Making methylamine HCl but for legal reasons 

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Seeing the garage doors in the glassware really brings it all together.

that 'distillation' is one of the undergrad moments of all time

Psychedelics are just an exceptional mental health breakthrough. It's quite fascinating how effective they are against depression and anxiety. Saved my life.

27% yield is good without a proper schlenk line setup. In the world of inorganic synthesis thats a solid yield. All that smoke and fog is your hygroscopic reagents reacting with water lowering your yield. Nice work!

Excellent video! Now all I'm left to wonder is how the hell you got Brilliant to sponsor a List 1 precursor synth, lol. Great content, keep it up man!

this reminds me of taking chem in school. at the end of the year i realized my chem professor had taught the entire class about making meth. every unit focused around one of the steps of production for meth, but was focused on teaching the chemistry. he never acknowledged it and just laughed when i asked him about it later

Instead of using a funnel in the HCl try using a small glass tube. Bubbles would be smaller and provide more surface area for the gas to react.

when smelling something you should wave the smell over to you, that way if it knocks you out you don't fall on the lab gear. also you lower the amount that gets to you so the cancer probability is less. it was good that you did not hold the bottle.

The main reason these street drugs kill people purely has to do with them being illegal (as most deaths are caused by unknown purities and unknown other chemicals added to the drugs, as well as violence surrounding the illegal sales). The deaths involved almost never have to do with the pure form of the chemical itself, but a deranged, toxin filled shitty street version of the chemical. If these drugs were legal, and regulated, people would know the doses they were consuming, know the drugs were pure, and there would be far less violence associated with illegal sales and use. (Also less wasted on EMTs, less wasted on cops, less wasted on holding people in prisons for possession, all of this could go into free drug rehab centers instead) Decriminalization isn't enough, as it only solves half the issue, considering that people will always use drugs, they really need to be fully legalized and regulated. (Like cannabis, tobacco and alcohol) People don't truly care about deaths, harms and costs to taxpayers though, because if they did, it would be legal already, what people truly care about is the puritanical punishment of those they subjectively deem to be morally inept.

Just came across your channel while looking for an extraction tec for something totally different. And this is the best kind of chemistry videos on RU-vid man keep her up 🤘 got a lifetime subscription here today.

Always love seeing these uploads!

I used to work at chemical plant as an apprentice and I've never been more fascinated in my entire life! I was lucky to work up from a cleaner in just about 7 months, I'm not an idiot and I was obviously interested so they gave me a chance. I was lucky to work in a plant that was a "problem solver" so we there were only a few products that we did over repeatedly, one was refining oil for a Chinese company that was an anti-knocking compound. It was £1000/Ltr so we had to be careful. I didn't do any additions/reactions at that point, just dis/charging filters and drying in all sorts of impellor dryers and a kind of spin dryer. I loved it but my back gave out so had to quit. I really miss it, and could've punched myself for not doing better at school.

The easiest reaction is with formaldehyde combined with ammonium chloride and reflux it for a while. Make sure the ammonium chloride is in 2x molar excess and you will get nearly pure methylamine as your product with some ammonium chloride that will crystalize out of the concentrated methylamine. If you want dimethylamine instead simply use a 2:1 molar ratio of formaldehyde to ammonium chloride.

It's way better to use Tin powder instead of Tin pellets for that reaction.

Bro really pushing it with the government

SWIM says that the best way to get a good absorption with the "distillation" here is to use an aquarium bubbler stone, one of the big long ones, at the bottom of a jar mostly full of glass marbles or those weird ornamental glass pebbles they sell at craft stores. That breaks everything up into super small bubbles, generates plenty of turbulence, and slows the bubbles down enough to SIGNIFICANTLY increase yield. When SWIM was concentrating ammonia for making touch powder, that worked really well.

Very well put together very enjoyable to watch thank you

My dog, Jessie, woke up and walked over to me at the beginning of your video. She hasn't done that since I was watching the Bald Science Man show. 😂

Not sure if anyone ever told you this but if you are cooking spaghetti you should use a fish stone air bubbler it increases the surface area allowing more surface for the sauce to adhere to.

To increase the yield in the free base methylamine removal step you should try using a glass aquarium bubbler with a sintered septum inside a graduated cylinder (super cheap), or better still a proper gas scrab bottle.

Excellent production, Bravo Vince!

Love love love your videos!!

This is the kind of video needed by the world.

My new favorite chem channel!!

Thank you for this educational video. Beautifully simple steps and beginner friendly.

I know absolutely nothing about chemistry but i find it very interesting, especially this video. Looks like a lot is going on.

Love your vids bro!!

With Acetamide and the Hofmann rearrangement it is also possible to make methylamine, for the chloration you can use some kind of swimming pool chlorination agents

I have got a weird idea for better yield in bubbling the gas in the liquid, it seems like the gas doesn't have enough surface area reacting with the liquid. So why not use a aquarium air stone to make the bubbles smaller and thus making a lot more surface area? The stone should be mostly inert in most reactions.

The reason for the small yield and so much biproduct is while cooling the beaker it must be rotated slowly. Theoretically the liquid would just stay in the same position as the beaker spins but technically it’s turning into a solid so as it cools and becomes more dense it needs to roll away from the other chemicals it is separating from. Also quite a bit of the biproduct sitting on top can be purified and baked down for a less pure but much larger yield aside from what you already have, from what I saw looked to be about 2 to 4 grams but I didn’t pay attention to the measurements so not exact estimate. Hope that helps I was scrolling and was intrigued by some of the stuff you were doing and couldn’t help but check this one out. I was quite a good chemist until I got into a bad car accident, suffering brain damage but chemistry is still one of my favorite things.

Maybe you can use one of those stones which were used to bubble air into aquariums so the gas is finely spread when bubbling in the HCl. So you can get a bigger reaction surface and more product

Absolute madlad putting a Rhodium archive reference

I love thiis channel, at this point i just burst out laughing at each upload.

Dude your my new hero. Thanks

Pretty sure you could add to efficiency with using a larger diameter needle for bubbling the Methylamine into solution, you could also do that in multiple degassing stages

If I was you I would be quiet about being able to make that because you are pretty valuable if you can do it. I know a guy that claimed they brought five gallons of that to a plant he worked at. He said they had nothing else but guards and guns

i think there was a lot of Methylamine vapors escaping from your inverted funnel trap. May result in a higher yield to use a system with a fish tank air bubbler or simelar to increase contact area of the gas to the HCl.

Perhaps you'd get a higher yield if the bubbles of product spent a little more time in contact with the HCl solution, and if the bubbles had more surface area (were smaller bubbles).

you should be driving the methylamine by sparging the reaction mixture with a needle, with an inert carrier gas like N2 or argon, and the exhaust being cannulated into the receiving flask. basically: the reaction flask is sealed with a septum Ideally, gas is introduced into the septum sealed reaction flask using a long laboratory needle to pierce it (long enough to pierce the septum and descend all the way down to the reaction mixture so that the needle is partially submerged in the solution) You then connect this flask to the receiving flask with a cannula (a 12-24" long 2-ended stainless steel needle puncturing the septum of the reaction flask, but above the solution to allow the atmosphere in the flask to be pushed in passively, by the pressure from the in-bubbling N2) The other end of the cannula is submerged in the receiving flask acid, where the total system pressure from the inflowing gas will bubble out through the acid after first evolving the methylamine in the reaction flask. You can think of it like "degassing methylamine" in the same mechanism that you would "Degass oxygen" from a mildly oxygen sensitive reaction (For real oxygen sensitive reactions, you want to use "Freeze Pump Thaw", which requires a shallow dewar and a "hard vacuum" - which in O-chem means a "rough pump" like a Welch duo seal) in this way you would neither require a reduce atmosphere nor high heat to drive the methylamine out. Each little incremental element of introduced N2 or Ar contains zero partial pressure of methylamine, and the system will evolve metylamine from the solution to try to reach the equilibrium determined by the temperature and pressure..... This might not even be that much methylamine evolving for each small amount of gas, but the process is a "continuous flow" type, so even if each little differential mass flowed through the solution only causes a tiny amount of methylamine to come to equilibrium, the same process is repeated continuously until "all" of the mthylamine has been removed from the reaction mixture (in practice its very hard or impossible to quantitatively remove all of the methylamine in this way, but its by far the best method) in fact, there may even be a way to run this reaction in a continuous flow process. by constant addition of the reagents. Even if the reaction is never operated at conditions that would produce a high yield if it were operated in batch, the abilioty to continuously drive out produced methylamine would probably make it more economical. this is exactly the type of process that would be performed continuously in an industrial operation.

3:10 You sir have captured How I felt during my entire graduate chemistry career.

That was some decent stuff man 💯 nicefuly tasty

Boyyyyyy where are your goggles! In your reflection I couldn't see them 😂

Followed this procedure step by step in my kitchen using my hobs oven and microwave oven ,i allso have butane and some other stuff in pressurised cans. .im not sure what reaction i conjured up but ive just woke up on my front lawn ,all of my clothes have turned black,i can smell a gassy eggy smell ,my hair has gone....my ears are ringing and i can hear sirens.... Thoughts 🤔

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dude... you are a legit boss

The smell description actually made me laugh out loud

nicely done - not seen this method done before, the one that's more typically used is the 100+ year old, rather inefficient formaldehyde/ammonium chloride method I did have an idea for alternative workup step, based on an unrelated reaction involving amines I carried out recently: after the reaction is complete, remove as much of the solvent as possible, redissolve the residue in 25% caustic soda, extract your free-base methylamine with isopropyl alcohol (which is immiscible with highly concentrated salt solutions), then acidify the extract and dry it by vacuum distillation might be worth a punt (the reaction I used this for was the reduction of amino acids to their analogous alcohols, using sodium borohydride and iodine - I got the method from DOI 10.1021/jo00065a020) also, I was always under the impression that dissolving metal reductions were radical reactions, so that ionic mechanism raised an eyebrow for sure

You should TLC your reactions mixtures. This will give a great understanding of your product development. Also your final reaction for yield should be higher toughly

1:43 They were probably using powdered metal instead of beads, which would have much more surface area and react faster

For the bubbling into the HCl try a fish tank glass and ceramic co2 diffuser. The fine bubbles produced with increase surface are. Im not sure if there would be enough pressure though. Also cover the top of the beaker…

I think you can just use organic solvents such as DCM to get the methylamine out of the solution after adding NaOH, as the basic methylamine is soluble in DCM. And after separating the oraganic layer, just bubble some HCl gas into the DCM and you'll get Methylamine HCl salt precipitate out with better quality

What is that used for

Please can you help me. Ive been on prescribed diazepam for nearly a decade and it terrible. Thr doctor wont change it to anything else 😢 Could you please show me a way to get hold of these other alternatives. Thank-you

The white vapor forming upon the gas bubbling through the acid, is your Methylamine HCL salt. It looks a lot like the formation of ammonium chloride from NH3 and HCL. A lot of the microcrystalline salt escaped in the form of these fumes, so next time you may want to use a proper gas bubbler to catch the majority, as the funnel trap is highly ineffective here.

Low yield was probably a few things - purity of the starting chemicals, not completely or correctly reacting all the tin, and not having a fractional distillation apparatus. Great job Jesse!🔮🎱

What metal are you useing from what I understand silver is what is needed

Tip : Use more HCL to dissolve the methyl amine and increase the surface area of the funnel next time😅

Thank you I really needed that laugh 😂

Tin is really slow reacting in HCl. I'd have refluxed longer. Also the suggestion about the small tube instead of the funnel. Looks cool, glad it worked.

What exactly happens at 5:10 ? What are you adding there and if important, how much? TNX

I love that you arent weaing any PPE apart from gloves lmao

Is it possible to make a solution of 40% Methylamine and water with this Methylamine HCL?

اقا یه سوال... این آزمایش ازمایش چی بود. جای میشناسی که ساخت شیشه اموزش بد با درصد بالا در بیار

The wizardly swirl is the most fun part of being in a lab

min 6:05 im not realy sure what is that gas/vapor. BUT its probably methylamine hcl. before you turned the heating CHL from the hydrochloric acid escaped and went through the funnel and formed methylamine hcl! I hope that helped you!

That white smoke is methylammonium chloride aerosol. Similar think happens when gaseous ammonia reacts with HCl.

My dad used to cook in the 60s. His method I would assume was the one that used ephedrine or pseudoephedrine. That good ole biker crank lol

To gain higher yield(s) maybe try adding a solvent after the sodium hydroxide then stir wait about 15 minutes separate top solvent layer then do what you did in the end only your solvent will be getting the gas vapor from the acid and that should work oh yea make sure your gas vapor is dry with no moisture

THIS MAN IS ON *A LIST* I SWEAR TO GOD!

What is that white pill shape thing (much bigger than a pill, just using that for shape) What is that white capsule in the beaker right before he added the foil

Really cool video

so like at 4:22 after you made it cold why did you not decant or filter? is the tin and tin chloride useful perhaps you could go threw the reaction more so I understand. so like 5:47 the point to expose the gas to the liquid HCL so rather then a wide funnel how about a glass tube and a long tube to hold the liquid that way when it bubbles out it has a lot of liquid to travel threw, the gas will coat the inside walls of the bubble and as the bubble lifts up new liquid will replace those walls, if you wanted you could cap the liquid containing tube and run the gas coming off of that threw another tube of the liquid. some times you can find cheap gas filtration tubes sold as water pipes for smoking local herbs, depending on the state you are in these water pipes might be called "bongs". they are usually made from borosilicate glass as they are use to dealing with heat, so they should work as normal lab glass. perhaps the gas does not have enough pressure coming off of the reaction. I wonder if you could increase the pressure using a U pipe with the reaction mostly happening on one side of the U while every now and then you increase the pressure to the other side of the U to push a bubble threw, in a batch.

Could the loss be it was pushing over in puffs escaping without touching enough acid?

Do you think powder tin would be better?

The explaination I got for such reactions, is that the reaction of the metal with acid generates hydrogen gas in-situ. That's also called nascent hydrogen ("nascens" lat. "being born") and its more reactive, than plain hydrogen gas from a balloon, since it's in a higher energy state as it forms; it then directly gets consumed reacting with the nitro group. The complicated mechanism you showed likely also takes place in parallel and/or the metal acts as a catalyst aswell. It's a total mess :P

Dude is absolutely brilliant, even if the content is questionable.lmao😂😅🙏🏼🙏🏼🙏🏼

On March 18th of last year, my friend got some Molly. Did a bunch of lines. Then didn’t sleep for two days, and that’s when I realized what I had actually just done

I'm surprised the hcl solution didn't get sucked back up into the funnel and tube.

What about routing the gas into a separatory funnel filled with your hcl and h2o? Or maybe actually redo it with distilling it. Fun video though!

Cant wait for the "feds raided my house" vid.

Reflux longer, run through vacuum flask w/glass filter. Bring to basic , separate in flask.

The "thanks guys" pic is what really did it for me ☠️

Doing chemistry is like fighting omni man . I felt that punch dead ass

Great.. now I'm on yet ANOTHER list.

How does the inverse funnel setup compare with a tube with a small opening, deeper into the HCl solution, in regards to rate of reaction. Thinking about the surface area of small bubbles and the time it takes them to rise, compared to how the gas phase sits on top of the liquid phase in the reverse funnel and there isn't much mixing except for the occasional 'fart'.

useful tutorial

Isn’t it funny that the crude reaction mixture contained methylamine and HCl, but you had to neutralize it, distill it, and put it back in HCl to isolate it? Chemistry’s a pain sometimes. Just my two cents, but I might’ve re-checked the pH halfway through the distillation to make sure it hadn’t gone acidic. The wisps you saw on the hot side were probably MeNH3Cl, a bunch of which was left in the reaction flask. You might’ve been able to stir that stuff with NaOH and re-distill to pull out more methylamine.

Make a video making it like we used to back in the day. Put a few ounces of Coleman fluid in the bottle 3 tbsp of ammonia 2 tablespoon of lye 15 240mg Sudafed pills and one AA lithium battery in that bottle. Close the lid fast as possible and shake it like crazy

They have the recipe and instructions for this in the anarchist's cook book

I love chemistry, can u do 1 on taking out (extracting) the mitragynine and 7-OH-Mitragynine out of krarom "tea" powder,leaves.

Why it s not work direct with SnCl2?

The fumes are inpure methylamine, so are the coating of yellow in the middle of the reaction (of the flask!) is also impure methylamine IMHO..

Bro is really climbing up the wanted list

What is a stirbar?

Next time, try insulating the flask during reflux. That should keep the walls of the flask hot enough so that nothing can crystallise out on them. If it still happening a because you wanted to get a nice shot or whatever, you can give it a quick blast with a heat gun off camera. Reducing this built up may or may make your yields a little higher. This might have been what the paper was talking about when it said things could get out of hand, but I’m just speculating haha

i'd just make a setup to drip NaOH sol'n into the mix and have a line out to bubble thru ice bathed HCl sol'n. No losses to the atmosphere in between.

chemistry is so cool, sure wish i knew it

Jessie We need to obey the law

does the size of the pellets (tin) matter?????