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Berberine: Liver and Metabolic Health

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Berberine: Liver and Metabolic Health
Talk #1 on Berberine: ru-vid.com...
Berberine is a magical molecule with a vast array of effects. Today we will focus on the mechanism of the impact of BBR on liver and glucose levels.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Sunday, Feb. 10 2023
Berberine is an insulin secretagogue targeting the KCNH6 potassium channel | Nature Communications
www.nature.com...
AMP-activated protein kinase - Wikipedia
en.wikipedia.o...
Frontiers | Cerebral Gluconeogenesis and Diseases
www.frontiersi...
Phosphoenolpyruvate carboxykinase - Wikipedia
en.wikipedia.o...
Gluconeogenesis - Wikipedia
en.wikipedia.o...
Metformin - Wikipedia
en.wikipedia.o...
Sterol regulatory element-binding protein 1 - Wikipedia
en.wikipedia.o...
The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling - PMC
www.ncbi.nlm.n...
mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis | PNAS
www.pnas.org/d...
Insulin Signaling Pathway | Antibodies.com
www.antibodies...
Regulation of SREBP by insulin signaling pathway | Download Scientific Diagram
www.researchga...
The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet - PMC
www.ncbi.nlm.n...
Frontiers | Glucose-lowering effect of berberine on type 2 diabetes: A systematic review and meta-analysis
www.frontiersi...
ATP-sensitive K+ channels in pancreatic beta-cells. Spare-channel hypothesis - PubMed
pubmed.ncbi.nl...

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22 авг 2024

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Комментарии : 137

@onlyhis5870 Год назад

You’re constant admonition to ‘consult your doctor’ doesn’t hold the same weight as it did prior to CVD. Now we’re wide awake to what we’re dealing with, and that the vast majority of ‘doctors’ are essentially paid hitmen! Thank you for sharing and explaining this to us. It is greatly appreciated!

@wendycarter5718 Год назад

legalised drug pushers !!

@2bbossfree Год назад

Just keeping his channel on you tube and keeping from getting sued. He has to say consult your doctor--if you can find one that knows what he/she is doing.

@uncommonsense5876 Год назад

As a 50-something with near type 2 diabetes, Berberine has made miraculous impact in just 4 weeks of taking daily. This little natural molecule is God send 🙏😊❤

@BasedTexans Год назад

I have been taking Berberine for 6 months and it has been a miracle for me. I am taking it for weightloss. The weight has literally been melting off after taking this. It helps me by working as an appetite suppressant, this helps me maintain a caloric deficit. It also gives me energy. I take 1000 MG. I started with 500 MG and it did not work as well. I have not had any side effects. I absolutely love this vitamin. I suggest mixing it with a keto or low carb zero sugar diet. That is if you seek to use this for weight loss.

@mjgrant1515 Год назад

i was taking 500 mg a day for a few years but my naturopath suggested i up it to 1000 mg a day. she said the studies were done with 1500 mg. i take it for blood sugar control & it works for that but i also lost a few pounds with bumping it up. it seems to work better for me if i take it 1/2 hour before meals.

@deebrown7160 Год назад

Its not a vitamin. Its a plant

@destinationunknown4959 Год назад

What brand do you take?

@mariecallahan9975 10 месяцев назад

What brand do you take?

@lilolmecj 9 месяцев назад

@@mariecallahan9975I take Thorne, because I trust them to produce high quality products. But I think any reliable brand would do.

@cybernurse2020 Год назад

I've been taking Berberine for several years (for all properties Dr. Been discussed). It's also popular among the "anti-aging biohackers", along with Metformin and Rapamycin.

@johnparra8388 Год назад

I put my wife on it about a year ago. We had to buy a Powder Scale in order to take the correct dosage. My Wife and I are taking Bitter Melon to control blood sugar.

@johnparra8388 Год назад

Milk Thistle works great along side Berberine.

@nicolasvanlangendonck9179 7 месяцев назад

Did you find scientific foundation explaining effect of Berberine as "anti-aging" agent

@johnsnider2006 Год назад

Most physicians would not know what berberine does let alone the drug interactions... Basically you are on your own in the US if you are taking it.

@SupremeODMG Год назад

Many things they don't know. nac or natto they never heard of till I brought it up. Made them Google it lol.

@maplenook Год назад

Might be better off doing own research

@techadsr Год назад

@@SupremeODMG interestingly, my daughter in Australia had NAC recommended to her by her doctor during and after her 3rd bout with Covid. Could it be that some doctors are listening?

@BasedTexans Год назад

This is true I asked my doctor he had no clue

@SupremeODMG Год назад

@@techadsr very few.

@areugnat5484 Год назад

I’ve been taking berberine for about 6 months and was very happy to learn the details of the mechanism of action. Thank you!

@republiccooper Год назад

Did you take it for a particular health issue or for general health maintenance?

@areugnat5484 Год назад

@@republiccooper, my HgbA1c was 5.6 and to improve digestion.

@republiccooper Год назад

@@areugnat5484 What has your experience been?, if you feel comfortable to share.

@areugnat5484 Год назад

@@republiccooper Positive. No adverse reactions. The HgbA1c dropped 2 points.

@republiccooper Год назад

@@areugnat5484 great!

@billytheweasel Год назад

Thanks for getting back to this Dr Sayed. I read all I could find years ago and am very interested in a deeper understanding.

@9111logic Год назад

🇬🇧🙏This is simply magnificent! How many pathways and mechanisms ! Love it ! Thank you Dr. Mobeen 🥰🙏🙏🙏

@lindag9975 2 месяца назад

Thanks! I have been taking berberine for a year. Along with major changes to my diet, taking berberine has helped me lose weight and lowered my A1C from 5.3 to 5.2. A few months ago, I switched to dihydraberberine.

@terfalicious Год назад

Wonderful presentation. Love your art, clear explanations, and topic. Blessings on your head, Dr B!

@jenniferfrance1736 Год назад

I have been taking berberine for years. It works for very nicely for me.

@dfms3485 Год назад

This supplements elevate your liver enzymes?

@user-tm1ec2on6w Год назад

Thank you for all this wonderful information.

@Feinrizulwur Год назад

Absolute wonderful. Thanks a lot.

@pattyorourke8068 Год назад

Thank you so much for the information on berberine! I really appreciate these talks. 😊

@sabrinalb2386 Год назад

Very informative thank you doc

@DrBeenMedicalLectures Год назад

My pleasure

@SupremeODMG Год назад

I did see a study also mentioning a bit of help with ApoB which I thought was odd, I have high Apob but I eat high fat low carb and my ldl is high though my trigs and stuff are all low. It's nice to see berberine helps lower apob,raise hdl lower ldl and trigcylerides as well.

@lindadowning194 Год назад

I recently started taking Berberine to help manage Blastocystis hominis, a parasite. Great to hear that it happens to work in other areas as well. Thanks for such a clear presentation of the mechanism of action. Still searching for how it works on blasto.

@jankadlcek608 Год назад

So, it technically disrupts energy pathways on multiple levels, which forces the cells to change their behavior. Compared to fasting it works whether the liver tries to compensate or not. On the other hand, it speeds up processes but does not let them get finished, which probably means a lot of unused metabolites just floating around (=a massive workload for kidneys). I would label it as a good shock therapy if your metabolism is in disarray, but a weird thing to consume daily if your body is in a good condition.

@InHisName999 Год назад

I've always been told to take it in monthly cycles. Not personally knowing the reasoning. Just advice from someone I trust on key health topics.

@monnoo8221 9 месяцев назад

@@InHisName999 that applies o everything, even types of food.

@BCSTS Год назад

Thanks forever for delving so deeply into berberine....also looking forward to the side effects video....want to take it...but have some concerns re past experience

@TheSevimuzun 11 месяцев назад

Wow! Thank you so much! May you be blessed!

@PaulHigginbothamSr 10 месяцев назад

Basically what is desired from Berberine is increased energy. Since my metabolism seems OK at this point I will take akg so it is easier to stand after sitting and lower frailty.

@alysononoahu8702 28 дней назад

Just amazing 🎉🎉🎉🎉

@randyclary8635 Год назад

Wonderful!!! Thank you Dr. Been. Looking forward to hearing more of berberine's many benefits.

@kayemoore Год назад

INVALUABLE - I’m soooo THANKFUL to you!!

@galespressos Год назад

🤔Comment, much appreciate that this talk explains mechanisms behind berberine’s effects. Glad to see an explanation. Miraculous! I had wondered about berberine because of coincidental personal experience with some supplement. I’d noticed that I felt much better, much healthier, more energy, even clearer thinking, when taking certain supplements that happened to include berberine along with other ingredients. Additionally, I lost unhealthy weight and got less sick. I hadn’t been interested in berberine but as I noticed that the supplement which included it had me feeling better whereas the ones that didn’t weren’t having such an effect, including looking better since others commented when I had taken it for a while, I thought that ingredient might be important. Although not certain, I have no way to definitively verify that was the factor, berberine seemed to be the key. Later, that supplement was no longer sold. It seemed quite effective. Even if it was a placebo (doubtful as I hadn’t noted that it was included when I started noticing the effect, and hadn’t noted originally that it wasn’t included in the other supplements), I miss the supplement. It’s too bad. The mechanism is interesting.

@TheSevimuzun 11 месяцев назад

Just take plain Berberin.

@Optimization_Coach Год назад

Excellent lecture. Thank you

@amywjn Год назад

Thanks for being so scientific & detailed.

@alexandrecouture2462 Год назад

Thank you!

@DrBeenMedicalLectures Год назад

You're welcome!

@alysononoahu8702 28 дней назад

Blessings ❤

@nancyFLRN Год назад

Great show! Thank you.

@BCSTS Год назад

It would be nice if doctors even knew what berberine is!

@saralakushwaha1180 Год назад

Thank You 👍👍👍

@t.hunter4660 Год назад

@Di Dz I am so sorry for your loss. Hope to see you back here soon.

@brendacarter2022 7 месяцев назад

Thank You for the breakdown...

@ajluckow4474 Год назад

Thes ternative solutions are fine and should be required for physicians. Although big pharma can’t patient.

@dansfontes Год назад

Congratulations from a colleague from Portugal!

@bigbranch1 Год назад

Thanks!

@susiefloosie8885 10 месяцев назад

Husband has cirrhosis of the liver and I am hoping this supplement will help him. After being on Lactulose for hepatic encephalopathy, his A1C went up quite a bit. Of course, doctors all say supplements do nothing. Enjoy your videos. thank you

@boomerang0101 6 месяцев назад

Take TUDCA not this

@carlsonterrence День назад

Don't need to "discuss it with my doctor". I have already had the "high priced urine" lecture quite enough, thank you.

@nicolasvanlangendonck9179 7 месяцев назад

Wonderfull lecture.... Thank you so much

@hiris1903 Год назад

Regarding the decrease in mRNA production and protein synthesis, are there any concerns of other (needed) proteins and enzymes being hindered? Very good presentation!

@johnparra8388 Год назад

I found out that I had to buy a Powder Scale in order to take the correct dosage of Berberine. Bitter Melon helps a lot with blood sugar.

@ryan6391 5 месяцев назад

Hi Doc, so my question is Berberine good for a fatty liver when also including this study? In science direct..".The short-term effects of berberine in the liver: Narrow margins between benefits and toxicity"......this is a 2022 study.....notes "However, safety concerns also arise because all effects occur at similar concentrations and there is a narrow margin between the expected benefits and toxicity. Even mild inhibition of gluconeogenesis is accompanied by diminutions in oxygen uptake and ammonia detoxification and increases in the NADH/NAD+ ratio. " Thanks for your opinion as this stuff can be very complicated.

@samquintanilla8836 Год назад

Pharmacology question. Is there evidence of prescription Sodium-glucose inhibitors conflicting with Beberine that unregulates these channels. Thanks, long time follower. Keep up the great work. Sam Q.

@pauldickinson5316 Год назад

Q. How does the cell use up all this excess glucose now coming into the cell as it cannot be converted to fatty acids or does it only take what it needs through glut4?

@c.k.1958 5 месяцев назад

thank you

@johnpennington9770 7 месяцев назад

It's Awesome sir 🙏

@JFK1611 Год назад

I had a strange side effect, my neck started hurting - my shoulders, like a mast cell response. I have also developed reactive hypoglycemia. I dont know if the hypoglycemia is connected, but I definately had a reaction.

@alenray75 11 месяцев назад

Thank you..

@sugzerep2993 10 месяцев назад

If ATP production is decreased in the mitochondria, wouldn't that result in decrease energy levels?

@DIABETESHEALTHS 8 месяцев назад

I took 1200mg today. I want to see whether it causes Hypoglycemia.

@VikingsFan-iu5kq Год назад

is Berberine good or bad for you liver ?

@bobthrasher8226 Год назад

Have you checked into high dose Thiamine therapy for long covid?

@bobthrasher8226 Год назад

Dr Marik's HAT sepsis protocol uses Thiamine - is it possible we have not fully exploited B1's benefits? See EONutrition - great explanation of mechanisms. A person may have NORMAL B1 levels and still benefit from high-dose B1 therapy.

@realmiamiunderground Год назад

No doctor on the planet will ever discuss Berberine with you.

@47retta Год назад

You have to go to a functional medicine doctor or a naturopath.

@elanamccullum1677 Год назад

NATUROPATHS DO💯

@techadsr Год назад

@@47retta Seems like some allopathic docs are coming around to food and supplements, mostly vitamins but at least mine aren't throwing a fit when they see my supplement list.

@mjgrant1515 Год назад

@@47retta i had 2 different naturopaths recommend berberine to me. when i told my GP i was taking it, she had to look it up on the net.

@j-uk2189 3 месяца назад

Im a pathologist and take this supplement.

@Blueskies1180 8 месяцев назад

Can bernerine be used for people who are NOT diabetic or pre-diabetic? I’m not on any medications. Thank God. I just want to know if it’s also good for normal healthy people?

@gerardbiddle1808 Год назад

Thank you once again for your great gifts to humanity, Dr King Been. You are a star shining light on mechanisms obscure to many of your peers. What a thinker/inspiration you are as you challenge further medical knowledge and research hypotheses and developments for humanity’s wellbeing. 29:04. This would be interesting to test using Dr VAShiva cytosolve system simulations. 31:55

@hunterfamilyacupuncture Год назад

Don't bother with doctors , go naturopath or a herbalist to info on berberine.

@j-uk2189 3 месяца назад

I wonder if decreases Mtor due to activating ampk will lower muscle growth

@MoodMindMemory Год назад

curious as to why you did not mentioned the impact of berberine on the microbiome and ultimately its ability to reduce post prandial endotoxemia that drives the type 2 diabetes . As you most likely aware the both Chinese medicine and Ayurvedic medicine has been using berberine for GI issues and ultimately solving the root cause of the metabolic issues that stem from the dysbiosis and post prandial endotoxemia...the mechanisms you describe can all be improved via reduction of endotoxemia...Thoughts?

@nicolasvanlangendonck9179 7 месяцев назад

Thank you. According to your explanation, therocally, it is good to take berberine before meal in order to diminish quickly blood sugar level but also during fasting period in order to avoid neoglucogenesis to happen?

@georgemather9082 Год назад

Excuse me Doctor, but are you going to present the in-vitro study on Nattokinese? They found that it destroyed the Spike protein.

@joanneclark8256 Год назад

Can you add link

@Mind69420 Месяц назад

Who's they? I want to look it up

@superlamb6395 10 месяцев назад

Thank you for the excellent explanation. What are your thoughts about taking berberine while on HRT?

@theresathurston3138 10 месяцев назад

What is the natural remedy to shrink fibroidsin the uterus

@lorypeterson7856 Год назад

What about TD1, insulin dependence & resistance?

@a_m_m-b-h-g Год назад

Is there effect from berberine to liver hemangioma?

@juliesnow3480 10 месяцев назад

Is there a brand you recommend?

@lauracarrillo884 7 месяцев назад

Can I take berberine if Im takin isotretinoin?

@Nostradamus_Order33 Год назад

First here

@DrBeenMedicalLectures Год назад

Welcome

@emailsender7139 7 месяцев назад

I have collagenous colitis. I'm wondering if the Berberine is helping with it. Sure seems to be better since I started 500mg

@emailsender7139 7 месяцев назад

Also called microscopic colitis.

@sheilahendrix5935 Год назад

Peace💜 and❤️ Blessings 💚Too💚 My 💜Brother ❤️May 💚God 💙Bless 💜You ❤️Always💚 May💚 God💜 Bless❤️ You 💚Richly💚 with Everything ❤️You💚 need 💙Always💙 Much ❤️Love💚 Blessings💙 Always ☺️ 🎇 🌈 🌐 ✌️💯💙💚❤️❤️💜💜💜❤️💚💚💙💙💙💙

@Esta4aKing 4 месяца назад

Can people who are in antidepressants take Berberine?

@alphaomega1351 3 месяца назад

Sure... if you want to unalive yourself. 😳

@47retta Год назад

So how much should we take?

@terfalicious Год назад

10mg/kg divided into 2 or 3 doses per day (from studies on berberine) - generally about 250 mg three times a day for someone 160lbs, take with meals..

@47retta Год назад

@@terfalicious thank you!

@joanneclark8256 Год назад

Inositol same

@johnpennington9770 7 месяцев назад

Not just beautiful doctor 🎉

@nicolasvanlangendonck9179 7 месяцев назад

Merci !

@floydald 17 дней назад

Beberine doesn’t do a damm thing for me

@lunar5674 Год назад

My ALT level before Covid was 12, year after Covid it's 37. GP hasn't reacted to that change and I'm freaking out what causes that spike - cancer ? which I know post covid people develop.

@2bbossfree Год назад

Watch or read Dr..Fung The Cancer Code.