This video discusses the crucial role of mitochondria in aging and the latest advancements in treating mitochondrial dysfunction. Here's a summary: 1. **Introduction to Mitochondria**: Mitochondria are tiny organelles in almost every cell, responsible for creating ATP, the energy source for cells. They are more abundant in high-energy tissues like the heart, liver, brain, and muscles. Mitochondria have their own DNA (mtDNA), which is highly susceptible to damage and plays a significant role in aging. 2. **Mitochondrial Dysfunction and Aging**: Mitochondrial dysfunction is a key factor in aging and related chronic diseases. It involves decreased ATP production, leading to various age-related diseases like metabolic syndrome, cancer, cardiovascular diseases, and neurodegenerative disorders. 3. **Mitochondrial Health**: Maintaining mitochondrial health is essential for extending health span. Early detection of mitochondrial damage is crucial as it's reversible at initial stages. Mitochondrial health depends on efficient ATP production, the number of efficient mitochondria in a cell, and effective removal of dysfunctional mitochondria. 4. **Traditional Approaches to Boost Mitochondrial Health**: These include proper nutrition, eating whole, organic foods, taking supplements (vitamins B, C, E, and minerals), and exercise, particularly high-intensity interval training (HIIT) that stimulates mitochondrial biogenesis. 5. **New Advances in Mitochondrial Treatment**: - **SS-31 Peptide**: This peptide targets cardiolipin in mitochondria, potentially improving mitochondrial function and ATP production. SS-31 peptides are considered promising in treating mitochondrial dysfunction. - **Nomad Mitochondria and Extracellular Mitochondria**: Recent discoveries show that mitochondria can exist outside cells and exchange mitochondrial content. This understanding opens possibilities for artificial mitochondrial transfer/transplant to rejuvenate aging cells. 6. **Mitrix Bio's Approach**: Mitrix Bio is developing a system to extract young mitochondria from stem cells and package them into vesicles called "mitlets," targeted for specific tissues. Their research showed promising results in rejuvenating the immune system in older mice. 7. **Conclusion**: The video emphasizes the importance of mitochondrial health in the aging process and the potential of new therapies to extend healthy lifespans. It encourages viewers to stay informed about advancements in mitochondrial research and related rejuvenation therapies.
That's awesome. Now all you need are timestamps to take it to the next level for the truly impatient and the zero attention span people! hahaha - Cheers.
You could have also mentioned GlyNAC, probably the simplest, the most broadly available to the public, and the most efficient supplement to rejuvenate mitochondria. I've been taking it for 6 months, as per the human trials regimen, it works wonders.
glynac works thrugh a very different and indirect mechanisms sure , itt elevaes glutathione, which is very important, and in the long run it can prevent damage to the mites. but that is, as said, indirect
Wow... If I understand this correctly, then the higher energy demand of exercise 'exposes' weak mitochondria for destruction - creating a quality-control effect within the host cell. So, even a little bit of exercise is greatly beneficial - even if you don't lose an ounce of weight.
Thank you, Lance. Great video. Though you did not mention great benefits of sunlight ar artificial IR sources for mitohondria. A lot of reaserch has been done on this issue. Sunlight, mostly IR, IS REALLY A POWERFOOL TOOL.
Very great information! Just want to check with you about doing HIT workouts for regeneration of Mitochondria. From what I've been researching, it seems that Zone 2 training is even more optimal in the regeneration of Mitochondria. Both types of exercise helps in regeneration but it's more optimal exercising in Zone 2. A bonus too is that you can do this type of exercise daily because it doesn't stress the body to the higher limits. Ideally you could mix both HIT and Zone 2 in the right dosages to keep you exercising well into your golden years. If you did only HIT workouts.......this would lead to higher chances of injuries and burn out. What are your thoughts?
@@LanceHitchings Yes i forgot to mention that too because strength training is very close in importantance along with Mitochondrial health. They go hand in hand. Just wanted to let others know they don't have to do HIT workouts for Mitochondrial health. Easier Zone 2 work outs work just as well, if not better. Plus they are alot easier on the body according to Inigo San Millan.
@@caryEUCNutbar Just gotta say, I'm a huge fan of HIIT. While I've sustain 2 injuries doing steady state cardio, I've never injured myself doing HIIT. At 74, I still do them 2 or 3 times a week. I love that I can get a great workout in as little as 5 or 10 minutes, as opposed to doing zome 2 workouts for an hour.
@@LanceHitchings I'm happy for you that you can still do these HIT workouts at your age. That's awesome!!! But i can tell you that if i told my older parents (81 mother and 86 father) that they have to do HIT workouts....... they would not work out at all. But when i explain to them that they can do low intensity Zone 2 walks. Then they are open to doing these because they can handle the workload. They are also doing resistance training as well. Your article was about Mitochondrial health for the aging. So that's why i had to make the folks know that lower intensity will work as well. I do agree that HIT workouts are extremely great too. I use this as icing on the cake. The Zone 2 allows anyone to build Mitochondria and the HIT workouts take it up a notch or 2. But HIT only workouts will make it harder for some to do this into their 90s or 100s agewise.
What advice is available for someone who has had mitichondrial dysfunction and depketion for 18 years, so many mito have already died? What should I do to improve those that are left. Im disabled and nearly 80 but very keen to improve my health.
Yep, my mom lived to 98, ate crap food and never exercised a day in her life. Did nothing but watch TV the couple of decades. But had she chosen a healthier lifestyle, she'd still be with us. Exercise will absolutely lower your risks of all-cause mortality. That's been proven.
I have fluroquinalone toxcity which is mitochondrial disfunction. Weirdly my atp levels are normal but I have high oxadative stress and low mito! Will ss31 help?
Eating healthy for mitochondrial health is almost impossible for someone older on minimal disability income as extreme organic food costs do not lend itself to low income recipients.
While eating organic is healthier than non-organic, simply eating whole foods instead of overly refined and processed foods with lots of additives is still WAY healthier.
There are ways to improve no matter income. I grow some things myself. Container garden. Watch for sales. Community markets or community gardens. Whole foods.
Get enough sleep Intermittent fasting Reduce stress Eliminate processed foods and sugars Exercise - especially HIIT Get out in the sun Get some sunlight in your eyes first thing in the morning None of these cost money.
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