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How Aging Leads to Major Diseases and What We Can Do - Eric Verdin | Existential Threads 

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1 окт 2024

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@Cass-gi4kk
@Cass-gi4kk 3 месяца назад
People talk about diet and exercise cos they are the only things we know to be the most effective. Anyone who’s being in fitness all their lives know the quality of life they achieve compared to their peers. It wouldn’t even matter if I lost few years of life, I’d still exercise because it’s amazing for your mental and physical every day life.
@existhreads
@existhreads 3 месяца назад
Yes, Eric says this too - that it's not only about the future but about improving our quality of life today. In any case, I think moderation is key so it doesn't take over our lives. What kind of fitness do you do that feels so good? I'm curious. :)
@dharma__3
@dharma__3 3 месяца назад
@@existhreads Exercise doesn't actually "feel so good", but doing it (both cardio & weights) keeps me healthy.
@MBT372
@MBT372 3 месяца назад
My mom has been sedentary her whole life, her food consists of mostly carbs and little protein and at the age of 88 she’s in great health and sharp memory.
@dharma__3
@dharma__3 3 месяца назад
You forgot to add that she eats junk food, smokes and drinks, right?
@MBT372
@MBT372 3 месяца назад
@@dharma__3 lol no, no smoking, drinking or processed foods.
@laulaja-7186
@laulaja-7186 3 месяца назад
Wanting to be a biomedical researcher more than a clinician, isn’t that true of most of us?
@petervafeades4095
@petervafeades4095 3 месяца назад
stress reduction quality sleep and socialization may be as or even more important than vo2max, for example, in terms of healthspan
@dharma__3
@dharma__3 3 месяца назад
People are more interested in biohacking because our lives are being cut short and sickened with so many deliberate toxins. The key might be a cleaner environment (as much as possible) and detoxing.
@existhreads
@existhreads 3 месяца назад
Do you think that if we eliminated all toxins, biological aging wouldn't drive diseases?
@dharma__3
@dharma__3 3 месяца назад
@@existhreads Do you actually not realize it wouldn't happen nearly as fast? 😂
@existhreads
@existhreads 3 месяца назад
@@dharma__3 Haha yes, that's true about a lot of things. But the factor that makes you vulnerable to these external threats is aging. That's why the flu is benign for some and deadly to others, right?
@douglaswatt1582
@douglaswatt1582 17 дней назад
I do not agree with the hyper cautious interpretation of the literature on diet exercise sleep and social connection as simply correlational. I appreciate that this hyper cautious and skeptical approach is fundamental to good science but I do not think Eric does justice to what we actually know. We know from piles of work both in animal models and in human studies that all of these lifestyle factors funnel down into the core networks controlling the aging and age-related disease biological processes including: the regulation of inflammation, insulin sensitivity, mitochondrial function, DNA damage and repair, cellular senescence, autophagy, and we also now conclusively have mapped how the mtor networks have their fingers so to speak and every one of these pies. The science is looking highly convergent and not nearly as mysterious and as tentative as Dr Verdin would lead one to believe. An additional problem with this podcast is the fact that the interviewer knows almost nothing about the science and thus cannot ask particularly informed questions. Together these problems dilute what are the really constructive messages namely that the biology of Aging does in fact unite an understanding of the diseases of Aging which our current medical establishment mostly fragments and obfuscates - what I call the "boxology model" of these diseases. This is both misleading from a mechanistic standpoint, and massively wasteful from a resource standpoint, leading directly to the impoverishment of prevention.
@debbieseid8109
@debbieseid8109 3 месяца назад
So what does he have to add to diet exercise and sleep they talk around it, but I haven’t heard an answer yet
@existhreads
@existhreads 3 месяца назад
Hi Debbie, Eric has a lot to say about lifestyle changes to benefit long-term health. I recommend that you search for his talks. I intentionally avoided this as the focus of the conversation, because I believe that highlighting the need to make progress in science would be more impactful. @DrAndrewSteele explains this really well in his video: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-4qWeVh88Ggs.html But if you'd like to hear more about health hacks, the interview with Matt Kaeberlein offers advice you might have not heard of: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-70EeohZQubU.html
@Chris-tw8fu
@Chris-tw8fu 3 месяца назад
Spain is the healthiest country….wishful thinking because you live there
@existhreads
@existhreads 2 месяца назад
Haha could be. I actually don't feel my trajectory will be similar because I'm not assimilated enough for it to impact me. I don't live their lifestyle and don't have the close family/community bonds and traditions they have. But I look at how they live and it does give me a sense that they are doing something right...
@mauricek3572
@mauricek3572 3 месяца назад
Good work. Longevity is a mindset. Im 71 and work 6 days a week still working and learning Python programming.
@existhreads
@existhreads 3 месяца назад
That's so interesting. I can definitely see that having passion for what you do, being curious, feeling connected, and having something to look forward to are much more powerful in terms of healthspan and lifestpan than drinking your 'healthy' smoothies.
@dinomiles7999
@dinomiles7999 3 месяца назад
What do you do for work ?
@PhillipYewTree
@PhillipYewTree 3 месяца назад
I’m 72 and retired. I’m happy with the freedom I have.
@PhillipYewTree
@PhillipYewTree 3 месяца назад
Western medicine focuses on “ill care” and not “health care”. Naturopathic medicine and Chinese medicine have a different perspective.
@geraldtong4414
@geraldtong4414 3 месяца назад
Actually he's offering zero content other than exercise, sleep and eat well. He is just trying to discredit the rest of the researchers and promoting his own research firm. He mentioned the rest are doing marketing, he is also doing marketing.
@existhreads
@existhreads 3 месяца назад
As Andrew Steele said in a previous episode, it seems there isn't that much we can do right now on the individual level that is backed by science. As Eric says, a lot of people are experimenting now with supplements, but we need to be aware of the risks. Also--beyond the instrumental diet-exercise-sleep-etc type of recommendations, I get the impression that living a fulfilling, connected, purposeful life can do much more than we give it credit for. And it also makes life better right now. Better be disappointed with how 'simple' the answer is than deluding ourselves thinking there are cures out there that are safe and proven. But if you'd like a deeper dive into optimization advice, I recommend checking out this episode with Matt Kaeberlein: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-70EeohZQubU.html and his channel Optispan.
@geraldtong4414
@geraldtong4414 3 месяца назад
@@existhreads We do not need to listen to 1 hour of him talking where the conclusion are diet, sleep properly. The 60 mins is for him to discredit the rest of the people and sell his research firm.
@jcthomas5839
@jcthomas5839 3 месяца назад
The interviewer is awful, shut up and let the doctor talk.
@Kitiwake
@Kitiwake 3 месяца назад
Making videos longer.
@BrianSladek
@BrianSladek 3 месяца назад
Great interview! Interesting and Exciting stuff
@Roberto-cg2gr
@Roberto-cg2gr Месяц назад
What is the effect GKI to longevity?
@existhreads
@existhreads Месяц назад
Good question! :) I hope we have more educated viewers who can give a thoughtful response. Wondering what it is specifically you are looking to understand?
@ichich1298
@ichich1298 3 месяца назад
my mother is 93, she dose not take any pills, she was driving till 2 years ago, shs still lives alone, she never exerciced or did a partikular diate. my grandmother was 96 and still in good health, tow of my great grandmothers wer in their 90th.
@existhreads
@existhreads 3 месяца назад
Looks like you've won the gene lottery :)
@gormleyb3
@gormleyb3 3 месяца назад
One thing about people that age is that for a good part of their life there were no processed foods. So it’s easier to start out in decent health. Many of those people continue eating the way they-became used to.
@ichich1298
@ichich1298 2 месяца назад
@@gormleyb3 so the simple answer is, no processed food.
@gormleyb3
@gormleyb3 2 месяца назад
@@ichich1298 Well there was more to it, of course. People walked more too. It was a different world.
@edwardscott2510
@edwardscott2510 2 месяца назад
Yeah and move and lift and get all ur minerals with a blood check ​@ichich1298
@y.g.1313
@y.g.1313 3 месяца назад
Buck institute boss - useless
@dinomiles7999
@dinomiles7999 3 месяца назад
WRong ! ❤😢.
@dinomiles7999
@dinomiles7999 3 месяца назад
Zero principal thinking ! HE CANT SEE IT ! Most people have it WRONG . 😢.
@deniseosborne6727
@deniseosborne6727 2 месяца назад
Very interesting! Thank you.
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