Purdue University Professor Arun Ghosh talks about his research in designing enzyme inhibitors for the treatment of AIDS.
Dr. Ghosh received the 2010 IUPAC-Richter Prize award in recognition of his outstanding use of structure-based design of HIV-1 protease inhibitors using his novel concept of “backbone binding” to withstand drug resistance.
This work produced the novel drug Darunavir which was approved by the FDA in 2006 as the first treatment for multidrug resistant HIV. He has also pioneered structure- based design of β-secretase inhibitors for treatment of Alzheimer’s disease.
13 ноя 2022
