MTHFR GENE MUTATION Symptoms and health conditions (MTHFR C677T & MTHFR A1298C)

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Interested in resolving depression and anxiety naturally?
Check out Dr Janelle’s online course Real Relief Foundations. www.drjanellesinclair.com/eco....
Download a copy of the MTHFR gene treatment report: www.drjanellesinclair.com/mthfr
MTHFR gene mutations are a very important topic for mental health. These MTHFR genetic mutations affect more than 57% of the population. The most common genetic SNPS are MTHFR C677T and MTHFR A1298C.
In this video Dr Janelle Sinclair discusses MTHFR gene mutation symptoms (MTHFR symptoms) and MTHFR indicators. MTHFR and depression, and MTHFR and anxiety will be covered. MTHFR is also very important for Schizophrenia, bipolar disorder, infertility, migraine, and Cardiovascular disease. She also talks about the biochemical consequences of a MTHFR mutation including enzyme activity for MTHFR homozygous C667T (MTHFR C6ttT mutation), MTHFR heterozygous C677T and MTHFR homozygous A1298C.
Here's a link to a review article on MTHFR genetic mutations and the associated diseases.
www.researchgate.net/profile/...
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*Dr Janelle Sinclair received her PhD in biochemistry from the University of Basel, Switzerland in 2003. Her use of "doctor" or "Dr." in relation to herself solely refers to that degree. Dr Janelle is a licensed natural health practitioner in New Zealand. The content contained in this video is strictly the opinion of Dr Janelle Sinclair, and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. It does not create a doctor-patient relationship between Dr Sinclair and you. Dr Janelle nor Conscious Health Ltd are not liable or responsible for any possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content should seek advice from a physician or qualified health provider with any questions you may have regarding a medical condition or interactions of supplements with medications. This description may contain affiliate links.

Опубликовано:

6 июл 2024

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Комментарии : 98

@DrJanelleSinclair 5 лет назад

Do you think this genetic weakness may be affecting you? Or have you had yours tested? Let me know what you found and whether compensating for the weakness benefited your health. I'd love to hear.

@robert12iosif35 4 года назад

Hei you from london?

@DrJanelleSinclair 4 года назад

@@robert12iosif35 no from New Zealand 👍

@cristinabereghi5625 3 года назад

Hi Dr Janelle. What is the different between taking folate or folic acid as supplement for MTHFR C677T homoz? Thank you

@DrJanelleSinclair 3 года назад

@@cristinabereghi5625 methylfolate is the supplement that you want to take. It's the active folate molecule. Folic acid is synthetic and has to be processed by the body. The mthfr genetic weakness means that you can't process the folic acid molecule well into the active methylfolate that the body needs.

@cristinabereghi5625 3 года назад

Dr Janelle Sinclair thank you for your reply. I read that taking folic acid might actually be problematic in case of this polymorphism, but I have not managed to find the reasoning for this. Could you please clarify? Highly appreciated.

@1258melody 3 года назад

Drs don't take this into consideration at all first time iv seen a doctor actually informed about this

@lms6137 3 года назад

Explains my lifelong battle with depression....heterozygous A and C....

@danithegal 5 лет назад

Thank you for breaking this down so well for us! ☺️👏

@psi-ops1397 3 года назад

my new best friend! Thanks for this. I checked out a few more of your videos relating to the same topic and have a feeling this is going to be life changing! Howdy from America (or what's left of it) :-P

@jeearr7082 3 года назад

My doctor did an MTHFR Genotype Analysis (Blood Test) and my results say C677T mutation Heterozygous and A1298C mutation Heterozygous. I looked it up and it ticked a lot of boxes regarding my health. Thankfully I made several lifestyle changes many years ago, but I will be watching your other videos to see what you recommend. Thanks for this explanation. I’ve started taking an activated B complex and it doesn’t make me vomit like I did when I took a B complex once (before I knew I had MTHFR) I don’t generally eat bread, but if I do, I stick to gluten free (home made), trying to cut back on coffee, I only drank 2 cups a day, but now down to 1, trying to eat more fruits and vegetables, particularly the greens, and add in more legumes. I only got my results a few months ago and so I’ve only really started my journey. Will let you know more about the health benefits as I know.

@vivienkittel3063 5 лет назад

Such important information made simple. Thanks Dr Janelle :-)

@DrJanelleSinclair 5 лет назад

Thanks Vivien!

@konstantinosb9566 4 года назад

Thanks for this video....you opened my eyes

@tiffanyguldi7564 3 года назад

My test came back as having an intermediate risk for the C677T. I was muscle tested for MORS by systemic formulas. I took my kids to get checked too and they also have it so I started them on supplements too:)

@moka100original2 3 года назад

Thank you sooo much.

@B1iss0ut 4 года назад

Thanks Janelle. I think I might have one of these gene variations, but am going to test to find out. My daughter was born with tongue and lip tie (which has caused us all sorts of problems), which is what prompted me to look into this further, as well as depression and bi-polar in our family. Also - totally not related, but I just wanted to say I love the blouse you are wearing in this video :)

@DrJanelleSinclair 4 года назад

Thanks Rachel. Where do you live? I agree that you should get your genetics tested. Great idea.

@B1iss0ut 4 года назад

@@DrJanelleSinclair I live in Auckland NZ. Have ordered the Ancestry DNA test to get raw data, then planning to look at Stratagene after watching one of your other videos.

@shannonrunge2080 5 лет назад

Love your simple explanation of the MTHFR mutations. I have one copy of each SNP and I've found that adding in folate-rich foods (beans, lentils, asparagus, greens, avocado, etc) has had the biggest impact on my mental focus and energy levels. Still working on finding a good Vitamin B supplement.

@DrJanelleSinclair 5 лет назад

Fantastic Shannon. I'll be doing a video next week on treatment considerations, so check that out.

@gypsierose3611 3 года назад

I always wondered why I craved beans. And all my health issues omg this has made my life make sense I no longer feel crazy

@alonmatthews7264 3 года назад

Thanx for sharing :)

@dvera6514 3 года назад

Love your videos! Do you have an eBook or anything of that sort about MTHFR?

@n.c.6211 3 года назад

This is the thing that is shouting at me, thank you so much for your precious info🙏🙏🙏

@josiahculley9877 3 года назад

I have it the best treatment for it is Metagenics - ceralin forte

@JAMESGREGORYKULP1985 3 года назад

I am 35 years old and I am on the Autism spectrum I have PDD-NOS. And I have a sacral dimple. And I am not sure if I have the MTHFR gene mutation. And I was planning on getting the covid-19 vaccination. But I have read that if I have the MTHFR gene mutation I should not take the covid-19 vaccination.

@Ssosophisticated 3 года назад

i have PMDD and i have 2 copies of the A1298C MTHFR, what kind of a dr should i be seeing?

@betmikael28 5 лет назад

Thanks for the clear explanation! I thought everyone has a tongue tie?

@DrJanelleSinclair 5 лет назад

Everyone has a small frenulum, but not everyone has a tongue tie.

@tundeannadioszegi4645 2 года назад

My sister is heterozygous for both mutations. I read that has the same effect as being homozygous.

@DrJanelleSinclair 2 года назад

Yes you are right

@Holisticenergyhealings 3 года назад

Dr. Janelle, I have both mutations as well as Ehlers Danlos Syndrome. Do you find a connection between these genetic mutations? Of the EDS & MTHFR mutations?

@mspomeroyproductions Год назад

This is a great question for which I’m also curious about. I have hypermobile EDS and tested positive for heterozygous 677 snip. Lots of symptoms.

@susiewilliams6981 4 года назад

i have 1 copy of each and have stuggled with health issues my whole life. Intese depression when I was a teen and extreme IBS for as long as I can remember, specifically an intolerance to sulfur rich foods. Acne and folliculitis and now PCOS and hypothyroid

@jamielynns6825 4 года назад

Me too! I have one copy of both and have had hypothyroidism for most my life 🥺

@garethharkness1823 3 года назад

Hi I recently got tested and have a homozygous mutation (tt) mao a r297r along with a homozygous mutation on mthfr a1298c. What would you recommend in using to treat these? Thanks!

@LolaSmollz126 3 года назад

What was the test called? Is it just lab draw?

@rumble5557 3 года назад

But what is you have the CB6677 homozygous and you also have the upregulation for sulfur. So I would love to get more folate in my diet for my mutation but I friggin can't because of my upregulation with sulfur dumping. What am I to do? This is a serious problem for me. Causes terrible fatigue and anxiety. I've tried reccomended B supplements too like P5P and they make me feel like I'm losing my mind.

@rolarola9134 2 года назад

Que tal

@BoxOfShockolates 2 месяца назад

Hello, do you know if the C677T variant is sometimes linked to ADHD?

@OoOo-qz3fn 3 года назад

I have mtfr a1298,c snd and other 5mutations of THROMBOPHILIA test . always i felt tired after i ate some foods but recently i started feeling really bad when i eat some foods i have headache and and deasy .i can't walk straight and i can't breathe with beans and artichoke after 3-4hours i ate them.IS THAT ABOUT the folate is in these foods snd and i need to take felicine which is methylation?

@OoOo-qz3fn 3 года назад

My mutations is c.1298A>C eterozygos

@Truerealism747 Год назад

Never new about tongue Tye's got top and bottom fybromyalgia symptoms OCD from birth hope u can reverse

@nadinesokie9 4 года назад

Dr. Sinclair I have 677T and A1298C I had 23 and me . +and - on both of these genes. Should I supplement with these.

@DrJanelleSinclair 4 года назад

Have you checked out my free report on the topic? Please read that and then if you have any questions feel free to ask. www.drjanellesinclair.com/mthfr

@jasonmaurer6714 4 года назад

I have acid reflux and 677T mutation. I quit gluten and dairy but i still get it at the moment ugh

@tundeannadioszegi4645 2 года назад

I have the same mutation and also have problems with digestion.

@TayDaley Год назад

Try cutting out carbonated beverages and spicy foods doing that for me has worked. Dairy makes no difference

@outingsforoldladieswhoaren7664 4 месяца назад

Well, how do I know what I am? What tests should I ask my doctor to order? I have chronic fatigue and fibromyalgia. I am sooo sick and tired of being sick.

@tornadoe505 3 месяца назад

In the US my dr got me the Genomind test. You can google them thats how i found out. Not sure if there is other blood work you can do. Im in a similar boat to you. Good luck.

@scottfleetwood1991 2 года назад

What if you have one copy of both genes? Is there a synergistic affect?

@DrJanelleSinclair 2 года назад

Yes. Check out my comprehensive report www.drjanellesinclair.com/mthfr for more info

@neurologicalworms 4 месяца назад

So many people creating RU-vid content about MTHFR mutation , they're basically saying that the mutation is a load of nonsense. That its all hype and nothing beyond. Noone here is stating this , but I am just going to rant. My pregnancies were tough and this is what led me to finding out I had this mutation. My babies had severe inner uterine growth restrictions due to my mthfr and factor 5. It really scared me , esp with my first. She was born at 33 weeks , 3 lbs 2 oz. I would not wish for any new momma to get the surprise at 3rd trimester that their baby is not growing right for unknown reasons and to prepare for NICU. They could not even assure me that She would be stable after delivery. I was told to also prepare that she may need to be immediately taken to receive proper attention. I thought I did something wrong and blamed myself so i isolated so to avoid sharing this news with friends. I thought the worst , that It was like i had killed her somehow. Its stupid sad saying it even now. . I know so many wonderful woman have to grief much deeper losses in their pregnancy / delivery stories.... I recognize I was nothing but blessed and i definitely dont intend to victimize mysellf. It is just that to say mthfr is essentially NOTHING is realy ignorant. It clearly isnt nothing. . . I also do believe this may be why i have such chronic depression. Im here to learn more about it and plan to test my daughters for it too, as it might be a big factor to understanding & supportung them properly.

@yma1233 2 года назад

What do you do for your babies/toddlers who inherited the MTHFR CC gene? I feel so guilty 😫 How do you compensate for young children?

@DrJanelleSinclair 2 года назад

There's no reason to feel bad. You can't change your babies genetics and you didn't make them that way. You are an awesome mum for caring. You can give your child a small amount of b12 and folate or a child's multivitamin to help. 💕

@yma1233 2 года назад

@@DrJanelleSinclair Thank you so much!

@bernadettejones2491 2 года назад

@@DrJanelleSinclair my gp put me on 5mg of folic acid I was on it for 5 years does mthfr effect b12 as well I've got numb tingly toes and fingers do the same I feel ill I take sublingual b12 liquid I still feel ill thanks

@fergfergable 4 года назад

You've probably answered this somewhere else, but how do I find out if I have that mutation? 23andME?

@DrJanelleSinclair 4 года назад

Yes 23andme or ancestryDNA testing

@fergfergable 4 года назад

Ok! I did call 23andMe after I messaged you but they said they don’t? Maybe I’ll try ancestry. AnyLabNow is a company in my area and they do it for$150.

@DrJanelleSinclair 4 года назад

@@fergfergable ancestry DNA will give you DNA data on a large number of genes like comt. It's unlikely that your local lab will do more than 1 or 2 genes for that price

@fergfergable 4 года назад

Thank you so much Dr Janelle :) so glad I found your channel!!

@DrJanelleSinclair 4 года назад

@@fergfergable my pleasure. Glad you found me ♥️

@profile_01 2 года назад

So prior to synthetic folic acid being put in foods and supplements , having the MTHFR mutation was absolutely no different from everyone else, because there was no folic acid and everyone needs natural folate anyway? Isnt it more like a modern folic acid disorder then?

@tundeannadioszegi4645 2 года назад

Well people were not getting enough folate then either bc. It is difficult to get it all from the diet.

@toni5543 2 года назад

It's like egg and chicken. What came first. The inability to use foliate or thwack of foliate made us loose the ability to use it?

@sarahcouture1202 4 года назад

Im so confused! So my data says my genotype for C667T is A/A. What does this mean?? Please help!

@DrJanelleSinclair 4 года назад

A and T are sometimes used interchangeably. your code isn't C or G right? TT means you have two copies of the "mutation". This should help www.selfdecode.com/gene/mthfr/

@kimdecovich1198 4 года назад

@@DrJanelleSinclair so if I have wild-type (C/C) for the MTHFR C677T, what does that mean? I'm confused too. Thanks :)

@tundeannadioszegi4645 2 года назад

@@kimdecovich1198 the wild type cc is the normal type, no mutation.

@saulostucky1461 3 года назад

Should I take folic acid and folate or just folate if I have MTHFR? Thanks

@DrJanelleSinclair 3 года назад

Avoid folate. Ideally take methylfolate/mthf. Folinic acid is okay if you don't tolerate methylfolate/mthf.

@naniahmed6835 3 года назад

I have mthfr mutation heterozygous c677t Factor v leiden mutation heterozygous Should i take folic acid or folate

@rayellejohnson9961 3 года назад

I’m confused. I thought they said to avoid artificial/inactivated folic acid

@fionastaats6249 3 года назад

It would be nice if you could the percentages for people that are compound heterozygous. I was tested back in 2004 after 2 fetal demises. I have followed the research as they have discovered more. People that are new to finding out may not realize that being compound heterozygous is considered as serve if not more than homozygous because yellow on both charts doesn’t look bad.

@nachiketa3629 Год назад

Hi Doctor, are there any links to vaccinations and this mutation?

@jakesanin1 2 года назад

We allready know what that is we need cure,people are suffering but nobody is doing anything

@DrJanelleSinclair 2 года назад

Maybe watch my second video then 😊 it's all about how to address it

@renatabazzani1987 2 года назад

Perché non parlate in italiano

@phxman7519 4 года назад

I have a question for you. I am a 44 year old man who had sex with a woman a few days ago. I pre-ejaculated as I have erectile dysfunction from type 2 diabetes and came within seconds of me being inserted into her. I know that it is a slight chance of getting a woman pregnant from pre-ejaculation as I read online, but I know it is still possible. I also have a major blood clotting disorder where I am homozygous for MTHFR and heterozygous for Factor V Leiden. I have had multiple clots to my leg and my lungs and am on Warfarin for life for which it is a high dosage. The woman I was with has no clotting disorders that she is aware of. Based on my clotting disorder alone would a woman have success with a pregnancy?

@hepthegreat4005 3 года назад

can the woman get pregnant if you have a blood clotting disorder? yes. she doesnt have the disorder and your semen isnt in blood.

@tamfx2138 3 года назад

@@hepthegreat4005 Is she pregnant?

@samezzieni4750 3 года назад

WHICH MEDICAL SCHOOL YOU ARE GRADUATED FROM ?

@DrJanelleSinclair 3 года назад

As I said I'm not a medical doctor. I am a doctor of biochemistry (PhD) and been working in the natural medicine field for over 15 years. My doctorate was from the Basel University in Switzerland.