Click here for the full video: Robert Lustig, MD - Food, Metabolism, and Psychiatric Disease 

I love uur talks

Dr. Robert Lustig has saved my life and he is saving the world.

4 months ago I was diagnosed with type 2 Diabetes. My HbA1c (blood glucose) was 73 mmol/mol. Since then I have moved to a mainly wholefoods diet with little processed food and no UPF. I eat many organic things where possible. I eat strictly pumpernickel for bread, no refined carbs, no potatoes, ZERO added sugar and control carb portions to around 50g per meal. I enjoy cheese, fatty natural yoghurt, whole milk and snack on nuts, which keeps my fat intake at a good level. Kimchi, sauerkraut and yoghurt help my microbiome. I have also done a morning workout (exercise bike and weights) 4-5 times a week and have taken 500mg of Metformin twice a day. In 4 months I have lost 17.5Kg/2St 10lbs/38.5lbs and my blood test results today show a HbA1c of 36mmol/mol, which is amazing!

He's so right. It's profit before people. We The People must drive this.

My brother was diagnosed with schizophrenia 4 years after moving to USA. Growing up on a completely Asian diet then converting to a standard American diet living in a dorm , feeling homesick and alone didn't help. My mom claimed for years that coca cola gave him the disease. Now science has caught up to her wisdom. He was a concert competitive pianist and brilliant beyond belief, true prodigy.

I'm going to need to watch this 5 more times.

Robert Lustig an amazing Genius. The man has knowledge that can actually change the world.

Been listening to everything I can find with Dr. Lustig recently and he is both scaring the heck out of me and inspiring me to change my life and diet. Thank you for posting this.

Dr. Lustig is just awesome. I’m a biochemist and struggle with depression so I enjoyed this one A LOT. Thank you!

I love Dr. Lustig, he changed my eating life style..3 years carnivore, extremly healthy! my Dr sees my blood work comments excellent health.... see you next year!! i am never sick not even a cold!! Thank you for all you do to change the health care industry! Keep going!! God bless!

Twenty years ago, when I was a student, I participated in a study where they observed what happed in the brains of obese adults when they were given fructose-sucrose via IV. The MRI was done three times, with one time being with a placebo. The subjects were also asked to guess when they were given fructose and when not. Yup, I sure did know!

Excellent presentation. True that behaviour inattention increasing in schools. School meals have become all fast food, nutritionally poor, ready meals. What effect for the children?

Wow! I will review this video over and over for it’s great detail and information - for the rest of my life. Thank you for the work you’ve done.

Every time I hear Dr Lustig I learn more and feel I am in control of my health

I could listen to this guy all day, he's so brilliant but still makes it understandable for everyone.

❤ - Why is this so hard for “others” to digest?? The world needs access to this knowledge

Dr. Lustig has turned my life around, Stopped eating all foods with High Fructose Corn Syrup. My A1C was 6.2 five months ago. Also stopped all seed oils. 68 years old, With change in diet, I am counting calories, to match my age and highth to loose weight the right way. I have lost 25 pounds, My A1C is now 5.6, My Doctor had talked to me about loosing weight to try keeping from going on another medication.

As always, the simple principle is GIGO: garbage in/garbage out. The only real discussion is what is garbage and what is not (food, diets, behavior, etc...), and Dr. Lustig excels at tying it all together and the picture begins to become more clear for the clinical community, and more slowly, the general public.

Dr Lustig is a true American Hero!

Always enjoy Dr. Lustig speech, wish I were there.❤

I love Dr. Lustig and follow him and keep myself healthy. I worry about his health because of size of his stomach. How about a MRI to check the visceral fat?

A study with a ketogenic diet or sugar free diet in people with Alzheimer's would be easy to do and would rapidly show results and would be of great value to society.

Emery Pharma Your RU-vid Videos are a great blessing! Dr. Lustig raises our awareness about what food is *made* of! Greetings from Germany 🇩🇪 😅

He is the best Dr on the internet.

" _.....even the Lancet guys have figured this out - and to be honest with you they have figured much of anything else_ " Dr Robert Lustig 2023 *So true !*

I love that Dr Lustig is now also talking about mental health!!!

Wow! Thank you! This was a critical eye-opener for me trying to heal from a chronic illness.

Thank you for making this presentation available. 👍🏻

I like his sense of humor, lol, I've learned so much from this man and I'm still learning from him!

Dr R L talks I lessen. Lovely gentleman

Love love love Dr Lustig!!!

34:45 ...a compound that is made from an intermediary metabolite of fructose called methylglyoxal. It is the breakdown product of dihydroxy acetone phosphate. Okay, it can fit in that active site and it is an aldehyde. And what happens when an aldehyde and an amino group find each other? Right. So, here's the Maillard reaction. If the rate of the glucose at the Maillard reaction is one, fructose is at seven, methylglyoxal methylglyoxal is at 250. So methylglyoxal methylglyoxal is a bad guy, okay? Because it is binding to proteins whether you like it or not, okay? and it fits in the active site, so it fits in that AR you know, finds one of those arginines in that active site. So, the methylglyoxal gets made from dihydroxy aone phosphate from fructose fits inside there and then you turn off your AMP kinase irreversibly! You have basically killed your AMP kinase. So, your AMP kinase goes down; what does that mean for mitochondrial biogenesis? It means it's in the sewer; it means you have decreased your mitochondrial function. and if you decrease your mitochondrial function, what does that mean for your cell? It means your cells are starving. And is that going to have any behavioral effects if it's in your brain? You bet it will!

Best presentation yet thank you Dr. Lustig. And thank you Drs Palmer & Johnson.

This knowledge can change the word...back to how our brains worked before the industrial food revolution

thanks Prof Rob & all emery pharma team 👍👍

It's not just sugar. All carbohydrates that can be digested have the same effect.

Congratulations Mark! I too sent my ALT plummeting to 18, one time 17 by going keto. I took Dr. Lustig's advice on limiting sugar, plus wheat, corn, rice and soybean oil to 9 tsp/day. My honey limits the aggregate to 6 tsp/day. The result flipped our health to where I can mow the yard at noon, without a break, in the middle of an Orlando August. Mentally I can read without wandering so comprehension is better.

What a great teacher! And proven science researching for real food and thank you for sharing this information from Johannesburg South Africa 🇿🇦

I got a second chance to life much thanks to Lustig and like-a-likes. Still time has shifted my focus less towards a diet. I have been low carb, keto and carnivore more than ten years. Now living no plants lifestyle with flawles un-illness. This is not the big picture. Not even close. Melanin explains everything Robert says. Why do not people see it is my conundrum. My focus has shifted towards POMC, leptin-melano cortin pathway in bioquantum frame work. I have a solid state optoelectric research background in semiconductor research. QuantumHealth seems to be underlying the chemistry and biology found to manifest these problems in the foods we consume. I claim that in real life we consume the light from the skies and transform it to energy by mitochondria and food exacerbates the machinery to enable all this. It is a story of light at first principles. It is the Light I see under the topis what Robert talks about. Blue light toxisity messing with circadian signaling, resulting in mitochondrial dysfunction. Some issues with pestisides and plants own phytochemical warfare in foods interest too. Not to forget the deuterium factors in this wide-band semiconduction hypothesis. Food is only a barcod of the native EMF we get from our star during any day and night plus the UV-frequency emission every cell makes with melanin when the sun is not shining. That is the bactreria and eucariot connection. Signals that are coherent. Where do you live? Do you eat food of that latitude?

Great talk, as usual. Thank you!

Another amazing conference

Dr. Christopher Palmer, "Brain Energy" Dr. Matthew Philips Dr. Georgia Ede

لقاء في القمة....شكرا جزيلا

The true definition of what being a doctor means !

How lucky you are to have had him grace your presence! (Ok that’s a lot but heeeez goooood 😝) ❤

Hi! Thanks for the video :) will keep an eye out for updates

Neurological specialist in London always said they didn't know the reason why my mum and brother got sick with motor neurone disease, my brother being obese had it 20 years earlier than mum. I am sure that living by a ketogenic diet and moderate exercise is helping my brain and hopefully I will not be affected. It seems increasingly the case given all the studies and facts I'm hearing, that I'm now more aware of the cause than the specialists in London.

Dr Lustig is inspirational providing knowledge to empowering us to make better food choices 🙏🙏

SORBITOL CONVERTS TO FRUCTOSE! SORBITOL IS THE KEY INGREDIENT IN MANY "SUGARLESS" CHEWING GUMS! THIS EXPLAINS A LOT!

I love Dr. Lustig's videos, no matter how lengthy they are--his videos are like medical school lectures. I must have watched just about all his videos, and take notes from his videos. I have read his books, METABOLICAL and FAT CHANCE and his recommendation PURE, WHITE and DEADLY by John Yudkin. With his very educational videos, Dr. Robert M. Lustig MD is saving lives. I recommend his videos and books to family and friends..

Amazing. Gratidão 🙏

Keto 10 months minus 56 pounds and 2 meds, keep it simple

So interesting. Thanks Dr Lustig.

Thank you Emery pharma!

I like how Dr. Lustig addressed the child's diet by making meals for parent and child. They were both supposed to eat. Kids can't buy their own food yet. Adults make the choices. As we heal ourselves, kids, grandchildren stand a chance.

Great job

Rob's a master of conveying such complex subjects.

So much info! He’s a treasure

Excellent information!

Ultra processed foods could be made healthy but I don't believe they could ever have the shelf life required to get them ON the shelf.

Nice work…

Dr. Lusting, I am a long time follower and love your lectures. What is the easiest way to eliminate fructose? Fruits have fructose too? What foods besides processed foods shall be eliminated.

Fabulous presentation! Will need to watch again though. :)

I cured my 7 year old child's Tourette's Syndrome with a natural diet. The child took antipsychotics because the tics were very severe. Now he is healthy and does not take medications. I started by cutting out excess fat in my diet, then reducing my intake of sugar and white flour. I'm happy, nutrition is incredibly important! Health to you all!

I have huge respect for Dr Lustig but I was surprised that he advocates keto. He says he does it because the jury is still out on whether it's the keto or the elimination of sugar that has the positive effects. But I read the Yudkin 1974 book Pure, White, and Deadly that Dr Lustig recommended elsewhere (and wrote the introduction to) and it talks A LOT about studies comparing sugar based diet to starch based one. It seems to have already answered the question whether it's the keto or the elimination of sugar, way back by 1974. It also talks a lot about the importance of using animal models that are omnivores like us, otherwise you don't know if the negative effects is simply because you're just feeding the animals stuff they don't eat in the first place. I don't know if fruit flies' natural diet is sufficiently close to the human one, but rats are, and they're mammals too, so this gives the opportunity to study for example pregnant rats and the effects on their babies, which Yudkin also talks about. Keto is also known to be contraindicative for females (at least in fertile age, because it disrupts hormones) and absolutely so in pregnancy, so I was surprised that Dr. Lustig didn't mention sex differences throughout the whole talk, especially given that 2/3 of AD patients are female. Just think about it, the diet that best promotes baby's health and development in the womb is most likely the best diet period, and conversely, if it is contraindicated, this should give anyone pause. Dr Lustig also mentions the negative effects of meat but not that it is nutritionally challenging to be on a keto diet and vegetarian (unless you eat copious amounts of full fat cheese etc, the health benefit of which is dubious) and virtually impossible to be keto vegan, because pulses like lentils, beans, chickpeas don't pass the keto threshold, restricting the only source of protein to nuts and seeds. As another doctor mentioned, every known culture on the planet historically has eaten starch. The problems observed today correlate with the advent of sugar in human diet, not starch. This is also proven in generational studies of migrants to the US and their children. So I'm not convinced that keto is the answer. No fad diet can beat good old plain real, whole food, in moderation, combined with physical activity.

How would an undiagnosed chronic Candida infection in the small bowell affect mental health?

I found sugar in my kombucha, in my canned vegetarian beans, in my stewed tomatoes. I try to completely avoid all added sugar and ask my clients to do the same. Its increasingly difficult.

Great lecture

We can be the change we want to see.Its imp to talk to people and give them ur time. U never know how Your simple act of lending a ear even to strangers might help them feel accepted and lessen their worries

People in Hong Kong live 8 years longer than we do. They eat lots of vegetables, lots of seafood and meat, way less sugar tha we do.

What makes this here Lustig's possibly best fitting form of presentation to aim at deniers? It's to the lesser demanding of a certain level of understanding by being directed more broadly and general, while it's still including the "to be continued" (glucose versus fructose) that even if amazingly so is sought to be hanging very loosely in the ear. Not even health specialists are much involving it at all, not even while informing of the obesity risks that's concentrated around the will or the lack of will that's no doubt wrongly and irresponsibly focused in directly harming manners, let alone the fructose's work on dopamine that'll soon get one kinds of very little amusing attention where "sweet is our culture" seems still to be representing a wall that's making for incredibly much of an impenetrable landscape.

Dr Lustig - I love watching your talks... but please address your bulging gut ....we want you to remain well.

Dr. Lustig is a giant.

Another great presentation. I am confused about the association between glucose and fructose. Is there an introductory level video that reviews this in more detail? In particular, how the the body processes both molecules. Thank you very much

After almost a year of hearing his lectures i finally gave up the white sugar. I do the green one sparingly and I drink diet colas. My next step is to get off the green sugar packets and to give up soda. They say sugar is harder to quit than illicit drugs and i believe it 😊

Love him 100% great Doctor!!!❤

25:22 Glucose actually stimulates mitochondrial function. So, you'll notice beta oxidation up arrow in green, hooray! that's good. Glucose increases mitochondrial function. How does it do it? It activates two enzymes right here. IT ACTIVATED AMP KINASE, adenosine monophosphate kinase; this is the fuel gauge on the liver cell. When your cell uses up ATP, it makes AMP, right: Because the phosphate bonds get broken and that's where the energy is; it's in those phosphate bonds, that's what the electron transfer support chain in your mitochondria do. It's they basically release the uh uh energy and you turn into NADH and then go back and forth, Etc. You know, that's that the whole oxidative phosphorylation that powers cells. everybody familiar with the concept? Right? Okay well, AMP kinase. Okay if you have more AMP, it fits into the active site and what that does is that tells the cell "not enough energy, we're energy depleted because I've got AMP instead of ATP. And so, we need to make more mitochondria." So, it increases mitochondrial biogenesis, which is good for burning more energy. In addition, it increases this enzyme here called HHDH hydroxy acetyl COA dehydrogenase, which is also involved in increasing the rate at which two carbon fragments get converted into energy. Thus beta oxidation go going up. So, glucose for lack of a better word is good . Fructose on the other hand is another story. Fructose does the opposite; fructose inhibits three enzymes that are necessary for normal mitochondrial function. [It inhibits AMP kinase, it inhibits ACADL, and it inhibits CPT 1A.]

Great 🎉😊 aprendí mucho

I know more than the doctors thanks to talks like these

Danke

Xylitol inhibits the growth of streptococcus mucans orally. Should we replace cane sugar with xylitol? What is the effect upon the gut microbiome ingesting xylitol?

@07:30 Ketones are transported by MCT cell surface protein, which are always expressed in cells and function without insulin activation. See Wikipedia article Monocarboxylate transporter.

Podrian poner subtitulos en español..❤

Why is it that some doctors only talk about sugars and it’s effects on health only when they retire ?

Looks like the good doctor has been hitting the donuts.pretty decent gut there.

Yes it's very typical when you get rid of the carbs that you are good LDL the big fluffy ones will increase which will then give an overall increase in the total LDL number that's why you have to have your doctor break that particle number down so you know which one you're dealing with

So based on what he said at around the 1:14:30 mark, how high is a medium carb diet and is he talking about letting bad carbs slip back in and not fruits and veggies in a whole food diet? It doesnt take much to go up in carbs but if they are clean, mixed with a high fat diet, is that still a recipe for disaster???

I've found that increasing my animal fat intake greatly reduced my "snack cravings" in-between meals making my OMAD "ketovove" diet much more doable. This may work for others who suffer from snack cravings between meals.

I’m mind blown

Dr why don't you allow lentil soup on your diet or soups

How do you get the slides ?

If glutamat is a player in the biochemistry is glutamat as part of many hpc products dangerous in itself?

No ketone receptors or transporters? SLC16A6? HCA2?

at 46:00 Lustig says that insulin inhibits leptin signaling, ive been trying to find papers that confirms that information but without sucess, can anyone help me out?

Goddamn Hero this guy, few people with this character , modern hero i say

One question for Robert - if Fructose is so deleterious to Human metabolic health why have we evolved such an enhanced _reward_ response to it ?

Does anyone know what he meant when he said “a partial keto diet is worse than not doing a keto diet at all” ?

Is the upshot that we shouldn't eat fruit?

I had my trucility 75mls today at 3pm dr

Where can you purchase Munch Munch, I have searched the internet and it is nowhere to be found.