Fatty Acid Synthesis Pathway: Overview, Enzymes and Regulation

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Fatty Acid Synthesis Pathway Lesson: Where it happens, how it happens and why it happens.
Hey everyone! In this lesson you will learn about the fatty acid synthesis pathway, including an in-depth overview of the pathway, where fatty acid synthesis occurs in the body, what is required for fatty acid synthesis, the enzymes involved in the pathway and how the fatty acid synthase complex utilizes a cyclical reaction process to extend the fatty acyl chain of a synthesizing fatty acid.
I am always looking for advice on how to improve my videos - any and all help would be greatly appreciated :) And as always, if you need help with any concepts, please don't hesitate to ask - I'll try my best to help you :)
Please smash the like button if you liked the video, and subscribe and click the notification bell to help support the channel and stay up-to-date on future lessons!
JJ
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
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Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ

Опубликовано:

9 окт 2017

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Комментарии : 87

@michallyson8922 3 года назад

Just some to clarify some small inaccuracies for some people that may be confused: -Before butyryl-CoA is formed it must undergo the reduction, dehydration and then reduction again whereas here it is shown that as soon as joining of Acetyl moiety to Melonyl-ACP takes place, the butyryl-Coa is formed. -It also stays attached to ACP therefore it should actually be butyryl-ACP. -The 6 carbon fatty acid is also produced on the second cycle not the first. This is a great video tho and it helped me to fathom this process. To those, like me that are learning for undergrad study I recommend using a variety of sources and deeper research in general to help solidify this knowledge and to be able to apply it when answering questions.

@KainCorvin 6 лет назад

Really good explanation. It really helps to connect the dots! I new, for instance, that both malonyl CoA and NADPH were important but not exactly for what. This overview gives you the answer. Perfect for repetition for exams.

@omurukakingsley 2 года назад

thanks JJ Medicine. I've been really finding it difficult to understand the cycling reactions but after watching your video, I just understood. Thanks so much.

@pthuong.0110 2 месяца назад

As I'm cramming for biochemistry final, I'll always start any pathway with your video before reading our book. This condensed content is exactly what I need when my attention span is... limited at best and non-existent at worst. Thank you!

@snlvl 5 лет назад

Thank you so much! A really really good explanation. I see it more clear now!

@khoshalsaidy526 6 лет назад

Finnaly i found, that from where our teacher is learning and teaching fatty acid synthesis😐

@anielkavaleska9123 5 лет назад

😂

@samikshapathania3786 2 года назад

😂😂

@advikdutta 2 года назад

😂😂😂😂

@pctnowin1251 Год назад

You should appreciate if your teacher is putting in effort to make the topic easier for you

@owaniedmond8914 Год назад

Finally understood the difference between hard work and smart work. You are just too smart 🤝

@maxwellsimon4538 Год назад

In highschool biology, we were only ever taught where sugars come from and how they're formed. I always wondered how fatty acids, as well as the other groups of organic molecules were formed, and now I know

@AtaAta-dk8vg 4 года назад

Thank you so much!I study in Turkey and I didn’t understand in the class but I get it now 👍🏻

@ElizabethMadisonnutrition 2 года назад

This was great, simple to understand overview of fatty acid synthesis. Thanks so much!!

@Tehve1 6 лет назад

Thank you so much, God bless!

@osamasyed409 5 лет назад

Fantastic explanation + good visuals!! Thank you!

@ht5381 6 лет назад

Very good video, really appreciate the clear explanation. Thank you !

@katarinala 6 лет назад

Best Biochem teacher! 😙😙😙

@mariediederichs2604 11 месяцев назад

this was the best video I saw on this topic, very precise and comprehensible explanation!

@interestingandinformationcombo Год назад

hats off to u sir g apka lec leny k baad mujhy ye topic sbsy easy lg raha hy

@hirarafiq4970 5 лет назад

Very clear explanation of end product

@map7378 6 лет назад

Best explanation of faty acid biosynthesis

@alevelsdemystified3410 3 года назад

Such an excellent video!

@abdelrahmanrady7995 3 года назад

Keep going!! U're definitely awesome with fantastic diagrams thank you!!

@soemoe5087 5 лет назад

This video is awesome..Thank you!

@bnengin 5 лет назад

amazing! thanks for a million

@iamarpanghosh 2 года назад

This video is very helpful! Thank you!

@SalsabeelAraby Год назад

Extremely helpful and simple. Thank you so much🥰🥰🥰🥰🥰

@goodguy3075 6 лет назад

Amazing 😘😘Love it and really helpful

@seldo7825 Год назад

Perfect explanation ❤

@user-nu7ut8mq7v 3 месяца назад

this is awesome !!!

@logy3481 3 месяца назад

God bless you and your efforts

@hesamb9135 2 года назад

What a wonderful video!

@NehaSingh-tb4vm 3 года назад

great video....will share it with my students...thanks !

@030bhumikadas5 5 лет назад

Thanks..its awesome

@alevelsdemystified3410 3 года назад

a couple of things to add for the sake of elaboration. This palmitate can be elongated. by the addition of 2C units in the SER. Malonyl coA is still the 2C donor and NADPH provides reduction. The brain is special in that it can produce very long chain fatty acids. The resulting fatty acid can be desaturated in the SER by acyl coA desaturases (addition of cis double bonds). This is how unsaturated fatty acids are produced denovo! This process requires, oxygen, NADH, cytochrome b5 and FAD linked reductase. First double bond normally added between the 9th and 10th C atom. The fatty acid synthase has 6 enzymic domains. 1.Condensing enzyme (3-ketoacyl ACP synthase) domain onto which the initial acetyl coA is shifted from its original attachment to ACo domain (a non-enzymic domain) 2.malonyl/acetyl coA-ACP transacylase 3. 3 ketoacyl ACP reductase 4.3 hydroxy acyl ACP dehydratase 5.enoyl ACP reductase

@srikantpanda7993 Год назад

best video thank you

@alifasatyanis7742 6 лет назад

Thanks a lot!

@jasurbektursunov6918 2 года назад

Very understandable 👍.

@anahitarezaei3057 Месяц назад

Thank u so much I was almost crying I have an exam in 2 hours!!!

@mziwabantuyaya9600 3 года назад

Saved a life, you made it straightforward and simple. Thanks

@augustortiz 5 лет назад

amazing video

@nebukednazar 10 месяцев назад

more than perfect

@PatelAkshay 5 лет назад

thank you so much

@Sarapareche 5 лет назад

THANK YOU THANK YOU THANK YOU

@devilterminator7406 3 года назад

Keep the good work 🖤🖤

@afrifagyasiwaah 7 месяцев назад

Thanks

@mariemmohy9496 4 года назад

Thank you

@ionictotalwar6389 5 лет назад

thank you

@gayathrithakshila3235 3 года назад

Thank youuuuuu🤗

@caladbolge 3 года назад

dude you rock

@beautysparkles07 2 года назад

Amazing

@paphiopedilum1202 6 лет назад

Hey man, it might be irrelevant in this channel but please come back to your piano channel to continue Claire De Lune. You really helped me to start off :)

@victoirelacaille3009 4 года назад

how does the -s goes away before having palmitate ?

@aidatesfe4247 5 лет назад

very good video. nice explanation and not boring at all.thanks so much

@Chels-yk2ox 8 месяцев назад

is there a video on fatty acid breakdown?

@nikhitakumar 2 месяца назад

Wow nice

@vangalavenkatachalapathi8730 5 лет назад

Awesome

@georgeklucsarjr1988 2 года назад

Not a student. Does the process always stop with a 16 carbon chain?, or can other smaller and/or larger chains also be made? If so, are certain enzymes regulators for determining the length?

@sikemiitunu 7 месяцев назад

Yes the carbon atom can be longer than 16 and that is the usefulness of the last acetyl coA formed, it's used for elongation of the chain.... And yes, fatty acid denovo synthesis is being regulated by some hormones and enzymes...e.g to activate the synthesis, insulin, citrate are used while to inhibit it, glucagon, epinephrine etc...are used

@marwa5834 5 лет назад

how are 14 NADPH formed with 2 per reduction reaction? arent there 2 reduction reactions in each cycle with 7 cycles total ?

@femidaelettil1002 5 лет назад

At the end of 7 cycle 2 fatty acid is synthesised simultaneously (fas complex is a dimer).. 14 NADPH is needed for 1 fattyacid synthesis(2 reduction reaction×7)

@dr_shyma 6 лет назад

goooooood

@r1c3d75 4 года назад

In the formation of butyryl coA you haven't shown the formation of its keto acyl and skipped directly to the result i.e. reduction, dehydration and again reduction were not shown in the step for the preparation of butyryl coA

@sanjanalaksh 5 лет назад

Isnt it 12 NADPH ? cause NADPH is added only in the reduction unit and in reduction unit there is only 6 cycles , cause butyrl coA has 4 C atoms already so just needs 12 more . Im a lil confused

@hiroshiro7443 5 лет назад

I think he included the first one in the cycle

@Jan-ty8jz 5 лет назад

I'm a bit confused. Watched this as an overview before my exam as I don't have the time to go into details. You say the cycle goes 7 times with a butyryl-CoA as the template. The butyryl-CoA is made by combining an Acetyl-CoA and Malonyl-CoA giving off a CO2. Products from 7 cycles: 14 C added, 7 CO2, 7H2O, 7NADP+. You say we net 7CO2, but what about the one given off when we made Butyryl-CoA? Also, if the cycle goes 7 times, then we use 7 malonyl-CoA in the cycles alone plus 1 from making butyryl-CoA = 8? This is probably because I didn't read up on the finer details and is basing my knowledge on this video alone

@MisterVB Год назад

+ CO2 for acetyl coa carboxylase

@maniinani7675 4 года назад

Why it is necessary for fatty acid synthesis to complete 7 cycles?

@costancekhoza1815 3 месяца назад

Badly need synthesis of membrane lipids

@dradaezejoymadubuike7741 2 года назад

Plenty kisses for you. You just simplified the whole stuff.

@a2300_ 5 месяцев назад

Thank you for the explanation! Also would like to add, that as you have mentioned (in the summary) the utilization of 7ATPs in the acetyl-CoA carboxylase reaction, you should have also mentioned that in that exact reaction 7 CO2 are used, so the total production of CO2 should be 0, not 7

@balukajovia2487 4 месяца назад

im still not understanding fatty acid synthesis especially after the formation of malonyl

@calmrhythm6403 8 месяцев назад

I LOVE YOU

@harshitakaushik9058 4 года назад

Great video, but please increase the volume. Even with earphones at max volume i had to strain my ears.

@btudrus Год назад

Saying that ChREBP is activated by "calories" is very misleading. ChREBP is a pure carbohydrate (glucose, fructose) sensing molecule. So, for example, in the state of ketosis the cell have abundand "calories" available BUT it will not lead to FA synthesis. In other words, it is primarily carbohydrates which makes one "fat"...

@mohammadasifpatel748 9 месяцев назад

Wow

@preronaagogoi6247 Год назад

How 8 acetyl co A ?

@user-lkkljhi 3 месяца назад

coz malonyl CoA is coverted from acetyl CoA by acetylCoA Carboxylase (add 1 carbon group to it).Thus by balance the equation, end up its using Acetyl CoA while malonylCoA is just a intermediate