Funny you should ask - although I've been lucky and have had NO punctures or leaks, my back tire is worn - very little tread in the middle. The knobby off-road tires are getting worn. I've got over 500 miles, and they are probably a bit overinflated at 28 psi - but I'm considering getting road fat tires for a more smooth and quieter ride but I'm probably 50/50 road/trail.
I haven't had a problem with the liners shifting - at least none I've noticed by any uneven or out of balance rotating. I do keep the tires at about 25 or maybe even softer. I ride over rugged terrain primarily - a lot of gravel and dirt trails - and only had one flat after about 3000 miles. Very happy with the performance.