the mice with a certain gene. Humans share many of illnesses with mice that is why it has attracted attention. The paradox about this is that too many senescent cells because they are inflammatory often do cause cancers in people, as well as heart disease, dementia and many other illnesses

That's a great question. What was the actual quality of the GlyNAC they used and what do we have available to us? Not sure if they outline that in the study or not. Probably need to take a closer look. It's linked in the description. The one I get is pure GlyNAC (Glycine + NAC). I wouldn't be interested in other options. The good thing is regular consumers like you and I, have more access to that kind of quality than ever before. Which is pretty cool.

I'm sure it's a combination of all those things. Like a puzzle made up of many small pieces that all fit together. Thanks for sharing. Glad to hear you're feeling better!

Yep.

Good idea. Thanks. I'll have to look into that.

Don't take my word for it. There are plenty of studies that anyone can find and review themselves. I've linked to one in the description of this video.

Meanwhile, you’re missing out on the benefits of glynac ☺️.

Lots of medical information on Glycerine and N Acetal Cysteine. Says Harvard for example. They are amino acids found in meat.

@@darrenvail8726 tks. I don't eat meat , I supplement HEAVY with NAC, GLYCINE, NAD . etc .

wtf are you talking about

Not yet. That's a new one. Is that a good thing?

go troll somewhere else

@@jackbouchez9573 I wasn’t trolling, I seriously wondered if it was the same person🤷🏻‍♀️

Ya he has a Winnie the Pooh type voice for sure. Easy to listen to.

What? Tons of people take these. However, most just buy them separately because it's much less expensive than combined ones like DoNotAge.

@dlg5485 it's the first time I heard about it.

@@aeiou8287 Several research studies looking at these 2 compounds were released earlier this year and they showed tremendous benefits in lab rats and in humans, so there is a renewed interest in them right now, but they've been around for ages.

this was in response to a comment posted by somebody else, which you agreed with and said "awesome" when they said they were taking 8 g of NAC a day. You are either ignorant or reckless to condone such a thing, if you were a doctor you should have your license revoked for putting that in writing.