Does Glycine extend Lifespan? [Study 297 Study Analysis]

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0:00 - Introduction
00:45 - Topics Covered
01:50 - Mechanism of Action
11:39 - Glycine and Life Extension
11:51 - Study 297
12:23 - Study Design
19:10 - Glycine and Lifespan Data [How to Read the Data]
26:59 - Mid-Point Conclusions
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#glycine #longevity

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3 авг 2024

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Комментарии : 257

@Physionic Месяц назад

No Amendments, currently.

@szlagtrafi9115 Месяц назад

Why does glycine make me extremely sleepy? Same goes for magnesium, taurine, niacin, pregabaline - all these (incl. glycine) have something to do with GABA receptor so this may be the culprit but how do I counteract this sleepiness. That is the question.

@Physionic Месяц назад

Glycine is used for sleep. :)

@szlagtrafi9115 Месяц назад

@@Physionic Exactly, but the extent at which it causes me sleepiness is bothersome. That makes using glycine simply impossible for me. There must be something messed up in my brain...

@midevo_ Месяц назад

@@szlagtrafi9115I actually have a relatable situation whenever I drink coffee but not with caffeine supplements. I was wondering why but did not find a solution as of yet.

@PollyAmorous Месяц назад

@@szlagtrafi9115Take at bedtime.

@pohaa Месяц назад

Best bio-med videos on RU-vid. Hands down. This guy could have a series on TV. It would be awesome!

@jaytm2574 Месяц назад

Taking NAC and TMG daily and I've noticed my physical resiliency has gone up remarkably.

@HisCoconutGun Месяц назад

I've been taking 30g glycine per day for 5 years for a sleep condition. Havent had any side effects except occasional upset stomach. I am a healthcare provider and have extensive bloodwork frequently including ammonia levels as I've read some studies that high doses of glycine may raise ammonia levels. Liver, kidneys, cardio panel all good. Im in my late 20s so life expectancy benefit TBD. Just sharing my experience. Thanks as always, Nicholas.

@unou12die Месяц назад

Just a Google search shows no side effects up to 80-90g a day, and glycine is stomach protective it's NAC that can give stomach aches and your in your 20s so I doubt you take NAC. Although glycine can lower blood pressure (works like an antioxidant) and does have a few weird effects in high doses like odd dreams and lowering body temp(can help with sleep) slightly

@aurapopescu1875 Месяц назад

Why such a high dose? Did you try a lower dose and it didn't work? I am also interested in Glycine for sleep.

@HisCoconutGun Месяц назад

@@aurapopescu1875 I have a severe sleep condition. For most people 1-3g is enough to see improvements in sleep.

@larsnystrom6698 25 дней назад

I supplement with at least 10 g of glycine a day. But also with 4 g of creatine, and that takes away some of the demand for glycine. I also supplement with maybe 12 g of hydrolyzed collagen. The idea is to supply the rest of the amino acids the body needs to build its own collagen. All the 27 or so different kinds of it 🙂 Well, I supplement with more things than that, but the rest isn't glycine-related 🙂

@aurapopescu1875 25 дней назад

@@larsnystrom6698 Does the glycine help with sleep?

@roqclimber Месяц назад

Gly NAC is still a good bet. I've been taking NAC for asthma and osteoarthritis for over a decade. Last year I added TMG. With my other supplements, I'll live forever!

@MochaZilla Месяц назад

Nice! Do Not Age brand?

@EhurtAfy Месяц назад

Just making sure, you do have your aerobic, resistance training, and sleep on point as well right? A lot of people take supplements but don't exercise or have their diet and sleep in order

@larsnystrom6698 Месяц назад

Glycine is the first limiting amino acid for our production of glutathion, L-cysteine is the next one. So GlyNAC is good for us. But the research saying so utilized 100 mg/kg bodyweight of each. A capsule of GlyNAC, what is it 600 mg? Wouldn't do much, would it? My advice is take glycine as a powder. Use it as the only healty sweetener there is. And then take NAC in capsules, because it tastes badly. Or even take L-cysteine (Thorne sells that), or both that and NAC. NAC has an anti-mucus effect. Might be good for the lungs, but is too much of it good for the intestines?

@chriseneim1 Месяц назад

Mac should not be taken for long periods. It is good for short term benefits, but if you look into the studies, you can actually have downsides from NAC in the long run if taken long-term, it happened to me I felt great for a while then all of a sudden out of nowhere after about a year of taking it I woke up with morning and was wheezing and could barely get a breath And that would last for 20 minutes or so first thing in the morning it was so scary so I went to the doctors. He asked me if I’ve been taking anything. I told him yea nac he said it can cause an allergic reaction to to show show up if taking long-term and it’s an asthmatic condition. I don’t have asthma ever in my life. It was so scary for a few weeks. It was doing that. I literally was so scared so I stopped taking it and about a week later all the symptoms of the asthmatic fits disappeared. Plus, glutathione is good when your levels are in balance too much of it can be a bad thing and if you have undiagnosed cancer somewhere, it can be a really bad thing just my experience. But pure glycerin powder has been an absolute godsend, or a single side effect, only benefits I have never found a supplement or a amino acid that does the job that glycine on its own does.

@michael-qp9xd Месяц назад

Hello - i too started on glynac so taking about 3 grams gly and 3 grams nac. But then saw that nac has a side effect of cartilage and joint breakdown in some. But many other benefits as u mention. But to be safe now back way down on nac so at maybe now 0.5 grams. Don’t want to risk any joint damage as maybe not to notice till after much breakdown. This just an fyi as maybe not this bad effect for all.

@davefit-areyousaturated9830 Месяц назад

I started taking about 9g of glycine a day divided into 3 servings of 3g, At night I take 3g with NAC before bed. I’ve noticed a significant improvement in my skin, face is smoother, firmer etc. I started taking based on age loss of glycine and for joint improvement etc, but the noticeable skin improvement was a nice bonus. I knew it was good for the skin just didn’t expect to see those results so quickly.

@rajanganger5942 Месяц назад

I take all in powder form in water as follows, NAC 2 grams, Glycine 3 grams (plus in coffee so total 12+ grams, Taurine 5 grams and MSM 3 grams.

@miracoli16 Месяц назад

How long did it take to see/feel improvements?

@davefit-areyousaturated9830 Месяц назад

@@miracoli16 I noticed a difference in my skin in just a couple days, and it kept improving for another several days, then just maintained

@aurapopescu1875 Месяц назад

9 grams is a lot! Did you see any improvement in your sleep?

@rajanganger5942 Месяц назад

@@aurapopescu1875 I sleep like a baby even before taking supplements. But now I struggle to get up in the morning, I can sleep for 12 hours even before taking glycine (caffeine has no waking effect on me).

@ilevitatecs2 Месяц назад

There are too many well designed studies on glycine to review for a variety of end-points-including its role as a secretagogue of GLP-1…which is entirely a separate mechanism from others including scar tissue repair/development, motor function, systemic inflammation, collagen synthesis, glutathione production…it’s such safe bet to take exogenously with low hazard ratios that one of the mechanisms will benefit longevity more than relying on endogenous production.

@movewithmike Месяц назад

Thanks again for your approach to sharing these research studies. You arent like many RU-vidrs who hype results to get likes. You are doing a great service to science snd your fans by making these clear videos! Thank you and may you live long (and prosper).

@Physionic Месяц назад

Thanks, Mike. My main priority is being realistic (but still fascinated) by the science. Plus, people lose trust in you if you just hype everything just for the sake of it.

@chriseneim1 Месяц назад

I take 5 g of glycine before bed every night I have been for the last year. I work all day in the sun. I’m extremely exhausted. My body should be absolutely torn up every day, but let me tell you. I may only get four hours of sleep, but I have never felt better since I started taking glycine I sleep so good. It’s almost like it’s too good to be true because as soon as I stop taking it just to see if it is actually the glycine that’s making me feel good. I get really exhausted the next day after a long day at work and my body aches. I have taken NAC before for long periods of time, but my current regime is a gram of calm, magnesium citrate 5 g of pure glycerin from now company straight in the mouth. It’s sweet it taste good and then a gram of Ttaurine crystals powder in hot water with the magnesium I have never felt so amazing. And I do those sleep apps where it listens. If you snore, I used to snore and talk like crazy ever since I started my glycine regime I get maybe five minutes of snoring in a whole entire night when prior it was like an hour and a half to two hours. Like I said I get four hours of sleep some nights and wake up feeling like I got 10 the stuff is amazing. It’s so amazing.

@shaunanorman4804 Месяц назад

What are the crystals you take ?

@Beans-great Месяц назад

I’ve been taking 6 grams of taurine for the past two weeks and am noticing some improvements in energy, strength, sleep, and skin health. All anecdotal but definitely noteworthy.

@nicolatesla5786 Месяц назад

Who sells them ?

@astonuk9403 Месяц назад

siim land joined the chat.

@ConnieWobbles Месяц назад

😂

@geladaizlabon3605 Месяц назад

😂 they should collab 😂

@larsnystrom6698 Месяц назад

Slim Land and Dr diNicolantonio's book about Collagen seems to align with the research paper: A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis ENRIQUE MELÉNDEZ-HEVIA1 et al I don't remember if they referenced that paper. But their conclusions certainly does align. At least 10 g more glycine a day to fulfill every need.

@jackbuaer3828 Месяц назад

LOL

@christiancrafoord Месяц назад

@@larsnystrom6698 10 g more, or 10 g baseline. so if i take collagen 10 g, then 33% would be glycine = 3g. then i supplement 6g --> = 9g, then 3 g from diet totalling 12 g? would that be sufficient?

@glenntimberlake2413 Месяц назад

Thank you for talking on these subjects. Most appreciated.!

@charleshartlen3914 Месяц назад

instant sub for this level of content. thanks a lot for this and in the future ill be considering your insider group!

@RchamTV Месяц назад

Donghua Jinlong industrial glycine

@Dan-dg9pi Месяц назад

By sheer coincidence, just yesterday I was discussing Prolegomena to any Future Metaphysics with my pet mouse. He thought Kant's analysis suffered because he completely ignored the topic of cheese.

@larsnystrom6698 Месяц назад

It's a myth that mice like cheese! My mouse friend told me that they eat anything, even cheese. Although they prefer to be herbivores. They just hate keto!

@Physionic Месяц назад

😂

@13thbiosphere 22 дня назад

glycine can help limit the damage caused by reactive oxygen species (ROS). Glycine is a simple amino acid that has several roles in the body, including acting as an antioxidant. Here are some ways glycine can contribute to reducing oxidative stress: Glutathione Synthesis: Glycine is a precursor for glutathione, one of the most important antioxidants in the body. Glutathione neutralizes ROS and protects cells from oxidative damage. Anti-inflammatory Properties: Glycine has anti-inflammatory effects, which can help reduce inflammation-induced oxidative stress. Membrane Stabilization: Glycine can help stabilize cell membranes, making them less susceptible to oxidative damage. Inhibition of ROS Production: Glycine can inhibit the production of ROS in certain cellular pathways, thereby reducing oxidative stress. Cytoprotective Effects: Glycine has cytoprotective effects, meaning it helps protect cells from various types of damage, including oxidative damage.

@christianlamb2276 Месяц назад

Thanks, Doc, for what you do 😊

@richardtibbetts574 Месяц назад

I take half of my daily dose of glycine in my bulletproof coffee. It makes the drink sweet, without the negative effects of sugar or artificial sweeteners.

@jamesalles139 Месяц назад

thanks for the post I am starting on Glycine + NAC

@husseintammam4691 Месяц назад

Haven't watched the video yet, but sooo excited to see this. I'm really interested in glycine and red light therapy. I sent you a big comment on your older collagen video about glycine where I asking if the benefits of collagen supplementation could instead be to due to glycine rather than the specific collagen peptides. Do they have distinct benefits? I don't know if you address that here, I'll watch the video and edit this comment if so lol, but I think I'll definitely be joining your insider's community soon. I'm in love with your content man. its so awesome what you're doing. I'm so tired of all the youtube researchers with blatant agendas/extreme confirmation bias whether that's keto, high carb, vegan, carnivore, obsessive contrarians that are against any conventional medicine or peeps that just tryna prove that anything new or alternative is dumb. I also love that you're very careful about what conclusions we can draw from the evidence and just accepting that sometimes we just need more research, I think that's often the answer to a lot of issues.

@joen.8364 Месяц назад

Thank you for addressing this sir!! I just provided links below for anyone that wanted to see some data.

@saralakushwaha1180 Месяц назад

Thank You

@christianlamb2276 Месяц назад

Your videos have sparked my interest in free-form amino acids 😊

@yeahnahyeahnahprivateacc 8 дней назад

Underrated channel.

@oibal60 24 дня назад

Thanks again.

@overandoverandover56 Месяц назад

I was taking glycine at about 3 grams per day. Rat studies suggest glycine increases bleeding time and this has been my experience leading to systs that had to be lanced and took weeks longer to heal than expected. Be very careful with glycine if you have any bleeding risks

@terminator3728 Месяц назад

Take 4-5 g a day never experience this or heard anything about it

@larsnystrom6698 25 дней назад

I was surprised by this, so I googled it Glycine reduces platelet aggregation Peter Schemmer et al Surprised that there were some truth in it. I myself haven't noticed anything like that from supplementing with at least 10 g a day for a long time. But healing wouldn't slow down by that. I would guess reduced collagen production could be the culprit. Glycine or collagen should help with that, not hinder it. Copper and vitamin C is also needed for that to work properly. By the way, less sticky blood platelets is something many actually want. Less problems with blood clots, one would think.

@Borkgrooming Месяц назад

APPRECIATE YOU BRO

@joeblair774 Месяц назад

Thank you, next time please mention how to join your course please maybe at the end of your video but anyway you are the most informative RU-vidr I watch and i greatly appreciate the time & effort you put into your videos much luv and respect

@whitewolf6730 Месяц назад

Well, I’ll be darned. I just took it for sleep. I am a non paying member of your community. Maybe one day I’ll upgrade. I really appreciate the way you tackle things and show great easy to read charts and data to support what you are communicating. I do have a Science background however. My wife or my brothers might get lost in some of this, but I appreciate it a lot.

@aurapopescu1875 Месяц назад

How much do you take for sleep?

@Mind69420 28 дней назад

Glycine is one of my favorite supplements for sleep quality. I've always had issues falling asleep but glycine helps me unwind enough to go to sleep if I try.

@bobbyventon5015 Месяц назад

Your mentioning of pro-inflammatory molecules and immune cells inspired me to dare to ask you a question. Have you ever run into studies analyzing how metabolic health is correlated with allergies? I know I'm just an n of 1 but I'm simply flabbergasted that this season my hay fever responded to treatment tremendously well and over the past 15 years the response was just a minor improvement. The variables that have changed the most are that I lost a lot of excess fat last summer and have been exercising quite regularly since then (i.e. I've built some muscle). Sleep quality has improved a lot as well. Another crazy side effect is that - again, after 15 years - I no longer experience hangovers (I used to get them after literally one beer). I'm obviously very happy with my improved health but I also wonder - is it mere coincidence or is there research linking metabolic health to such things, especially allergies. If this is a question you'd be happy to investigate if only I were a Physionic insider, state so bluntly! 😅

@Physionic Месяц назад

I haven't looked into it, but I know that immune cells become more or less inflammatory/activated based on their metabolism. They tend to become more active when they use glycolysis (carbohydrate metabolism) and less so when using fatty acids - there's some nuance there, but it's generally true. I suppose that might affect allergies if it applies to cells like granulocytes. I do focus my attention on what the Insiders want me to cover, mainly because I receive at least 50 requests a day and as I'm one person, it's impossible for me to meet that demand.

@bobbyventon5015 Месяц назад

@@Physionic Thank you so much for the response! I'll try to digest it when I have a few spare minutes and if I'm hungry for more I'll surely join those 50+ crowd 😁.

@fishnski9211 Месяц назад

Ive gone down the rabbit hole of longevity supplements but we all have to be careful in our doses..more is not better at this point imo...there will come a time maybe by AI a formula that gives proper doses that don't tip the balance one way or another...im thinking that lower doses until further notice would be the prudent approach...

@nimblegoat Месяц назад

eating well, exercise , keep moving , keep doing. Is the most simplest and is all 100% proven. My take is keep supplements to minimum and well proven , that have little or no downsides, unless you are taking bloods/tests to see doesn't affect you

@samuraibat1916 Месяц назад

New Physionic video let's GOOOOO

@jackbuaer3828 Месяц назад

LOL at the enthusiasm for a Nutrition video. That was not meant in a negative way in any manner. It's just not something that is typically seen. That's why it's funny to me.

@samuraibat1916 Месяц назад

@@jackbuaer3828 LOL. I appreciate it. I'm so tired today my levels of excitement are all over the place so I probably seem pretty goofy.

@hafidzy9675 11 дней назад

I take 5 gram glycine total 15g per day after breakfast ,lunch ,diner help with digstion , blood sugar and also help with skin 👍

@el-artista-marginado Месяц назад

much much prospèrity for you is my course on you. keep it cool

@Physionic Месяц назад

Thank you! Likewise.

@edvedder7835 Месяц назад

Great content. Much appreciated! I've been combining Glycine/NAC on and off for the pass 4 years, boosting gluthiaone. Glycine helps for sleep. Kumar at BSW from Texas had a very compelling paper. Could you consider Rapamycin/Sirolimus as an upcoming content video? Thanks.

@nattydred2593 Месяц назад

Cool. Thanks. BTW The Michigan make effect was not statistically significant, so it was a single site benefit.

@Holy.HannaH Месяц назад

14:36 well I feel called out🤷‍♀️🤣 where are these humans that understand me & Kant better than animals do? At this point Im finding it interesting that all of these molecules/supplements I utilized to keep myself alive are being looked into for longevity in general. I chose them each for their specific methods of action in accordance with what was transpiring in my body/brain at any given time. Barring any specific formula for the specific amount of amino acids our body needs(Ive not ruled this out), from my constant experience Im thinking longevity comes not from a single molecule but from providing your body with what it needs, when it needs it. Not going to the doc every so often and trying different things for weeks or momths at a time. Which requires knowledge & understanding of one's own body as well as the capacity to search, find, and interpret all the data. I highly applaud you for teaching folks how to do that.

@user-jq8yr8oi3s Месяц назад

A video about bromelin , please !!!!

@treesoul00 Месяц назад

That’s frustrating about the location specific data changing so much. Why. If they’re from the same source and use the same nutrition. Is it air, water, circadian rhythm, interaction with the humans. Omg so many factors. Just basically nullifies the whole study imo if the effects are so inconsistent. All I’m getting from this is which lab I’d want to go to as a mouse.

@MrXharbour Месяц назад

If glycine blocks methionine from triggering mTor, then should it be avoided after resistance training for a few hours (or more)?

@charlesfuchs Месяц назад

Nope, you will get ripped

@incognitotorpedo42 Месяц назад

If that mechanism is a strong enough effect, and if mTor activation by Met is sufficiently important in exercise-driven hypertrophy, then yeah. Without knowing either of these, I'd say go ahead and avoid Gly after workouts (for the next 12 hours for example). That's not a big deal unless you are working out a lot more often than I do.

@frankenz66 Месяц назад

I have been "doing" 3 grm of glycine and 3 grms of NAC daily. Seems pretty nice. I can tell if I go without a few days. Which I do to not let my body get accustomed to "needing" anything. Of course I do meat and milk so glycine is supposed to be in there. Thanks!

@jaykraft9523 Месяц назад

same regimen for me for about a year now, nutricost powders of both

@miracoli16 Месяц назад

Meat and milk aren't high in glycine.

@frankenz66 Месяц назад

@@miracoli16 Seeds are the only one category where non carnivore foods have decent amounts of glycine. Meat, fish and dairy are otherwise highest.

@frankenz66 Месяц назад

@@jaykraft9523 I capsule my own powders

@theochris7088 Месяц назад

make a review of PQQ and ERGOTHIONEINE, thank you....

@michael-qp9xd Месяц назад

Thank you for great video. I take glycine twice a day - about 2 grams in morning and dinner time. But maybe not good all time as slows down mtor - this needed on days using heavy weight exercise for muscle development? Should avoid glycine then over full day - on days doing resistance exercises? Or avoid 2 to 4 hours before and after only? Thanks any ideas.

@thomasmuller1850 Месяц назад

I wish to have studies with very healthy fed mice instead of using the standard chow, so you can see if an intervention adding any benefit above that.

@ivalani Месяц назад

Here’s a fun topic for you to research (and gain thousands of new viewers): Do semaglutide and tirzepatide heal fatty liver?

@ManlioLoGiudice Месяц назад

Great one. I'll reach out to have a podcast session with you! Question in the meantime: glycine interacts with methionine and, according to the study/hypothesis, does remove methionine from the cell. How do you see the action of TMG/betaine here? TMG should "convert" homocysteine into methionine. I understand the goal:TMG should give you more energy and it may be good for muscle (see mTOR) vs longevity. So, if I do take both, shall I alternate or keep separate or else?

@Blurns Месяц назад

Whenever a news article or video is a question, you know the answer is "no".

@SaxonNinja Месяц назад

This is really interesting and I'm wondering if you've already done a video on the statistical benefits of creatine supplementation? According to what I've read, creatine consists of the combination of Arginine, Glycine, and Methyonine.... so it seems according to what you've said that it would be a great way to assimilate more Glycine in the body?

@jenn1663 Месяц назад

He's done multiple videos on creatine along with a book you can download

@glenntimberlake2413 Месяц назад

That brings up a good point. Or points. I would really like to see a talk that explains where we get Glycine in our diets and in other supplements. How much useful glycine do I actually get when I take Drs. Best Mg Glycinate? (Based on various dosing.) Which food sources have the most Glycine? Is Glycine from these various sources readily taken up and utilized as Glycine in the body? How much Glycine is really necessary for us to get desired results? Do we need to take it before food or is it well absorbed after consuming a meal? - which may be easier on gut “happiness” and keeps a person from tanking up on unsweetened tea (a way to consume sickeningly sweet Glycine) and being to full to eat food. Just honest questions that I believe a lot of people need to know the answers to. And how did my many months of miserable knee pain significantly reduce after adding in Glycine only about a week or less after adding it to the NAC and supplements I was already taking.? NAC and the other supplements combined didn’t do it. It took the addition of Glycine.. (I also take a couple scoops of Creating and a scoop or two of L-Glutamine most days.) (nd for a few weeks I have been taking 3000 mg Ashwegandha at night with hopes to help sleep and lower inflammation and pain issues.)

@Discostick55 Месяц назад

Interesting. Gonna have to finish watching the full video but I'm reminded of a few years ago there was a 'scandal' in whey powders that they were 'spiked' with glycine or taurine. Funnily enough maybe if these appear to be beneficial, that could actually be something you want?

@Physionic Месяц назад

Interesting, I never heard of that. I remember preworkout powders being spiked with meth like molecules at one point.

@tequila_baby Месяц назад

The muscle preservation/growth glicine effect maybe is the reason.

@anymouse6202 Месяц назад

Thanks

@devlogicg2875 Месяц назад

Thanks Doctor. Is the new UTexas study relating to telomerase reverse transcriptase (TERT) valid in your opinion?

@squeakypistonproductions2228 Месяц назад

Can you do a video on plasmalogens and plasmalogen precursors?

@Beld77 Месяц назад

@physionic can you do a deep dive into molecular Hydrogen and its potential benefits? Whether it be dissolved hydrogen water or hydrogen gas delivery? Lot of promising evidence, but seems too good to be true and would love your take!

@alansnyder8448 Месяц назад

I'm confused by this request and hope it is a joke. H2 would be a gas and wouldn't stay around in a person very long. Could you mean something else by that?

@10khillred Месяц назад

Just coincidental, I started taking Glycine few days ago, 1 to 3g per day, I noticed increased energy level with dry mouth. This is the only supplement I added. I was taking Taurine without much feelings which I stopped. The only other supplement I got a strong feeling is Creatine but only for the first time.

@excalibur7185 Месяц назад

Do a piece on allulose.

@littlevoice_11 Месяц назад

Regarding gly-NAC, would the benefits of this combination be achieved through collagen 20G (presumably high in glycine) with NAC?

@averylweaver Месяц назад

Hi, Nick! Have you come across any studies on nicotine's effects on oral health? I'm really curious about the effect specifically of gum/pouch/lozenge on oral mucosa (vasoconstrictor is all I've heard). Thanks!

@photo200 Месяц назад

Great video! Question: It appears that if the reduction in mTOR activity is the driver of the benefits, that depends on glycine being able to accept methyl groups from methionine. If that's the case, would this benefit potentially not accrue to additional consumption of glycine which is already methylated, such as TMG?

@TekMoliGy Месяц назад

so does methionine and mtor increase muscle growth and then glycine would inhibit mtor and muscle growth for bodybuilding?

@christianlamb2276 Месяц назад

I have been taking combinations of free-form amino acids.I have found that threonine,theanine,methionine taurine, and glutamine together along with b6 b9 b12 and betain has a very nice effect along with other combinations free form amino acids are wear it's at.do your research on each one you will discover amazing things.

@Joe_C. Месяц назад

What 'effects' are these that you describe as "very nice"??

@jjperry3995 Месяц назад

I cannot take straight Glycine but do take TMG (Trimethylglycine) due to a genetic issue.

@sergey9986 Месяц назад

If the explanation is correct, TMG (trimethylglycine) should decrease lifespan. It is quite a popular supplement though. Are there any studies on that?

@glendaguilott3765 Месяц назад

Do you know of any studies for natural cures for vertebral stenosis ???

@anatolydyatlov963 Месяц назад

Oh wow, that lens makes you look even younger!

@Physionic Месяц назад

What lens?

@Maxim.Teleguz Месяц назад

@@Physionicglasses or new camera lens.

@Maxim.Teleguz Месяц назад

@@Physioniccan you do a study on amphetamines over long term.

@anatolydyatlov963 Месяц назад

@@Physionic The camera - it's different than the one you usually use. For example, your skin looks much brighter

@unou12die Месяц назад

@@Maxim.Teleguzif your lifespan is a candle just light both ends. That's what happens over time you age faster and die younger but look very old

@rlittlefield2691 Месяц назад

I seem to be allergic to glycine . I did not realize this w hen I heard it would stop the aging process, In my case if I kept using it, it would have killed me and so would have stopped the aging process.

@wasmagpie Месяц назад

GLycine completely destroys my gut for days, even in small doses

@eelcohoogendoorn8044 Месяц назад

Yeah it has a bunch of mild but annoying side effects on me. 3g a day seems fine but I prefer to get most of mine from diet.

@geladaizlabon3605 Месяц назад

I been using glycine for months 5-10 gm so far i only see positive. Look younger than my twin

@larsnystrom6698 Месяц назад

Try it as a sweetener for natural, unsweetened whey. It's not really natural to eat single amino acids. Some people complain about a brain effect. So it's wise to test with a small dose and see if you are one of those. Most people notice nothing, though. Glycine is just food for most of us. Glycine is an inhibitory neurotransmitter in the central nervous system, especially in the spinal cord, brainstem, and retina.

@smarzig Месяц назад

@@geladaizlabon3605dose?

@TheKoPro11 Месяц назад

You probably have low stomach acid then. If the protein is not digested properly in the stomach there will be issues when the protein sits in the gut. It could be worth a try to consume the glycine with acidic beverages like coffee or juice.

@debmanrique6466 Месяц назад

I'm not too concerned about the contraindications for cancer patients- cancer thrives on almost everything we eat.

@chazwyman Месяц назад

I wonder if the positive benefit is not about glycine per se, but the simple fact that the glycine fed mice benefit from having an extra bit of protein in their diet. and that this effect could be repeated for any amino acid and not just glcyine. Just a suggestion. Maybe having more protein in the diet causing better satiation, might improve the prospects of mice. It would depend on understanding if the mice are allowed to free browse on food, or if they are calorie and macro measured.????

@jeffg4686 Месяц назад

high protein only when wanting to put on muscle. Otherwise, 1 cup of lentils likely enough for the day.

@Alex-yo7sr Месяц назад

Nick, we often see that these compounds that reduce inflammation and cell divisision/creation increase lifespan Is it possible that inflammation in general and creation of cells cause aging, meaning exercise (which causes both) could be seen as unhealthy?

@SilverFan21k Месяц назад

Based.

@larsnystrom6698 25 дней назад

I didn't know that methionine activated mTOR. And if I did, I wouldn't expect glycine to reduce that effect. I belived that the negative effect of too much methionine without enough of glycine was that it increased the homocysteine level. Although, I haven't seen anyone really show that. But what I've been able to guess about it is: 1 ■ Protein restriction increases lifespan. 2 ■ It wasn't really protein restriction but methionine restriction that did it! 3 ■ it wasn't really too much methionine but too little glycine that did it! That was what I got from a sequence of research articles that didn't really combine those conclusions. Too much methionine can increase the homocysteine level, and that's not good. But is that all? I guess that's for a real scientist to find out, eventually. Meanwhile, I supplement with 10 g of glycine a day.

@DEValentine Месяц назад

What dosage of glycine is recommended for adult human males?

@charlesfuchs Месяц назад

Glycine changed my life!

@TheBroSplit Месяц назад

How so? Dose?

@charlesfuchs Месяц назад

@@TheBroSplit 10 Grams min

@dbzwarrior4321 Месяц назад

What did it do? Make you look younger?

@unou12die Месяц назад

It's can be used as a sweetener, it's 1.5 times sweeter then sugar. That's why I was interested in it at first and I used a lot more daily. Glycine is in collagen, bone marrow, glutathione. It is a life changer as a sweetener or just a supplement and a sleep aid. Easy to add to your routine

@TheBroSplit Месяц назад

@@charlesfuchs benefits? Changed your life how?

@jaykraft9523 Месяц назад

Looks like you're analyzing a somewhat old 2019 ITP study (you seemed to disclose less about the study as usual), with unexceptional results (e.g. 4% lifespan increase), whereas the Baylor results on GLYNAC (Glycine + NAC) are way more exciting (over 20% lifespan extension). What would be REALLY nice is for another center to study GLYNAC besides Baylor since nearly all GLYNAC results have been from the same center (Baylor).

@Physionic Месяц назад

It's the only glycine ITP study I know, so the age of the study shouldn't matter. I've covered the GlyNAC Baylor studies at length, so there's no reason for me to cover them here, as well. One thing at a time, otherwise things get confusing.

@keithbyrd7566 Месяц назад

Why do you choose to be condescending in your comment? What value does that tone add to the quality of the discussion?

@werundwarum Месяц назад

@@keithbyrd7566who hurt your feelings? There’s absolutely no tone whatsoever in his comment?!

@jaykraft9523 Месяц назад

@@werundwarum correct!! critical maybe, condescending no.

@jayalanlife5926 Месяц назад

Ok my opinion is that Nic is one of the softest, nonconfrontational, high quality RU-vidrs around, if you find his humor not to your liking find someone better and go

@minemilx2702 Месяц назад

Hi, without watching the video yet I just want to bring up glynac and tbe possibility of it being cancer promoting? If it is adressed in the video then don't answer if not, you would be an angel to adress it 😍. I'll become a patreon (probably will anyways).

@matttee1319 Месяц назад

Ha!

@Physionic Месяц назад

Google asked if I wanted this translated to English. I do.

@christianlamb2276 Месяц назад

My comment cut out zink ,very important also in these combinations

@MadLadsAnonymous Месяц назад

What about TMG+NACET? And if we're going with glycine, add some collagen with Vit C, right? So.. TMG+NACET+collagen+C

@itzikca Месяц назад

Will glycine inhibit muscle growth then?

@wstockall Месяц назад

So does this study indicate that glycine supplementation increases lifespan in mice, or that standard mouse chow is deficient in glycine?

@yummymealsss Месяц назад

One and big question, can we get enough Glycine with diet? Spend money on supplements because of mouse data show that can extend lifespan not best option. It would be cool if you in video, put some foods rich glycine or other stuff that people can think it is worth or not. I would like to watch TOP 5 Amino acid that really worth to buy which will extend your lifespan. Thanks

@betzib8021 Месяц назад

But if you have high cell division....wouldn't you reach Hayflick limit sooner and end up with more senescent cells? And wouldn't this accelerate the aging process for anyone....a process that even young, healthy people do not want?

@maestroharmony343 Месяц назад

I still wonder how much NAC to take. Took 3600 mg a day for almost 6 months, but blood levels of glutathione didn't change significantly before and after.

@bradleyrm Месяц назад

You must it in combination with Glycine.

@maestroharmony343 Месяц назад

@@bradleyrmI do, it doesn't move the needle.

@jdavidmorris7853 Месяц назад

I take Magnesium Glycinate. Any relevance? Is it a source of glycine?

@aurapopescu1875 Месяц назад

Good question.

@jimdandy8996 Месяц назад

What about TMG?

@ancesthntr 25 дней назад

Will TMG give similar results to pure glycine with no methyl groups?

@MrDjhealth Месяц назад

When it comes to Studies is it possible to have very old obscure studies that have been forgotten about in our current time and shelved collecting dust somewhere ?

@Physionic Месяц назад

Mm.. maybe a few, but they're all scanned and collected into the medicine library PubMed - you'll find studies there from as far back as the 1920s and beyond.

@TheSmiaf Месяц назад

Need to ask this probably stupid question.... Asking with a lot of these micronutrients subjects if they help with expanding our lifespan. Could you not ask the same about water or vitamin C? Or is it not that obvious with the last two? So in this case glycine you can find in meats, fish, seeds...

@dbzwarrior4321 Месяц назад

Guys im 28 years old and i want to try glycine should i also add nac? Also where can i buy theese products safely and what mlg should i take for both?

@dbzwarrior4321 Месяц назад

@_zantetsuken_ so should I just take glycine with collegan peptides? I'm trying perseve my youthful skin and body what amount should I take

@ericalewis9047 Месяц назад

Im curious though, is there not enough glycine in rat chow? A normal person would be eating it in their food and supplementing to get extra. Maybe as long as we have it we live longer than those that dont have it but would supplements making us have extra still cause us to live longer? I used to have rats and i remember thinking their food was just enough to keep them alive, but not great. I also wondered if it wasnt their food causing tumors. I am not sure im saying this clear. I just wonder if its actually showing added glycine helps or having it at all helps, since who knows how trust worthy rat/mouse food is.

@1969spp Месяц назад

I'm ok with mice studies as long as we account for chrono-biological differences.

@1969spp Месяц назад

Any other labs replicating that GlyNac study?

@richardcottone6620 Месяц назад

except for the mouse in The Green Mile

@betzib8021 Месяц назад

And then you have to know Stephen King.

@lawdogwales5921 Месяц назад

Mr Jingles!

@Soundmind68 Месяц назад

I need me some Donghua Jinlong Industrial Glycine

@33Crazydude Месяц назад

Glycine is good for skin youthfulness I hear

@larsnystrom6698 Месяц назад

Good for collagen production, so yes good for the skin, tendons, ligaments, bone, joints, blood vessels, intestines, and just about everything. There's a lot of collagen in our bodies, and it ages, and has to be replaced. If that's done too slowly we become stiff and wrinkled! The best way is to eat 10 -12 g of hydrolyzed collagen for this. Then you get some glycine (3 g or so), but also the other amino acids needed to build your own 27 or so differnt kinds of collagen. In addition to that, you need glycine for other things too. You would have to eat a lot of collagen to get enough of that. So, I think supplementing also with glycine is very sensible.

@33Crazydude Месяц назад

@@larsnystrom6698 thank you 👍

@johnrdadrian Месяц назад

Mr Physionic, I love the topic, and would love to find out what the answer is. But have you listened to yourself. I want to find out if Glycine Extends Lifespan. I'm also interested in negative and positive effects. I'm not interested if a Mouse has Blue Eyes, or where labs get their mice. You talk and talk and talk, waiting for relevant information is too painful. I'll have to search elsewhere. I humbly suggest you focus of the topic, and provide relevant information efficiently.