Nick, you explain things very well. First a comment - one of the supplements listed was AREDS 2 (Age Related Eye Disease Study 2). That's odd because it contains no Omega 3. I have a bottle in front of me and the ingredients are Vitamin C, Vitamin E, Lutein, and Zeaxanthin. There is another version with Zinc but not the one I'm using (VITEYES AREDS 2 ZINC FREE) does not.. Now a question - have you looked at tetra-cis-lycopene? I'm struck by the similarity in structure to lipids, and lycopene has both cis and trans forms. If you have looked at it, I'd be interested to hear your thoughts.
@@1truemoose PUFAs showed benefits to AMD in AREDS 1: www.ncbi.nlm.nih.gov/pmc/articles/PMC7526619/#:~:text=(AREDS) And after AREDS 2 many supp producers started to combine ingredients from both studies, adding more or removing components, to their thinking/liking. Some of them stay meticulous in their study references while others loosly mention only AREDS 2 as most recent.
Doesn't Omega 3 Acid Ethyl Esters contain EPA and DHA omega 3 molecules? Whats the difference between that and "Ethyl Esters" that's been separately counted in these studies?
I’m just going to keep saying it bc i don’t think I can emphasize enough how grateful I am to have access to such high levels of analysis rigour, respect for scientific integrity, and straight up human decency. I know it probably costs you to not pander to all the wobbly unreliable wellness influencers with massive followings. And maybe you’ll have to someday. But I’m just thankful that right here right now you don’t and I can just learn without having to be hypervigilant to garbage information, confirmation bias, and misogyny. Massive thanks and respect to you, Dr. Nic.
@@Physionicthat’s beyond impressive. I’m taking note. I have my own content streams and it really helps to know it can be done without giving in to shoddy sponsors and influencers.
It's been a while and I noticed you have grown from 50k to nearly 200k subscribers. Congrats ❤ You show that unlike influencers that spread misinformation like a plaque. The real experts are still cool headed and data oriented, a stark difference to the chaotic profit driven supplement sales pitches
I love how you bring the mechanistic science and knowledge into how the dynamic processes work and control such a dynamic environment of heart muscles and the blood vessels and flow overtime and how it overtime maintains the “tissue” or vessels… Specially in CVD… but also how it interacts with the immune system and its responses…!! Great “multi-dementional” presentation that gives how intricate and dynamic the systems are … Good job and great talk … Thanks …❤
Please may you consider covering non-traditional training devices like full body vibration plates, ems, blood flow cuffs, sauna, cold exposure, etc! Thank you for this education ❤
Your research is our gain...! What would be interesting is:- The science behind "muscle testing" which can reveal how our bodies react to certain 'substances' (allergic reactions)...
Havent watched it all yet, but a question that keeps poping up for me with the studies on Omega-3 supplements is: How much does the intake of ALA (alpha-linoleic acid) dictate the effect of supplementation and how many of the studies take this in to account? My reasoning is that a high intake of ALA reduces the effect of DHA/EPA supplementation, at least in most individuals where the body can convert ALA to DHA/EPA to some degree. Myself I'm eating mostly plants, (approx 95% plant based by weight, a bit less by calories) but focus on getting plenty of omega 3 from walnuts, hempseeds and ground up chiaseeds, plus some canola oil. I realize theres no simple test to know if one produces enough DHA/EPA, so safest would probably be to take a simple algae supplement, but it's a bit to expensive for my taste...
Dr. Nancy Schneiderman (was on the Today Show years back) said tomato paste is helpful for women for heart and arteries. I have little to back that up. Love your videos.And CONGRATULATIONS !!!!!🎊
my experience: I took fish oil supplements in my 30s, and would get sporadic arrhythmia. I was on a crap diet, but the arrhythmias did cease after stopping the fish oil. Now in my 50s, I've taken a high quality, unfortified cod liver oil, no problems. I eat a lot of salmon, sardines, herring. No problem.
Hi Doc I forced myself a full watch of your video. Its good to know where Omega 3's do not work. I can tell you where Omega 3's work exceptionally well, because they stopped my ever repeating, seemingly non stopping retinal bleedings. As soon i stopped taking it, the bleedings came again.
Fish oil is never going to help when everyone is eating too much readily oxidising PUFAs ( from vegetable oil ) . People mostly have a ratio of 1:25 instead of 1:1-1:4 omega3 / omega6 on a standard American diet .
I've been taking it for years, mainly for immune benefits and as a prophylactic for CVD as I age. Nice to see study results and the actual mechanisms beings affected to back that up, not just hype by vitamin companies! Dr. Nick, PhD, on the job (or maybe Dr. V, PhD - it rhymes - "Dr. V, PhD, makes it easy as 1-2-3").
Ethyl Ester Omega-3 is not the most bioavailable one. Cell membranes are made of phospholipids so more natural Omega-3 are better. See that video and others from Rhonda Patrick: How to Choose a Fish Oil Supplement | Dr. Rhonda Patrick
I agree. Both TG's and Phospholipids are better absorbed than ethyl esters. It might be easier to just increase the dose of the cheaper and more available EE's than to find (and pay more money for) TG's or EE's of Omega3 DHA and EPA.
PLEASE TALK ABOUT C8.....a saturated fat from dairy that has been found to help extend life span possibly and able to replace FISH OIL. please talk about it since you are in the subject of fats. would love your analysis and input.
I have been taking Vital Protein Marine Collagen for 3 years every day. I am young, but have been experiencing constant pain in my joints for the last few years, which no one could figure out. One doctor told me that glutamic acid found in collagen peptides can contribute to the inflammatory response and my body is likely reacting to the peptides. I stopped taking it and I feel better, but did I do damage? One joint has osteoarthritis already. No one has mentioned this!!!!!!!
How was your lipid profile in those 3 years? High cholesterol maybe? Cause omega 3 supplements is said to work for "normal" intake of fats and wont fix a high omega 6 diet, which is mainly saturated fats. On the contrary is counter indicated for people with liver disorder -> insulin resistance cause of the high blood pressure is usually built up in clogged arteries. Without a background of your exams I'd say you symptoms is food sourced (oxalates) and vitamin malabsorption causing calcium depletion from your joins (lack of vit D)
The problem with fish oil is that rancid oil is bad for you and the freshness of these products is questionable by the time you get to the end of the product
I haven't looked hard, but a while back I read a study on oxidized fish oil and it's health effects and they found no effect. If you have other studies showing differently, send them to me please so I can cover it. Thanks, David.
Thank you so much for this analysis of the data, I found it very helpful and eye-opening to boot and also of course thank you so much for pointing out a question I had from way back which is what that fixture was on your wall, which as we now know turned out to be a fire extinguisher / sprinkler!
Another excellent and well researched video! And congratulations on finishing the PhD! I would be interested in hearing about any research that looks at Omega 3 fats in the context of fatty fish consumption. I do not take fish oil supplements, but do consume a lot of salmon and some sardines - I target 2-3g of total EPA+DHA intake per day on average. So it would be interesting if the data shows a difference if the fish oils are eaten through fish instead of by supplement.
So if a study is done where EPA/DHAs are the only variable, then I intuitively don't understand how there can be any conclusive results. I would have a lot more confidence in studies if it was a cohort of vegans, or vegetarians, or ketogenic diets, and EPA/DHA in x dosage was added to their diet.
can you do one on the carnivore diet? because there are so many people say its good and then others are saying it is bad. and I trust your research over there's xo
It's been like that for 1.5 years already. I always answer the question in the title for free and for further information, people are welcome to join the paid platform, if they choose.
Worst case interpretation of static stroke risk : ischemic stroke decreased and stroke from ICH increased. Did they break down the data into stroke types ? It would suck to find out that O3 reduces arterial wall thickness to the point of bleeds.
You mentioned that it increases risk of atrial fibrillation. Did you analyse this study: According to CNN; The study analyzed data on over 415,000 people ages 40 to 69 participating in the UK Biobank, a longitudinal study of the health of people in the United Kingdom. Nearly one-third of those people, who were followed for an average of 12 years, said they regularly used fish oil supplements. For people without heart issues, regular use of fish oil supplements was associated with a 13% higher risk of developing atrial fibrillation and a 5% heightened risk of having a stroke, according to the study, published Tuesday in the journal BMJ Medicine.
I use omega3innovations fish oil. They deliver to home with cold pack. They taste very fresh. I think its the best way to take fish oil to get all the benefits
AFIB side effect leads to increased stroke, hence one plausible explanation for why Omega3's show no net benefit with stroke! Afib is a HUGE risk for thromboembolic stroke. Coumadin give to afib patients may be a big risk for hemorrhagic stroke.
Atrial fibrillation (AFib) is a heart condition that can increase the risk of stroke by three to five times which, given omega-3 increases afib it may be it does not reduce stroke, and could even increase it (which may be why all-cause mortality is no impacted even though CVD is improved).
An analysis of a global data set shows the burden of atrial fibrillation (AF) and atrial flutter (AFL) climbed sharply between 1990 and 2019, with women accounting for much of the increase, and factors such as obesity and alcohol use replacing smoking as key drivers of the disease, according to a study published Wednesday in the Journal of the American Heart Association. So is it the omega 3 or is it obesity n drinking?
Well, these are all intervention trials, so we're creating a cause and effect relationship. As far as I'm aware, there's direct evidence of the effect, but that also doesn't mean there's increased heart disease or heart problems, as noted in the video.
I had A-fib in the form of PVCs for a while, and then they seemed to disappear on their own. I thought I changed nothing in my diet, but I did unintentionally. I stopped eating ground up flax seeds and walnuts. I realize these studies are for fish oil, but it would make sense that by function, they would yield similar side effects.
For PVC's supplementation with magnesium glycinate or citrate may well help. Also stop alcohol to see if that helps. BTW, PVC's are not afib! PVC's are ventricular. Afib is atrial. These have very different prognosis, causes and treatment options.
@@bobw1335 Both are arrhythmia, and PVCs greatly increase the chance of developing Afib. So it isn't out of the ball park to say that Omega 3 supplements may impact having PVCs. But thanks for the magnesium suggestions.
I'm one of those that think Omega3 supplement isn't worth taking after seeing some studies cited by some Omega 3 salesmans. You showed some of them, too I think the evidence is weak, if any there might be a small benefit for cardiovascular health
Sir, first time I'm watching your video. Can u please suggest me appropriate dosage of omega 3 including epa&dha quantity. Not for any medical conditions, just for overall wellbeing Thank you
Wait, it does not reduce all-cause mortality, but it reduces the CVD risk, which is a major killer. So, which other mortality risk does it increase? If one killer is reduced in risk, another one must be increased in risk to keep all cause mortality at zero.
What do you think of C:15 as a "replacement" for Omega-3? I took the bait as the research looked legit, but I do suffer from "wanting to believe" syndrome. It isn't an inexpensive supplement and I am looking for validation; lol. (OR ANY THOUGHTS ON C:15 )
ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-WChLUyT_mUQ.html (I don't know if posting video is allowed?) but he shows some comparisions I am quite interested in understanding better.
Thank you doc, i´ve a pretty naive problem, then the youtube experts 🙂are telling us since 3-5 yrs to take 2 gr. of Omega3, it means in 2010, 2012, or a bit later just few poeple had taken up to 2 gr. Omega 3. If im right,, it is necessary to make in 10 yrs again an anlysis with only studies with 2 gr. ? Thanks a lot
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