I have been on ozempic for a little more than two months, it’s not only curving my appetite, I don’t feel cravings, it’s easier to make healthier choices, I don’t wake up thinking about what I will eat, I don’t even think about food anymore, not only that, it reduces my cravings for my pain medication and the weight loss is allowing me to move more and my pain is getting better. This drug saved my life.
I love hearing this! I wish more people understood that it’s not just about weight loss but it also helps us lose our desire to eat the foods that cause the weight gain and by extension, help our brains see food in a different way and develop new habits.
It’s great that you lost weight, but 35 lbs can be accomplished in 3 months and no drugs involved. I’ve helped hundreds of men lose 30 plus pounds just with nutrition alone.
@@Biohackthefatwe know that. Most of us using these meds have been hearing that for decades. Think about why we finally ended up on this drug. We have known we needed to lose weight. We know the right way to do it. Why do you think we have not been successful?
@@PaulSpehar - I totally understand your frustration. I get super frustrated and upset as well, considering I am a health and nutritional specialist who has helped hundreds and hundreds of men over 40 lose weight naturally without these types of drugs. I get frustrated mainly because these companies are pushing these drugs, that have millions and millions in marketing dollars, and are causing undue harm unknowingly to individuals. Like one of my clients said, I have the "secret sauce" for weight loss, but I just need a better marketing system to get it out. Too bad I don't have millions of dollars to spend getting my system out to the general public. Instead I wake up at 4 am and scrap everyday trying to get my system out there, and fight to help men over 40 without these ridiculous drugs that everyone is so enamored about. It's plain ludicrous... everyone looks for the quick fix, which is going to be the downfall of this society.
About 3 months on Ozempic(1mg) and I have lost 20 pounds. I had not any bad side effects other than weight loss and a better insulin sensitivity. Thanks for sharing
Fresh veggies don't require any analysis. When money is not spent on snacks, cakes, sugar drinks, ice cream, junk foods, salty snacks, this money can be for fresh nutritious foods. I steam fresh veggies 90% of each week, my weight lose has maintained, because I prepare fresh foods. Walk one hour each day, weight lift resistance 3 x weekly. I was a fatty person....now normal for the last 30 years. The best gift we can give our ownself is balanced nurturing foods. Buy fresh...😮
Those depression cases, you say due to the rapid weight loss... maybe more accurate would be due to a starvation, which led to the weight loss? The drug literally stops people eating as much to maintain the body weight, and most likely they will be malnourished. Over weeks and months. Just because one brain centre thinks everything is OK, that doesn't mean it is OK.
If this drug has been given for decades to diabetics.... do they have side effects like nausea? Slow gut bowel issues? Thyroid cancers, depression, etc? Do diabetics lose that weight for life? Must be different drug - semi gluetide What if you have IBS? Other gut /thyroid /adrenal issues ? Big win for pharma to have 12 year olds on it for life ..... and not care to treat cause of obesity. Big win for processed American food industry
I have been on Ozempic for four months and lost 20 pounds. The bad news is that I am sick to my stomach all thr time, plus stomach pain and back and forth bathroom issues, violent vomiting sometimes after my dinner, and lethargy. My sugar dropped the other night, I passed out and fell backward. Hit my head, back and neck. Now I have more problems than just being overweight !!!
There are many videos about this class of meds but this is by far the best, most comprehensive and without oversimplifying video I’ve run across. Thanks!
These are risk factors for people not on Ozempic but the main risk factors for pancreatitis and pancreatic cancer are smoking and alcohol consumption as well a vitamin D deficiency for good measure. I have the issues of diabetes and insulin resistance and obesity and I have not had an episode of pancreatitis yet. I am not on Ozempic because I found I could not tolerate these drugs.
Is pancreatitis and gallstones not a possibility for anyone who loses weight, especially quickly? So could it be that it's weight loss too quickly that can cause these issues rather than the actual drug itself?
My experience with Ozempic was not a good one, after 6 months I had to discontinue the use. The side effects were just to awful to continue with the medication. I'm so happy for the people that had success on this program.
@@iantercero5380 I became so constipated (sorry maybe TMI) that when I did have a bowel movement it was so painful that I felt I would pass out, I would sweat and tremble until I would throw up. I drank water all day long as I was told to do. I decided to ask my doctor to change me to another medication for my diabetes. I will continue to watch what I eat and not fear the once weekly painful movement. It did suppress my appetite, but I just didn't feel like myself, I slept a lot and was told that I was very moody. I'm sorry I didn't like that. I'm so happy for everyone who have had success.
@@JossBailey-v5c I would become so constipated that when trying to get relief I would throw up, sweat as if I was in a suna, the pain was so awful I thought I would pass out. I drank coffee, I drank so much water, I think I could feel it moving around my inside when ever I move, and headaches. I'm just one of the people that it didn't work for. I hope everything thing works out for you. Please let me know if you have a good experience.
Ok for people considering".I’m 82..years of age and I need to loose 10 kilos,I was 86 in December now I’m 79….than now I’m off ozempic.".at first I got a red box .2:1…I think it was .and I had nearly no side effect..I fell a bit tired..i couldn’,t find 2.1…anywhere so I took 5.1
If you get off semaglutide and start eating like before (not watching your calorie intake) you ofc gonna gain weight. It would be interesting to see if people could maintain their weight loss if they kept the life style changes and not just throw everything out and start eating pizza all day every day ;)
I’m eating exactly the same as I did before starting the 💉and I’m 50 lbs down now. Obviously the medicine is correcting an issue my body was having, because the food/exercise is exactly the same. The food wasn’t the issue, it was my hormones. Just like with my hereditary hypertension where I will have to take a pill for the rest of my life, I’ll have to take a shot the rest of my life, too. And I’m totally grateful this exists now. This might have saved my dad’s life if it had been available. Studies have already been done that if you give someone a placebo after taking it a few months, despite eating the same calories, they gain the weight back. So pizza isn’t the issue. There’s something deeper at work.
I begged to be prescribed this med, my doctor said my BMI wasn’t high enough (it was 40.2), I ended up doing the lumen metabolic tracker instead and lost the weight without medicine, 🤷🏻 weight loss is weird. My BMI has been at 23 for a few months now, it took 13 months to get there
Please can you explain scientifically why for a small number of people, the injections are just like injecting water. No side effects, no appetite suppression/ no fullness . Is it something to do with their receptors or their previous diet and exercise history? Also the effects wear off the longer you take the drugs. Is this just the body developing tolerance to them? Thanks in advance
Those are fantastic questions! I've provided a QA breakdown below... Q: Why are some people minimal- or non-responders to GLP-1 RA treatment? A: As you mentioned, there seems to be a fairly wide treatment response to GLP-1 RAs (i.e. semaglutide). Some preliminary animal and human data suggest that variations in the gene that codes for the GLP-1 receptor might account for some of these differences in responses to treatment. There are also some related pathways that probably have genetic influences, but there has been more research about their relation to blood glucose, rather than weight response. Beyond that, other physiologic factors such as co-morbidities could play a role. I think that we will know a lot more in the next couple of years. It will be interesting to see whether any of the newly developed multi-receptor drugs (i.e. GIP/GLP-1/Glucagon RAs) achieve different results. More to come on that soon! References: Genetic variability in GLP-1 and weight loss in PCOS: pubmed.ncbi.nlm.nih.gov/25991051/ Genomic analysis of glycemic responsiveness to GLP-1 RAs: www.thelancet.com/journals/landia/article/PIIS2213-8587(22)00340-0/fulltext Q: Do the weight loss benefits of GLP-1 RAs continue indefinitely, or do individuals develop tolerance? A: Although these drugs have been around for a while, it is surprisingly difficult to find longitudinal follow-up data that goes beyond a couple of years. Weight loss tends to plateau after about a year and weight remains fairly steady for another year (www.nature.com/articles/s41591-022-02026-4). After that, we really need longer-term data to know for sure what the trajectory is.
@@sterlingmdphd Thank you for your detailed response. For the second part, I was thinking more in terms of the appetite suppression and fullness that seems to wear off after a while for some people . I suspect the body develops tolerance to it . Do you think they will ever raise the maximum dose ie. Higher than 2.4 mg?
That's a really interesting point. I'm not aware of any data that is out there that could shed light on this particular question. My hope is that we will have more studies in the coming years to understand why some people report different experiences over time. It is certainly an important thing to investigate.
Regarding the second question, i think there could be a tolerance effect. I took the starting dose of 0.25 for 10 weeks before bumping up. I started noticing the appetite suppression and feeling of fullness weren’t as strong around week 7 or so, and my weight loss plateaued around 9 weeks (14 pounds down). Week 11 I went up to 0.5 but the scale still didn’t move. Week 12 I mixed up my injection site (thigh vs belly) and I’ll be darned 7 more pounds came off by my week 14 weigh in!
The percentage of people who don't lose much weight is not insignificant. Just like diabetics who are insulin resistance, in people who are obese or diabetic, they are resistant to GLP-1 as well. Their fasting levels of GLP-1 are elevated compared to lean, non-diabetic people. People who don't respond to Ozempic are more resistant to GLP-1. The people who lose the most weight with these injections are those who are most metabolically healthy.
Hello Nick. Your videos are extremely good, better than most videos I see. You are very good at simplifying complex subjects. If you keep going I predict that you wil become very well known.
I had the willpower, strength and dedication to try and lose weight on my own….. not artificially…..I’m not into feeling nauseous and weird all of the time and that’s all I’ve heard from the people who are currently on it.
Is it possible that Semaglutide could increase the number of GLP-1 receptor sites making it far harder to keep the weight off when the medication is ceased?
Ozempic saved my life, in reality, if you want to take the drug just for weight loss, you are better off sticking to calorie counting and exercise, but if you have diabetes, ozempic is really a life saver. This drug changes lives, it’s a very small percentage of people that experience bad side effects.
Someone who works in the pharm industry: this drug has a FDA warning for thyroid cancer. Please be advised by health professionals regarding warning before using.
My understanding is that this is stictly from the animal studies (specifically mice) and that even after the 6 years it's been on the market, there's been no statistically significant increase in this risk to those using Ozempic.
Then you also know that during drug studies anything that happens or is reported becomes a side effect of the drug! What's the alternative for those that are taking this medicine for weight loss? Hypertension, diabetes, heart failure, knee replacements, cancer! Death! Go to your doc appointments,have your labs done as suggested! Just knock off the scare tactics!
Its ONE very rare form of cancer called medullary thyroid carcinoma …that is common in rats and mice. They did not see any of this cancer in the trials for humans, only the rodents developed it and they had about 30x the amount of medication. The rats also have specific glp cells that have receptors for glp-1’s where humans dont have that receptor. They have to put the black box warning because of the animal data. Obviously if you have a family history of this rare cancer dont take it, but the fear mongering with these meds need to stop.
Ozempic made my blood sugar go from 519 to 228 in just 1 week (I am also doing carnivore). people are abusing it to lose weight and then it is causing side effects for them. They will mess around and cause it to be taken off the market.
Every bad Ozempic story does seem to involve abuse of it. One notable one the person was throwing up and had diarrhea for months but didn't stop the treatment. Even if the drug itself wasn't doing damage vomitting over an extended period of time is not going to be healthy.
Would you provide the reference supporting the statement that ".... inflammatory changes in the brain like gliosis and scaring ..... "and that is hsa an effect on neurological signaling as relates to weight and weight gain? After a pubmed search I can find articles in rat models that then are used with "observational data from postmortem samples" of people but it appears to have some limitations in interpretation. But you raise an interesting point that I would like to dig deeper into. Thanks for the information.
Sure thing. This is a good one to start... pubmed.ncbi.nlm.nih.gov/26530930/ Much of the brain changes with caloric surpluses and LCSFAs are thought to be mediated by microglia, which form what is referred to histologically as a "glial scar." I did an episode on the topic a while back and covered some of that towards the end. The episode and all of the references are here... www.nicksterling.com/2022/11/25/4-how-overeating-rewires-our-brains-the-neuroscience-of-obesity-weight-gain-weight-loss/ It's a fascinating topic. Thanks for your comment!
Great video. It's so sweet when you find what works and start losing that unwanted weight. I lost 42 pounds in less than 3 months and have kept it off since then. Key thing to note is that I exercised daily for months, but my issue was the struggle with my calorie intake. It was just impossible for me to eat less. It felt like I wasn't in control of my actions. Adding Phenq pills to my journey just made things easier. Eating less became possible and I also had enough energy to exercise. I talked about this extensively on my channel, though
I agree, i did it low dose for 2 weeks, no desire for food or cravings. I went off it because im going on vacation and i like to drink with friends. So if 2.5 lasts for a couple of weeks why go on a higher dose? When i come back from vacation i will do a small shot. Have no plans on going on a higher dose. I have no need to lose 50 pounds, i dont want the saggy xtra skin between my thighs. Im 5 9 and weigh 215. Most of my fat is in my belly like a man. On it for 2 weeks and lost 9 pounds. And been off it for a week and food is still gross.
I am grieving the loss of my mother starving herself to death (3/25/24) due to this drug. She couldn’t eat or drink - no appetite, nothing tasted good, trouble swallowing, severe constipation, dehydration, depression, kidney failure, the list goes on. Please be careful with this drug
I was on Ozempic for about a year and a half but all it did was make me sick I never lost a pound until I got off it and lost 10lbs. I had to be on a lower dose than the doctor wanted because it was constantly sold out for those wanting to lose weight, I am a diabetic.
What I miss most from the GLP 1 medication is how CALM it made me feel! Mentally it grounded me. Is there anything natural I can take to mimic the brain effects GLP1 has?????
Right after I took the shot, I tasted the medicine in my mouth and throat. I had the worst ever explosive diarrhea for a week and Imodium AD didn’t help. I didn’t take another shot and haven’t been to the bathroom for a week. When I was on the medicine all my fluid was going to my bowels and not my kidneys and I was only urinating about 6-8oz a day. Both my kidneys hurt. The food was not staying longer in my stomach. I saw what I ate an hour ago in the toilet. What I learned is I’m going on a limit what I eat diet. Make what I eat count. It all comes down to portion control and eating a variety of foods. I’m glad I took the shot. It told me there’s no magic pill or shot. But there is the gastric sleeve. I wouldn’t mind having that done. So if you’re about to take your first shot, don’t be afraid of the little needle. Be very afraid of the chemicals flowing through your body. Once you take that shot you’re committed to it for a week or more. It’s not like taking a pill and then stopping it. It’s a 7-10 day commitment with all the side effects. The side effects alone scared me into sticking with a healthy diet on my own.
Gastric sleeve isn't any better. I have friends who had it done and you have to literally eat all the time, which I do struggle to do with pcos but am still fat. You also need to take supplements or you will die because you can't get enough through diet. Supplements are expensive and also you need to stay on them. Idk no thanks. They always look so unhealthy.
I believe it depends on the person some people do not react well to these medicines obviously you. But not everyone has these issues. Its funny these guys are trying to discredit this medication because it didnt work for some people or some had reactions or they just don't believe in them. But for some of us with insulin resistance we are praying the FDA approves this sht. Don't believe everything they tell you about the sleeves. Weight loss surgeons are losing millions rn.
Oof, sounds like my experience using Depo-Provera! I felt the effects immediately and since it's was a 3-month injection, I was just stuck dealing with the side effects! Research medication before you take it, no one told me that that particular female birth control is actually male chemical castration for pedophiles : | Yeah it went as good as you'd think!
Ozempic is a tool to help lose weight you still have to learn how to eat better and move more. Its similar to weightloss surgeries. They are only a tool, if you dont change they way you think about food and how you eat you will gain it back.
People don’t really need a drug to lose weight. They need a mindset and be consistent. The only way this drug helps people lose weight is to punish them with side effects until they change. I can do that on my own and not be punished with kidney damage, thyroid cancer, vomiting and nausea. Oh and don’t forget insomnia. Need drugs on top of drugs to treat side effects. Some people love it and they are dying to be thin. Let’s see what happens 10-15 years down the road.
I think food is an addiction, just like alcohol and drugs. Many people dont realize fat is just stored calories which is energy and weight loss basically comes down to calories in vs calories out
It works well for me and I have no side effects except insomnia... but this one issue almost makes it not worth it. i'm gonna wait to see if it goes away in a month. if not, im coming off.
The fact that the name is already so widespread after coming out of nowhere and lazy celebrities are begging for it when they have all the money time and resources in the world to work out with personal trainers tells me everything I need to know. It's probably got an addictive component and is most likely hiding some sort of horrible side effect that we won't be told about for another 30 years.
Yeah, that's what I'm worried about, the long term effects that this drug may have down the line. I was considering it, because I need to lose the weight, but I don't think I will.
I’ve been on GLP-1 compound for about 3 weeks. Side effects so far have been minimal and I’ve lost 4 lbs. I have Hashimoto Thyroiditis and my doctor is seeing amazing results in not only weight loss, but the complete reconstruction of the metabolism. It’s still early, but so far so good. If you have Hashimotos talk to your doctor about this class of medication.
Hello I just recently saw your video and I was on Ozempic for a little over a year and I just could not handle being nauseous all the time. I stopped it and have been off it for around 16 months. I’m pleased to say I have not gained weight back but I worked at it by still following my health changes. I lost another 12 or so pounds but absolutely no matter what I do now I cannot lose anymore.
@@mon1476 31 lbs is a huge weight loss. Plateaus exist for everyone. If you move your body and hit a caloric deficit your body will regulate and lose. Increase activity / intensity and after doing that for a while, then I’d see your doctor.
I still need to loose a good 80 pounds. It’s very hard I have been very disciplined. I’ve incorporated a lot more walking daily. Can’t do too much extra yet cause it flares up my fibromyalgia
Thank you so much for that grrat info. Please consider not using music behind the speaking. Many of us cannot easily process the imore detailed nfo with that distracting background music. Thank you.
Great video! I’ve been on Ozempic for about 8 months and have lost 35 lbs. the beginning was tough with the side affects. I don’t have all the nausea anymore but do feel full faster and quite a few foods are not as appealing as they used to be. I do feel like eating, not the aversion to food like in the beginning. I am trying to eat a lot less knowing I can live off of way less food even though the ability to eat more is there unlike at the start only a few bites would be tolerated and quite often throwing up followed. I have to be very conscious of my food choices now that all the side affects are way less and am able to eat most things again. I still have a terrible sugar eating issue. Probably out of old habits that I have to seriously get under control. And snacking at night . Even if I can’t stop that out of boredom I HAVE to make different choices like carrots and celery in low fat dip. It’s just mindless munching.
“Low fat” it’s crazy that people still think eating low fat will lead you to sustainable weight loss. We’ve been brainwashed for generations. I get it, but it’s time to wake up.
Thank you for such a clear and concise explanation of this medication. You articulate and explain it and an easy to follow along format. I appreciate you taking the time to create this Contant on your channel, and I just subscribed as I hope others will do as you continue on your journey to teach others.😊
All drugs have side effects and no one knows the long term side effects of this drug. Predict it will be taken off the market and we will be seeing advertisements from lawyers on TV saying “if you took….. and were injured or your loved one died… call us for compensation against drug company.”
That happens with almost every drug out there and with ambulance, chasing lawyers, chasing big Pharma money I’m sure it will. The truth is I’m sure this is very harmful to certain small segment of society. Such a large swath of society tolerate these medication’s as well that at this point, it doesn’t seem it should be taken off the market market.
I’m on the starter dose and I’m HUNGRY all the time. Im type 2 diabetic. I was doing so well on Mounjaro but my insurance won’t pay anymore. I have hormone issues and complex hyperplasia with atypia so maybe that’s why. Im so confused
I'm trying understand why I've been on this medication for 6 months and I've lost 25 pounds. I've also gone from a 43" waist to 36". I feel great and have a lot of energy. But, I'm trying to understand why I'm losing size faster than I'm losing weight.
New Subie here! I just started recording my content and how I’ve been losing weight and inches on ozempic (semaglutide) It def quiets the food noise. I like that! Great video
I lost 10kg on ozempic. I had to stop because I couldn’t obtain due to supply. I regained 12kg my appetite was out of control. I couldn’t stop myself I was eating rubbish like chocolate, ice cream chips cake soft drink. I’ve never done this before. Now I’ve gone from 82kg to 95kg. All the cravings have gone thankfully but so has my appetite for any kind of healthy food. I now eat anything to satiate my hunger which isn’t too bad now. My b12 has plummeted to 130 because I’m just not interested in food anymore. So now I’m not only fat but putting my health in danger.
I wish the medical research industry would do better science. Weight loss is NOT a healthy goal, fat loss is. If the researchers are measuring weight but not body composition the data is useless.
Well this simplifies what the drug does, thank you. However my dr keeps telling me to take ozempic despite me telling her I have absolutely no problem controlling my macros, calories/food intake. So If i'm eating a sugar free, balanced macro, essentially Mediterranean diet, exercise and strength train regularly, how do I get my PCOS riddled body to burn the fat I have so I can lose weight? Without Ozempic or Bariatric surgery, seeing as all both do is suppress appetite.
I also think these drugs affect the brain’s dopamine system - at least initially or when the dose is increased. People with RLS like myself may experience restlessness even if they are being treated for this disease.
On the long term study- did their sugar cravings decrease ? Anyone in this? Did your cravings decrease? Did you get acid reflux with the nausea ? Depression is gut related :
@@charlesdean640 take yourself to the doctor because one of the symptoms which is dangerous is the paralysis of the gut. Not saying it to scare you, just that you ought to make sure it's not an issue.
I’ve been on ozempic for 5 months and have had no side effects whatsoever, I’m obese but not grossly or ultra obese. I’ve lost 20 pounds so far. I’ll check back in a year
Thanks for this video. I am trying to lose 40 pounds and am considering these type of drugs but am worried I’d have to take this class of drugs for the rest of my life to keep the weight loss once achieved. Have there been any studies or anecdotal data on what happens to patients that take these class of drugs, achieve the results they hoped for, and then stopped or tapered off?
What did you decide to do? Did you go on the drugs? My concern is pancreatic issues, cancers, and other things we won't know about for a few years until these drugs have longer term studies.
I think between the threat of certain cancers, the nausea, mental health risks, and the thought of losing my hard earned strength in the gym due to not being able to eat enough to maintain my stamina I’ve talked myself out of it. I need to lose weight, but I feel like most of what I’ve seen is far less healthy than what I’m currently doing. Whole foods, strength training, and cardio. I’d love to be thinner, but at what cost?
I'd keep in mind its been used for quite a while by diabetics without any outcry. Its only once it was used for weight loss the campaign against it started. I tried it and it worked for me - unfortunately I can't get a supply in Australia. I lost 7kg in 6 weeks on it, before that I was losing no weight despite careful diet and daily exercise.
Keep going because you will reach your goal and you will have also gained the necessary discipline that will keep you healthy and fit for all the days of your life. It’s totally worth it and you feel great from knowing you did it the right way. 👍
