David Sinclair on the Brink of Anti-Aging: Reprogramming Cells for Eternal Youth

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In this episode of the James Altucher Show, James dives into a fascinating conversation with Dr. David Sinclair about the groundbreaking research on aging and potential ways to reverse it. They discuss the intriguing concept of using low-dose medications for unexpected benefits, the discovery of DNA by Francis Crick and Jim Watson, and Sinclair's paper on the information theory of aging. The discussion covers the difference between genetic and epigenetic information, the possibility of reversing aging by maintaining or restoring the information contained in our DNA, and the remarkable evidence from animal cloning that supports Sinclair's theories. They also explore the current challenges and future possibilities of gene therapies for age reversal, including the reprogramming of cells using Yamanaka factors, the experimental use of specific chemicals to rejuvenate cells, and the potential implications of testosterone and other supplements on aging. Sinclair's pursuit of understanding the epigenome and its role in aging, alongside the practical application of this research in treating conditions like blindness and extending lifespan, provides a tantalizing glimpse into a future where age reversal could become a reality.
00:00 Exploring the Unusual Uses of Viagra
00:12 Introducing the James Altucher Show
00:24 The Fascinating World of DNA Discoveries
00:46 Unlocking the Secrets of Aging and DNA
01:46 The Revolutionary Concept of Age Reversal
02:21 The Potential of Epigenetics in Reversing Aging
05:36 Exploring the Possibilities of Age Reversal and Genetic Therapy
05:55 Navigating the Complexities of Gene Therapy and Regulatory Challenges
08:21 The Future of Aging: Supplements and Scientific Debates
12:17 The Cutting-Edge of Age Reversal Research
18:55 The Intricacies of the Epigenome and Age Reversal
24:34 The Promising Horizon of Gene Editing and Age Reversal
28:56 Exploring the Future of Viral Gene Therapy
29:08 The On/Off Switch for Viral Therapy and Its Potential
30:13 Understanding Aging and Cellular Reprogramming
33:18 The Brain's Learning Capacity and Aging
35:35 Reversing Aging: From Theory to Practice
43:32 The Path to Human Trials and Regulatory Approval
47:33 Exploring Off-Label Uses and Future Applications
49:32 Testosterone, Aging, and Other Health Insights
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Опубликовано:

10 июн 2024

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Комментарии : 147

@tocitim Месяц назад

David, don't stop...Do the miracle

@georgiaparaskevopoulou7425 Месяц назад

Keep doing that!!😊

@tocitim Месяц назад

@@georgiaparaskevopoulou7425 how are you Georgia?

@georgiaparaskevopoulou7425 Месяц назад

@@tocitim I am doing well thsnk you!!😊

@jozette-pierce Месяц назад

At least help us keep our eyesight. I have lots of work to do. Thanks, David.

@wideningcarrot6 27 дней назад

@tocitim on the tune mate 😉

@dannyozuna Месяц назад

Yes, I'm ready for the upgrade!

@karl3630 27 дней назад

The most incredible thing is that we are not that far away from reprogramming our cells, and he 's proved it. He's at the cusp of maybe restoring sight to human beings, what an incredible feat. My biggest fear is that there are many people out there who will do whatever they can to jeopardise his work, not because they can do better but out of simple spiteful jealousy! Remember every single human being on this planet will get old one day and suffer everything that goes with it, if we can do something to negate that outcome not only do we profit but all the generations to come. It is far better to prevent these illnesses happening rather than treating them with dangerous drugs, which profit nobody but the pharmaceutical industry.

@the_best_of_times 14 часов назад

Love this. Your enthusiastic "when?" and "would you do it?" and wouldn't a lab in China be doing this already is a baser line of questioning you wouldn't normally find in most podcasts. Good on David for playing along and not hiding from these questions.

@tocitim Месяц назад

David, don't stop doing it...

@pgc6290 Месяц назад

At 5:30 and he is just a small kid/student asking questions. I like that. He is still so young in his brain.

@DrJK-wm9ec Месяц назад

David Sinclair has lost a little of his pixie dust because of a few missteps. However, there is no denying he is pushing the Longevity space in a new direction…looking at Aging as a disease, the hypothesis that there is of a back-up copy in cells that could be used to reverse aging, and more. I do hope Dr. Sinclair does stay focused on his research and keeps pushing the envelope on Longevity science!

@aratonit9551 Месяц назад

What missteps are you talking about

@Preciouspink Месяц назад

Why does this doctor go on so many different shows? Does this impair the ultimate goal of treating aging?What does he accomplish with all this video attention?

@InfinityCelestial 27 дней назад

@@Preciouspink scientist

@SquatFull 7 часов назад

Balderdash that requires credulity to believe.

@joeblow2183 Месяц назад

Great interview. Thank goodness the nmn protocol was held to a minimum

@peterm5554 Месяц назад

Great news about clinical trials curing blindness in human eyes starting next year. They are already talking to the FDA and see no show stoppers. This time next year (May 2025) they could be calling for volunteers for the trial. Hopefully once blind people see again the penny will drop and everyone will understand that age reversal is real and more research money will flood in so that we can all become young again as soon as possible

@louiscomadena3230 10 дней назад

@peterm5554 Hi I'm Louis from Virgina Are you excited To witness the reversing blindness age of the eyesight Next cause hell yeah I am where did you get your information

@adamal-hilali6497 Месяц назад

Love this. James has ability to ask everything you want to know, brilliant

@pgc6290 Месяц назад

At 34:29 and yes mindset and brain are vary important.

@Rose-vp1sn 9 часов назад

This has been the most informative video thank you

@jorn-michaelbartels9386 3 дня назад

Dear David, I am waiting and hoping on your miracle. For my wife’ s and my daughter’ s sake, I wish to get 100.

@keithmarshalldds511 Месяц назад

Would red light therapy be helpful as viagra for endothelial health? I would think even more so due to its direct effect on mitochondrial function.

@INDIGE_STUDIO Месяц назад

Only meat eaters need viagra quit meat and eat plants and boom your young again down low 👌

@WackyGameEngineer Месяц назад

Sinclair i bet my Life on you! Keep going :)

@chaddy-me-boy8299 9 дней назад

Can we sign up somewhere to get the latest papers David or his group comes out with?

@pgc6290 Месяц назад

At 1:22 and imagine if we could go back to who we were mentally.

@KLTer-jo9jy Месяц назад

dear lorde, imagine we'd all be dumb teenagers again. Please, no.

@bkb2012 Месяц назад

Fabulous!

@jordanong5114 23 дня назад

We need to do more. More progress for the business in the present and future.

@labrenzjasmin85 22 дня назад

fantastic

@armankilic 8 дней назад

I guess David is standing up during this video.

@KenNelson-ln7iv 8 дней назад

Hi David! 5:24 1. How do you eat olive oil? 2. Do you eat sandwiches? 3. Do you put half & half in your coffee?

@clearlyaudible Месяц назад

15:10 good question, my question too

@tudyloco1726 Месяц назад

Question is is where in the body is the control system in the discovery of an upgrade and update of the new control system where is the component is it the brain or is it beyond that cuz now I'm hearing our gut has a lot to do with aging

@tedchapple5991 Месяц назад

Where is the reference to a published paper showing the documented success of a cloned monkey living out a normal lifespan?

@WILLIAMMALO-kv5gz 24 дня назад

It may be helpful to look at the higher electrical level as in the work done by Dr. Micheal Levin PhD Microbiology. This also may tie in with "Electric Universe theory" to some degree. Thanks to Dr. David Sinclair and James Altucher for this very informative video.

@edwardbearjames2916 Месяц назад

So then comes the idea could he clone himself? Could you as long as you got along with them still get potential anti-aging help from their blood plasma? Then comes the question of cloning and the rights of the other person and all the others that comes with. How much longer could someone live if they were given younger blood of their own? How many clones of your own could you make?

@clearlyaudible Месяц назад

37:00 from 5 down to 2, and now only one small molecule to permanently reset your age ? interesting 🤔

@xeniastefanescu507 19 дней назад

What about taking Nitric Oxide or Taurine.,for increasing testosterone?

@Ruudjee 10 дней назад

I do not know the molecules he found, however, I do know that partial reprogramming can make cancer more aggressive by turning cancer into cancer stem cells. Cancer detection tests must be way better than now.

@joecool7165 Месяц назад

David, I followed you for a very long time. Your eyes blink a lot now and they just don’t look right. I hope everything’s OK with you have a lot of hope for what you’re doing.

@SAMSAM-rw9fc Месяц назад

Wow you are a very good judge I watched this video for a long but didn't notice his eyes after I thought let me read the comments and here you are lol really his eyes are not looking just right IDK what's happening. Btw Im on NMN for 2 months I don't feel any difference but as this is just 2 months I'm continuing Have you started any same kinda supplementary, I would appreciate sharing thanks

@andrianasotiris6681 Месяц назад

@SAMSAM-rw9fc Botox is what's wrong with his face

@js401 Месяц назад

Try going to a gram and a half of NMN.

@SAMSAM-rw9fc 28 дней назад

@@js401 Its written on the bottle one capsule a day so I'm following that Can you please answer if you taking any that kinda capsules of NMN if yes what brand? I'm taking "PartiQular"

@Melungeonpeople 28 дней назад

It could be as simple as a draft in the room.

@marcusiA-immortalistMarcus Месяц назад

😁😁 I love it

@magsharper3268 28 дней назад

Can you recommend a preferred brand?

@SAMSAM-rw9fc 27 дней назад

If you find a good brand pl lmk btw im taking PartiQuar past 2 months not sure if good or not

@henryjraymondiii961 26 дней назад

What about programmed senesence, the telomeres shorten and it seems to be more than wear. Are we indicating that fundamental lengthening of telomeres has been done in experiments? Otherwise, there seems to be a "clock" that indicates programmed death by a body calendar. An actual time-senesent truly time aged rat may have a body clock that references an aspect of...time...that is not being addressed by artificial ageing tecniques. As scientists and anti-aging proponents, we need to have begun to look at this in a real time manner, because the time it takes to know the proven coucpome of such validative measures-- now THAT could get "expensive" in terms of lost lives. Lets proceed as individuals to try--but we also need this for the future.

@rigwatvchannel4458 26 дней назад

It is interesting and adventure in science Cells are key if programed age can be recet Resuch is possible

@ussupplyllc5161 26 дней назад

Or someone who is dying in 6 months should not become young because what if he dies in 3 months? FDA should allow exceptions

@eshaniking4421 22 дня назад

What I would really like to know is how much more effective any of these approaches are at increasing longevity and reversing ageing than a series of simple 72+ hr water fasts.

@AlexLacorum-hf9ie 12 дней назад

Claiming fasting reverse aging s still inconclusive and does not have scientific backing. If their is already on going trials then it will take a lot of years before we can see it's effectivity in age reversing. David Sinclair works is already taken laboratory experiment so it is more reliable than fasting but still need more time to find out how safe that drug to human

@brosan5404 23 дня назад

43:03 David Sinclair does an age reset live

@vicfarago4091 День назад

left eye appears smaller than right eye

@keithmarshalldds511 Месяц назад

Is it a coincidence that the URL for this podcast have three 4s? Lol

@feltonhamilton21 Месяц назад

I believe free radicals should be studied more often because they put out negative waves that can get in the way of signals and charged particles pretty much everything inside the body of a living cell and stop the positive activity between molecules and other particles creativity. Unpaired electrons can carry a negative charge for a long period of time while injecting negative energy and causing confusion between molecules and charged particles and stopping them to not line up with the inner and outer cell structure and work accordingly with the cell inner umbilical cord duplex protein adjustable scaffolding operating system designed to liquefy molecules and deliver them through activities on each contact with the cell inner wall but because there have been damage to the cell internal an external tissue they begin duplication on damaged and dysfunctional tissue, so rather than breaking away into two separate cells the cells clump up into a waste field powerhouse injecting free radical material into the bloodstream and eventually causing damage to other fully developed cells outer surface and enter body. I believe stopping unpaired electrons from doing any type of damage could be much easier than looking for alien resources. I believe it's all about negative and positive charge particles and reducing the wavelength on unpaired electrons and stopping the confusion with a stronger microwave input that can convert into a negative and positive charge and balance the entire waste field of decaying cells so white blood cells can take over and stop free radicals waves interference on the human DNA and from blocking biological digitally coding from positive electrons and molecules and other particles trying to stay charged and keep up with creativity..

@MarkShinnick 27 дней назад

Look into Sinclair's financial and claims history: many not happy with his ethics.

@BjJackson-jr8jz 26 дней назад

Time is what causes ageing.no scientest or person can not stop,reverse,or extend time which cause the ageing process in every thing.

@anirecapped. Месяц назад

Dave WILL outlive his critiques (unless he gets hit by a bus or something) since most of them are crusty old men, with one of their feet already in their graves, lol. But they do raise some valid doubts about some of his claims, especially when it comes to Resveratrol as repeated attempts to replicate your claimed findings have yielded zero results.

@awestaguetherealtor1520 22 дня назад

We love David Sinckler

@semaaral2498 20 дней назад

Yess missed him💙🔬🐭

@blackpepper8941 Месяц назад

37 very important...

@ussupplyllc5161 26 дней назад

someone who is blind, should not get a young vision in fear of maybe getting blind? FDA wants safety?

@RogerMimi-yq2ny 25 дней назад

Isn’t There some historical discussion about crick and Watson being first to discover DNA ??

@FrankPSF 28 дней назад

I'm 67 and just beginning to show some senescence. Sign me up!!!!!

@antoniobortoni Месяц назад

Why people put limits, anything is possible, but the gold rush is here, return to young treatment people will go to another country if illegal , so make it free and public the return to young mix and all, because i want to see all women young again, and at the same age all...

@cynthiaaiken2424 18 дней назад

how does joe average get in on a trial?

@josselynpierce4099 Месяц назад

I love ur work david sinclair plz study on me

@monaantony9096 25 дней назад

How about just buying a copy of Dr Furhman , Dr Greger , Dr Goldber and Dr Neil Barnard and follow their food guides and we would need no pill n so much research Just eliminate processed food for a start … it’s that simple

@DG123z Месяц назад

Can't wait until they have something you don't have to "believe in" for it to work

@vickybiagini8623 Месяц назад

You might be waiting for pigs to fly first. Hate to be like that, but it's been decades, and he has nothing, absolutely nothing. He has to keep the gravy train rolling though.

@DG123z Месяц назад

@@vickybiagini8623 They have something promising with the three yakanama factors and there are other avenues, such as with Michael Levin's work

@Preciouspink Месяц назад

Why does this doctor go on so many different shows? Does this impair the ultimate goal of treating aging?What does he accomplish with all this video attention?

@SAMSAM-rw9fc 27 дней назад

Good Questions I always was thinking that

@lumanliu8457 24 дня назад

@@SAMSAM-rw9fcfrom a positive thinking, I think he want to raise his fame and raise money for his business. You can imagine this kind of human trials need a huge amount of money and you know what's more important than the money? People's faith. Now, no one believe aging can be reversed. So no trial will even begin. That's I believe what he wants to change. One thing you can trust is that he is not doing those only for money. Come on, money does not mean too much for people at his position.

@brianlebreton7011 25 дней назад

James keeps referring to the DNA being corrupt which is not what David’s theory is. It’s the epigenome that’s not working right. David’s being very politically correct in not correcting him.

@ScaleCrawling 19 дней назад

1. Will you call it the T-Virus? 2. How young will it make Milla Jovovic look?

@DG123z Месяц назад

"No, i don't".. "okay" 🤦 it was some lady before them though anyway

@blackpepper8941 Месяц назад

Lucky enough to choose Biology as my career ❤, Even AI can't replace my career 🎉

@pgc6290 Месяц назад

Are you sure about that?

@gdok6088 27 дней назад

With AlphaFold AI and just recently the release of AlphaFold-3 developed by Demis Hassabis and his team at Google DeepMind based in London, UK 🇬🇧 you will certainly have some amazing and open-source AI to assist in your biology career.

@dovigliopagnoni3179 12 дней назад

Way you don't talk any More about NMN

@karinodendaal5277 25 дней назад

Not correct Info Dave. Molly the cloned sheep did not live a normal heathy life. She and all other animals cloned only live half a life span. They don't live a long normal life.

@KapowskiGG 28 дней назад

37:00

@jaykraft9523 Месяц назад

it's gotten to the point where I cannot believe a word this man says.

@pavanlulla Месяц назад

..snake oil salesman...David Sinclair selling Resveratrol 😂

@jaykraft9523 Месяц назад

and NMN, both worthless.

@joannajohnson5570 Месяц назад

So why are you here?

@larsnystrom6698 Месяц назад

@@jaykraft9523 It's a B3 vitamin. An expensive one. And as any of those, it increases the NAD+ level. So, who knows if it does anything for longevity. No research has shown that yet. Not even any mice research.

@jaykraft9523 Месяц назад

people need to weigh in and express doubt, but I thought that was clear to anyone with a brain

@techw4y Месяц назад

This guy is a charlatan, be careful of what he says.

@lorettareagan7705 Месяц назад

Did Dr. Sinclair seriously just say he’s okay with individuals committing suicide “as long as they are mentally stable”??!! Seriously, mentally stable? What a line. I used to have some respect for him. Not any longer. Think about the statement…suicidal, yet mentally stable? I don’t think so!

@unrealread5579 Месяц назад

I think... hope.. he meant medical assistance in dying.

@EkilRevolution Месяц назад

i disagree with what he said about suicide as well . i wonder if people who say such on suicide are projecting their personal struggles in life .

@bkb2012 Месяц назад

He's talking about end stage life.

@vickybiagini8623 Месяц назад

I thought it wasn't right either, but there are severely depressed people in the World.

@khushsingh973 Месяц назад

People have misunderstood Sinclair, as usual. He very carefully pointed out that suicide is not something to be taken lightly, nor to be dismissed out of hand, since personal freedom of speech and existence is ultimately sacrosanct. So, he’s suggesting that where life is so horrifically bad for an individual, but that individual is still able to make an informed decision on what is to be done given this level of pain, then it might not be our moral right to withhold whatever treatment is to be granted once all the ethical, legal, and physiological parameters have become addressed within some communal legislative framework. Including assisted death. This is an interview and he cannot go into pacifying everyone’s sensibilities regarding his view. Listen very carefully before jumping up and down and judging an intellect that’s operating at a cutting edge level whilst constrained within the law of the land. This is an extraordinary intellect with a highly motivated and complex mindset. He doesn’t need the respect of those who cannot think for themselves or about others who need the greatest care. He has a right to an opinion. That’s what freedom and diversity is all about. He’s not looking to win the presidency of the USA. He’s explaining and exploring what science and scientific endeavours could mean for everyone’s life. Let’s just listen…

@seanmchugh6263 День назад

nasty piece of work, this guy.

@t.t.8878 День назад

Is David wearing Make-up ?

@larsnystrom6698 Месяц назад

Hah, the video title is far from the truth. More fantasy than science, unfortunatly.

@TheNewOriginals450 Месяц назад

No, science, not fantasy. Maybe you don't understand the nature of incremental scientific progress.

@PetePH 28 дней назад

@@TheNewOriginals450 it has nothing to do with science. It is all about money. David is nothing more than a snake oil seller. You can see through that easily if you really know about science.

@kth6126 27 дней назад

Haha - and your studies to back your statement?

@shinkurt Месяц назад

He is a scammer. Listen to literally anyone else

@tudyloco1726 Месяц назад

DNA is like a shoelace after time its get worn down

@RandomGuy-lu1en Месяц назад

no. Thankfully that's not the case

@pitdog75 29 дней назад

He is a crook.

@PetePH 28 дней назад

Agree, recently learned about that. $720M made this crook to sell snake oil.

@WILLIAMMALO-kv5gz 24 дня назад

This world we live in, is full of crooks. Some are right some are wrong...Get used to it.

@pitdog75 23 дня назад

@@WILLIAMMALO-kv5gz amazing insight, I am enlightened

@yannlang4849 14 дней назад

Stop your bullshit and come up with your own solution!

@hannabarishnikova5496 21 день назад

I don’t like the guy

@richardbreeze7898 Месяц назад

Back up full genome copy. Somewhere in the cell. Do you guys actually buy this nonsense ?

@TheNewOriginals450 Месяц назад

What guys? What nonsense? Do you not understand the research?

@richardbreeze7898 Месяц назад

@TheNewOriginals450 So Where's the back up copy located exactly ?

@carlotulio3411 9 дней назад

he managed to rejuvenate the eyes of mice and monkeys with this procedure, which means that the backup copy exists. The problem is to get the retrovirus carrying the substances that trigger this process to all the cells and without triggering autoimmune diseases, tumors or anything else. Another problem is that these viruses, although they are designed to be "good", for a pharmaceutical company are still something to be handled with the right fear, developing better ones requires a lot of attention