I have been working on a bigger project these weeks that is very difficult to get right, I hope to still get to finish it in the way I want to, but it will probably take a while. At the same time I don't want to upload too little so I will take on some shorter and more established syntheses inbetween. For now, enjoy this potassium prison. Also, ideas are welcome 🙂
Salvarsane, the first antisyphilitic medication. I know you've already had experience with arsenic and it is not as horrible as it is expected to be, just as cyanide (don't eat=everything ok)
@@Tyresio12 crown ester 18-6 is way cheaper and is capable of dissolving KMn04 in non polar solvent, cryptand is more of a scientific curiousity subject (for making Na anions or other obscure stuff)
Bro, make a pure negative charged liquid by imprisonment of potassium
10 месяцев назад
A little trick that I like to use for hydrogenations like this is opening both valves, letting some hydrogen escape until you hear a change in pitch of the whistling. At that point you know its basically pure hydrogen coming through and all other gases have been purged.
I love the detailed mechanisms and diagrams (like the Pd/C one)! A lot of organic chemistry youtubers will show reaction schemes but not really show mechanisms. It really helps make your content more approachable to someone who isn't super well versed in organic synthesis.
Someone in my lab was using sodium azide for a synthesis, and the procedure he was following called for DCM as the solvent. He didn't tell me at the time and put the residual azide and DCM waste into a labelled P-listed waste container. A few months later, I find this container in the back of his hood... that was a fun call to EHS.
Waste disposal methods are always interesting to see. Especially when there are risks with storing it. As always, there is no one "right" way to deal with it and sometimes seeing something I might do is educational. Oh, and thanks for another interesting video!
I have been waiting for another of your videos for a long time it seems, thank you so much for making this one sir! I understand that things takes time and i am looking forward to your other projects no matter how they go really.
I worked in a research lab for 3-4 years designing and handling PEG ethers. I see those Tosyl and Trityl derivatives in my nightmares. We made some azide derivatives too but the carbon to nitrogen ratio was well over 3
@@monika.alt197Right? I think it’s pretty cool that the sulfonyl group of TsCl reacted with the alcohol of triethylene glycol in something akin to a nucleophilic acyl substitution reaction. I didn’t know you could do that with sulfonyl groups but it makes sense now.
this is so awesome, I'm a computational chemist/biologist working on chemosensors and their affinity to their ligands, and am literally working on publishing a paper over a type of Cryptand right now, so seeing this video come out from my favorite chemtuber is so cool.
Realistically, I think these are the best chemistry videos on RU-vid. You sure do like your chromatography columns though, even if this one wasn't used that way.
An explosion at a kilo lab (a lab used for syntheses of chemicals in kilogram amounts for research) in 2008 was believed to be caused by diazidomethane accumulation in a rotavap.
I used to work for chemical company that produced crown ethers. I mostly made 18-crown-6, dibenzo 18-crown-6 and dicylohexano 18-crown-6, made by hydrogenating dibenzo 18-crown-6. I worked on a pilot plant scale most of the time.
I know near nothing about chemistry, but those big rings made me think of catenanes, and I always wondered what a catenane polymer would be like. Like a molecular chain.
So I have a suggestion for a video, I know it's been done but if you're looking to do some stuff with established syntheses: Synthesis of Chromyl Chloride. It's a beautiful and interesting compound and also Hella spooky to handle so that should be fun! As a bonus, like me Nigel loves the stuff so there's a decent chance he'll drop by to say hi and you guys can compare your executions of synthesis. Alternative: Bromine! Anyways, thanks for the cool video, keep up the good work!
If you want a good eluent for the diazide product I used 80% Methanol in DCM, sometimes even 90% methanol in DCM. They REALLY don’t separate well, also I was working with hexaethylene diazide, so maybe it would be easier, or maybe harder, I’m not sure. But I agree, it is frustrating. We usually used excess sodium azide to avoid this.
In my experience with hydrogenation, using a rubber balloon filled with hydrogen is better so you can keep a constant higher pressure of hydrogen on the solution to increase the yield.
Here is a better way: Starting from your starting reagent of triethylene glycol, do an Albright-Goldman oxidation to the dialdehyde using acetic anhydride and DMSO. Purify by distillation to remove the acetic acid byproduct. Do a reductive amination via a modified Leuckart reaction using ammonium formate and 2 extra equivalences of formic acid. Purify by recrystallization as you do. Only a two pot reaction pathway with very minimal byproducts that are super easy to remove, and most reagents should be inexpensive and readily accessible.
i read a while ago about people making thins on a molecular scale like a "car" obviously that's a loose definition but anyway my question is would this molecule be any use in that field? if you haven't read about it before its very interesting subject and i read about it years ago they probably improved it a lot more its basically the start of nano tech
Is the imbalance in charge after locking the potassium in jail enough that you can measure? Wondering if you could use this to make a very terrible, but working battery.
I'm the student studying organic synthesis on polymers. Could you tell me which program to draw chemical structures on your video I'm a big fan of your videos. 😊
Hi, I've just learned about Tholin, a very interesting stuff which can only be found on other celestial bodies like Pluto (the reddish dust on the surface). Now I wonder if this can be synthesized in a lab. en.wikipedia.org/wiki/Tholin
@@TjallieBrrr it stinks, hard to remove from your product, makes me infertile, stinks, and was the solvent in a hard reaction during internships. Also it stinks.
Nile red one of the biggest chemistry youtubers: PD/C can make hydrogen explode if there's air present, but i don't have any nitrogen to flush the apparatus This random guy: I just putted in nitrogen before hydrogen, i'm not gonna even say why.
A probably stupid question. Why didn't he react the ditosilate product with amonia to directly have the amine compound? Isn't amonia a sufficiently good nucleofile?
The formed primary amines (product) can react with the tosyl substrate (especially since primary amine is better nucleophile than ammonia) leading to a whole range of oligomeric products of various lengths.
@@user-xb5qt2qn6i depends where you are. Can’t buy it in the US as a private person without a business need because some dumbass kid unalived himself with it a couple years ago.
@@ChemiolisI've always thrown them away when they turned black like that and no solvent would wash it off, but i guess that since no solvent would wash it off actually means that it's probably not interfering with the chemistry you're doing
@@levtrot3041 I haven't found it to be an issue, though they do get clean if you use them for something harsh like a nitric acid synth. Mostly it's just conc. sulfuric acid reactions/tar that end up making it black/brown
The way to mix a gas is to embody it inside a magnetic field. No gas will rest under a liquid in atmosphere very well. H+ in air (forming HNO oxide-group) causing N2 forming underneath is only effective under a slight magnetic field, in the presence of liquid argon (or another stable hydrogen-field reactant). You probably noticed the earth’s magnetic field depending your yield!
![Making [2.2.2]Cryptand: A Chemical Prison](/img/logo.svg){kind=logo}
