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Glutathione for skin lightening - Dermatologist explains

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The colour of our skin always seems to appear greener on the other side. Those with dark skin want to have a tan, and those with dark skin would like to be fair. A variety of supplements have been purported to make the skin lighter. In this review, we look at the role of oral glutathione is making the skin appear lighter. It is based on there randomised controlled trials in the last few years.
Combination of topical and oral glutathione as a skin-whitening agent: a double-blind randomized controlled clinical trial. doi: 10.1111/ijd.15573
Glutathione and its antiaging and antimelanogenic effects. Clinical, Cosmetic and Investigational Dermatology 2017:10 147-153
Glutathione as an oral whitening agent: A randomized, double-blind, placebo-controlled study. Journal of Dermatological Treatment. 2012; 23: 97-102
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Опубликовано:

16 авг 2024

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Комментарии : 63

@kevinmaran2659 Год назад

Short and sweet videos doctor, please keep it up

@DiscoverDermatology Год назад

Welcome Kevin, glad you liked it!

@vickiecharamita 10 дней назад

Me too

@rajagopalsundaram2681 2 месяца назад

Very good Scientific lecture given in a nice way Thanking you so much Sir 🎉

@DiscoverDermatology Месяц назад

Thanks Rajagopal!

@samanthakiu4055 11 месяцев назад

Philippines!!!!! Yes it's very popular here in the Philippines esp with our celebrities and models. IV glutathione is very effective for whitening and immune booster however oral glutathione is good as an antioxidant supplement.

@DiscoverDermatology 11 месяцев назад

Its interesting to note the history of the use of glutathione in the Philippines. Thanks for sharing.

@preeyaprasad8155 Год назад

Thanks doctor, as always another great and informative video. I’m a big follower now after a previous video really helped my condition. Where can you purchase topical glutathione?

@DiscoverDermatology Год назад

Thanks for your kind comments. I am not sure how many products are available in India. I have googled it and here is one I found on amazon India. However, Im sure there are quite a few other products and dermatologists in India may help you with it. www.amazon.in/Trycone-Glutathione-Whitening-Ageing-Vitamin/dp/B07RZXVBX4

@RohanYesudian Год назад

Interesting. Mechanism seems to make sense given the antioxidant activity of glutathione. Did they control glutathione levels in the diet of all participants or does supplementation provide a supramaximal dose which makes dietary glutathione negligible?

@DiscoverDermatology Год назад

Good point. They did not mention it in the study protocol. I suspect it will be difficult to control diets in a study like this.

@BestRara 9 месяцев назад

Thank You . Concise and informative .

@DiscoverDermatology 9 месяцев назад

You are welcome, glad it was helpful!

@rogerricrads9855 Год назад

Interesting topic, thank you!

@DiscoverDermatology Год назад

You are welcome!

@agscolony Год назад

Interesting video Diva

@DiscoverDermatology Год назад

Thanks mama!

@Whistle.Whistle 6 месяцев назад

intravenous Glutathione is way stronger than oral, due to oral's poor bio-availability despite lozenges first liver pass

@DiscoverDermatology 6 месяцев назад

Thats is correct. However, the long term side effects of IV glutathione are still unknown and may become apparent many years later.

@manisx7490 Месяц назад

@@DiscoverDermatology What about liposomal glutathione? for exemple is 500mg of liposomal glutathione more effective than 2000mg of basic oral glutathione? due to bioavailability

@DiscoverDermatology Месяц назад

@@manisx7490 Not sure. I have not used or researched into liposomal glutathione myself.

@simonsanjorin3751 7 месяцев назад

Hi Doctor, really great review. Can I ask if it safe to use up to 50,000 MG daily of Gluthatione, aim not for lightening but as an antioxidant and anti aging agent. I was told a product called glucenta diamond is good, but the dose is 50,000mg.

@DiscoverDermatology 7 месяцев назад

I have not heard of such high doses being used for skin conditions. It may be better to use natural modalities like diet to have young appearing fair skin. Here is a video on it. ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-cqvmt6bYWFI.html There are other natural ways of maintaining young skin. Here is a video called Healthy skin, which explains it ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-CB2D3NUTzDI.html Finally, using tinted sun screens on the facial skin will prevent darkening. Here is a video on it ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-u3cPL4T1g3c.html

@simonsanjorin3751 7 месяцев назад

@@DiscoverDermatology thank you

@jessie9671 8 месяцев назад

Would you recommend it to be taken for skin brightening and is it safe to take glutathione supplements Long term or is a break needed ? Thanks

@DiscoverDermatology 8 месяцев назад

It may lighten the skin in some of those who take it. However, not sure if it will brighten the skin. Making it lighter may result in a brightening effect I guess. The oral supplement seems safe in the long term but data of more than a few years is lacking at present.

@ari-jv 2 месяца назад

Make sure it’s liposomal glutathione

@DiscoverDermatology 2 месяца назад

Interesting point

@CDM723 Год назад

Jus like oral minoxidil which is not FDA approved, is glutathione too used by dermatologist in practice ??? Pls give your answer dr

@DiscoverDermatology Год назад

In the UK, its the opposite, most want to have tanned skin, so I have not had to use this supplement before. It is very commonly used in the subcontinent and in the Philippines, where not was first tested. In fact, I gather it is given as an IV rather than orally, which makes it more likely to have potential side effects. Most dermatology treatments are not licensed as the there are so many conditions where rigorous studies have not been conducted. Dermatology is mostly an "empirical" subject where doctors use medications that they have been taught to use even though many do not have the double blind scientific evidence that other specialities have. It suggests that more research is needed in dermatological conditions. I try to post research that is double blind and has proof that it worked in scientific studies.

@traceylennon1204 11 месяцев назад

I use Luma Glutathione I take 2 capsules 500mgs a day with a meal the way the directions instructed..will that lighten my skin?

@DiscoverDermatology 10 месяцев назад

It may work for some, but not everyone has benefits from the medication. There are a few creams that can help lighten darker skin on the face. here is an evidence based article that I reviewed earlier ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-nCAI4PE073k.html We also need to ensure that we prevent any sun induced pigmentation by using tinted sunscreens ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-u3cPL4T1g3c.html

@iilydaa 10 месяцев назад

Has your skin turned white?

@user-rq1ot8vp1z 4 месяца назад

Hi doctor, I am taking oral glutathione at a dosage of 500mg per day . Will it show me results . It’s been around 3 months I have already used but none improvement so far

@DiscoverDermatology 4 месяца назад

Supplements may not work in all those who take it. IIt could be beneficial for a majority but there will be some in whom there is no effect. It is important to combine oral agents like glutathione with topical agents like tinted sunscreens to ensure that the existing pigmentation does not worsen. Here is a video on it ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-u3cPL4T1g3c.html

@payalsingh4395 5 месяцев назад

Hii Doctor Had a lot of acne in my teenage but after consulting dermat got rid of those however those acne have remained acne scars which are called as pit scars. Can you help

@DiscoverDermatology 5 месяцев назад

You are right that scars are more resistant to treatment compared to the active lesions. A variety of treatments including topical retinoids, lasers, peels and dermabrasion have bene used. It may be best to see a dermatologist or Plastic Surgeon.

@shaaronimaagine8056 9 месяцев назад

Hii Thanks for the video, Does smoking affect glutathione??

@DiscoverDermatology 9 месяцев назад

There is no direct effect of smoking on glutathione as far as I am aware. For general skin health though, smoking is not ideal. Here is a video that explains this. This looks at all the life style factors that help us have good looking skin. ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-CB2D3NUTzDI.html

@deewanaalinoor Год назад

Dr mere nak pe scars he 1 wo sai nai hora 2sal se mene acne scars cream use ki he osse bhi sai nai hoa to Kia use Kare jisse sai hojayy opan pors bhi sai hojay

@DiscoverDermatology Год назад

Hi, I do not know Hindi but I think you are asking about the treatment of acne scars. I have not done any specific videos on acne scars but if they are dark in colour, the treatments mentioned in this video may help ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-nCAI4PE073k.html Also, make sure that the acne is completely under control. Here are a few tips on how to treat acne in Indian skin. ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-_4PPrl98mi4.html

@pinkcorner9989 Месяц назад

Is there any problem in taking pearlite max tablet 600mg for 3 months?

@DiscoverDermatology Месяц назад

Not sure what pearlite max contains?

@pinkcorner9989 Месяц назад

@@DiscoverDermatology I am in Wrexham . Can we get glutathione oral tablets here?

@DiscoverDermatology 22 дня назад

@@pinkcorner9989 Yes, it is available in most health food shops like Holland and Barrats. It is also accessible online.

@othmanabdul6231 7 месяцев назад

Doc, i have occasional pimples but when i do have it takes a while to go and the acne scar remains, the marks are darker and doesnt fade away whats the best way to get rid of it?

@DiscoverDermatology 7 месяцев назад

There are a few creams that can help reduce facial pigmentation. This vide covers a few of the evidenced based treatments for it. ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-nCAI4PE073k.html

@IanStylezz 7 месяцев назад

Can you recommend products that are good and safe to use?

@DiscoverDermatology 7 месяцев назад

There are a few creams that can help lighten facial skin,. Here isa video on it ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-nCAI4PE073k.html Using tinted sun screen will also ensure that the existing skin tone does not darken further. Here is a video on it ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-u3cPL4T1g3c.html

@IanStylezz 7 месяцев назад

@@DiscoverDermatology how about pills. I have those other products.

@wajeehamalik4611 6 месяцев назад

Dr can we take glutathione with traxemic tablet for melasma pls guide .

@DiscoverDermatology 6 месяцев назад

Yes, they can be used together.

@wajeehamalik4611 6 месяцев назад

@DiscoverDermatology thank you Dr. Prayers for you 🙏

@sirimaddala8661 11 месяцев назад

Doctor, is it safe to use topical glutathione?

@DiscoverDermatology 11 месяцев назад

Yes, there are good reports of topical glutathione being helpful too. There are other topical agents that can lighten darkened skin and this is covered in this video. The creams towards the end of the video are available over the counter. ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-nCAI4PE073k.html

@Ditchedshit 5 месяцев назад

Does it work on naturally brown skin ??

@DiscoverDermatology 5 месяцев назад

From the available literature, it seems to lighten the skin generally, but may have a more prominent effect when the sun has tanned the skin as the lightning effect may be more prominent there. It is important to use tinted sun screen if one wants top presence the existing colour and prevent it getting darker. Here is a video on it ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-u3cPL4T1g3c.html

@sweettyms5311 Год назад

Thank you for making this video. I'm in USA and this April 13th I took a Determetolagist appointment, I was gonna ask about glutathione 😅. We are planning for pregency this November. So is it safe to take glutathione now?

@DiscoverDermatology Год назад

Generally, most clinicians would like no oral medications to be taken when pregnancy is being considered. Even though glutathione is natural, there have been non studies about its effects on pregnancy. It may be worthwhile using topical (cream) glutathione as that may be safer in pregnancy.

@rakshashetty9626 10 месяцев назад

Can i taken it during breast feeding??

@DiscoverDermatology 10 месяцев назад

Most supplements are not tested in those who are pregnant. So it may be worthwhile avoiding during pregnancy. If used, a very low dose would be considered.

@KM-bc6pu Год назад

Its not really effective for skin lightening I have taken ivs not a single tone improvement I get from it I were bron with fair skin (yellowish) but unfortunately it changed long yr back mybe bad genetics or sun exposure..this all gluta brands just doing their business name of lightening

@DiscoverDermatology Год назад

You are right that not everyone will benefit from glutathione treatment. In every study, there is bound to be failure for at least a few of those who use it. Science just shows if it could be helpful for at least a group of those who use the treatment.