Biochemistry | Enzyme Inhibition 

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Thanks to you I passed biochemistry, really great work, keep doing it because you help a lot, thanks to you from the heart...!!!

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I just memorized the effects of inhibition for 4 years during pre-med without understanding no matter how much I tried reading about it. Now I am so happy to find your channel to understand the materials intuitively in med school LOL. DEFINITELY is gonna help me retain all of this long term now. I was hesitant at first seeing the first MM equation video's derivations but it makes perfect sense why you went through the trouble to explaining the whole thing. THANK YOU!

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Thank you for doing a thorough explanation. I appreciate that you included examples.

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Slight correction: for a competitive inhibitor higher km = decreased affinity for substrate

Thanks for your efforts and all whom helping you to make these lecture clear and easy 🙏❤️😊❤️😊😊❤️

I love your videos they are so creative as I'm a visual learner, It helps a lot in Med School.

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Am I student and wow...ur videos are really helpful....Was asking u guys to make a video on protein purification methods as well

I think something is off about the Competitive Inhibitor. If the Substrate Affinity goes up, the KM decreases, but as the Substrate Affinity goes down the KM increases. You explained that to beat the Competitive Inhibitor the Substrate Affinity must go up thus the KM will increase. No, I think the correct explanation is because the Competitive Inhibitor beat the Substrate's Affinity, the Substrate Affinity goes down hence the KM goes up. Because the effect of Competitive Inhibitor is KM goes up but Vmax unaffected. That's all from me, anyway amazing video! Really helps me understand difficult concepts!

This is amazing 🤩 Thank so much ninja nerd for making all these biochemistry lecture videos I really appreciate it 😊 could you replace my lectures on my biochemistry module?🥺

Explanation really very clear.Thnks a lot

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Very helpful video .thank you sir.

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Sir your lecture are brilliant and easy to understand.... and one thing I have request you to upload a snap of lecture you've done on board.... it is easy for revision also.....🙏

I'm a french student who's not good at english but i understand everythink thank you for this video

Thanq for preking up the learning process😊.I have a doubt :disulfiram used to treat chronic alcoholism is an example of what type of inhibitor?

Love it. Thanks, Z.

You are the best tutor ever

At the end of the non competitive inhabitation, how is the inhabitant released and the pocket fixed or removed?

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Sir plz make a video on metabolic acidosis and alkalosis...and buffer system

Could you please make a nucleotide synthesis video? I really miss a nice and well-explained biosynthesis and degradation of purines and pyrimidines on youtube... Why won't you be the first? :))) Pleeeaasseeee

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careful! at 8:56! from what i understand, km has an INVERSE relationship with affinity. what's written on the board looks fine but when you say "km, or affinity, increases" is not!

Lehninger takes 3 pages to explain this. you make life easier bro. love you

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Dude, I just got an A in Biochem with the help of your explanations! I am eternally grateful! Greetings from Croatia ✌

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good explanation but I've got one question or one thing I don't understand. You said that when the substrate concentration will increase the Km will increase to and so the affinity. In the first part of the video you said that a high Km means that the enzyme has low substrate affinity. So how can the affinity become high in competitive inhibitor when the Km and substrate concentration increases?

loved the Cox joke at the end

Fantastic!

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amazing explanation 🤟

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The fact that aspirin is an irreversible inhibitor is actually why the dosage for aspirin as a bloodthinner is a lot lower than the dosage for aspirin as an anti-inflammatory drug, which I think is super interesting.

Hi is there a video on purine and pyrimidine metabolism?

It makes everything so easy . Really helpful ,keep going,😊

How can a certain amount of substrate in a cell be specific when there is different amounts of enzymes in a cell at any given moment?

Thank you Thank you Thank you!!!

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Thanks sir

Спасибо за мотивацию учить английский

You are the best✊✊✊

Sir I want notes what you write on board so that I can revise them.

Great explanation, nice job! But I am a bit confused here..... does this mean that in the presence of an irreversible inhibitor no catalysis will occur? I mean not at all? No matter the amount of substrate there is, non will bind to the enzyme? No effect on Km or Vmax?

Hi dr would you Please post the list of order of the lectures ?