Scientist on how topical supplement ‘reverses aging’ on our skin | Interview with OneSkin founder 

I hear you. I think the prices are particularly high on these more innovative products because of the R&D involved. Hopefully they come down in price (relative to inflation!) over time.

@@thehonestchannel ❤

it's not that, it's probably the Decapeptide-52

@@thehonestchannel Hopefully, I love your channel by the way. Definitely the best out here!

@@NavilleT Decapeptide-52 is there mostly for pigmentation I believe, The oils are the highest in the ingredient list with means it makes up the majority of % on each bottle, water being the number one on the list. Even though peptides are fancy is just not enough of it on each bottle to justify the price for the amount you are getting. I think the product is probably lovely but not worth more than $65 -$75 and that is way up here already.

Thanks Lorena! That’s great to hear ❤️

Thanks for sharing your experience, Ida. My mum loves the OneSkin moisturizer but you're not the first to say they didn't see a benefit. Six months is definitely enough time to try a new treatment out.

I agree!

That’s interesting to hear - thanks for sharing your experience with us.

Thanks Sophie!

Thanks Claudia! I noticed you're a fan. Good to know you enjoy using it!

Hw do you know it's this that is making a difference; how are you trialling it to ensure this is the thing resulting in improvement? He are you objectively measuring improvement ?

@@carolenmarch7445 I was using everything else for a minimum of 3 months before I began. I had ALSO already done prolonged fasting with hit and run doses of grape seed extract and fisetin. When I started OneSkin, I got improvement specifically in the slight laxity that I had before. I'll do PRF in a year or two rather than adipeau, which doesn't impress me, but this does. I have better results with Dr Pen and peels using One Skin, too.

Great to hear! My mum is also loving it

What changes have you seen, because I have used this product for 3 months & see absolutely nothing, unfortunately, but then again, I'm 75..

@@valentina-pg4bj The change I have noticed is that my skin isn't dry anymore, I hardley ever use face cream anymore. I live in Canada and the humidity is so low. This is the first year I didn't even bother with the bedroom humidifier. I have also noticed a very very slight improvement in my wrinkles but definitely not a big change. The sagging skin hasn't changed. I am hopeful that the longer I use it I will notice more changes. Take care.

@@bekind4329 Thank you for taking the time to respond, & I also use a humidifier in my bedroom every night because I live in the Arizona desert. I would continue to use OneSkin if they lowered their prices now that they are shipping a replaceable pouch for your container. So for me to pay $99 a month is just too much in my opinion, unless I saw a significant difference; which at this point I don't. Thank you kindly!

@@valentina-pg4bj You are welcome. I totally agree I wish they would lower their price. My bottle lasts around 2 months and even that is expensive, plus the exchange rate for me makes it even more expensive.

That’s great to hear. Thanks for sharing your experience

🤣

Hopefully we see the pricing of these innovative new skincare products become more accessible over time.

Thanks for sharing your experience Angela!

Hi Susan. So glad you find the videos helpful. I’ve included a link with discount code on the video description if you click ‘show more’ on the text box just underneath the video. Unfortunately they don’t deliver outside the US and Canada at the moment but I will update as and when that changes.

@@thehonestchannel ok thanks Clare ..

Me too Pina. Think I’ll see how I go with the Adipeau first but I’m also interested in trying this out.

Do you like Adipeau?

@@Lulu-kt6gr So far so good but I’m giving it a full 12 weeks of use before I take a view on the results. I’ll share that update in December.

@@Lulu-kt6gr pretty good it’s only a few wks so I don’t notice any changes. It smells wonderful & feels very rich but not thick or heavy.

I was interested in the Adipeau, too. The before and after photos didn't impress me enough to try it. I'm eager to hear about your experience!

Thanks Linda. ‘Clean’ is definitely one of those buzzwords right now!

That also somehow ticked me off. I suddenly found myself at odds with the data, these women are throwing at us. They are now trying to get on the "Droplet" device. As oppsed to getting more data, and pushing their discovery,. Something stinks.This made me think, this is just BASIC skincare. The buzzword like "CLEAN' (being used up and down the Isle of the beauty industry), I want them to define this term, as Im tired of hearing this word bandied about like its some major find, but really it's for "Virtue Points" to push the brand, as "Clean Beauty" has MAJOR problems, in itself.

@Linda Joy Agreed. She lost me at “San Francisco” based. I am immediately skeptical. (But so far love the content of this channel).

Hi Chris. Sorry, I should have checked that. I've updated the link in the description now.

They have sent me a face cream to try so I will try to fit it in at some point. Be interested to hear what you think of it. I think Claudia is a fan.

Hi Amanda. I’m waiting to hear back from OneSkin about when they’ll deliver more widely. I’m in the UK and would also like to be able to order it. I’ll update when I hear more.

I’ll make a note of it. Thanks for the suggestion!

Great suggestion, thanks.

Hi. I'll find out for you and let you know.

Yes, I hope they'll be able to ship internationally before too long.

Hi Donna. There's advice on how to incorporate OneSkin products into your routine in the FAQ area on the site. This is what it says: At their core, our Topical Supplements are moisturizers, so we recommend applying them after cleansing and before sunscreen. OS-01 FACE and OS-01 BODY have not been shown to produce adverse reactions with other products and ingredients, including retinol, vitamin C, and hyaluronic acid. This means that you can safely incorporate them into your current routine without any additional changes. To learn more about how to integrate OneSkin into your current routine,

They don’t seem to be available outside North America at the moment but I am waiting to hear back on when that might change. I’ll update when I know more.

Hi Christina. I'll find out for you. I'd also like to start using this product.

@@thehonestchannel Also interested :) I am based in Germany. Thank you

That's really interesting to hear. Thanks for sharing your experience. My 80-year-old mum is using the face cream at the moment. I thought she would make an interesting test case!!

I'm 66 and figured Id be a great test case too! I'm looking forward to hearing your mum's experience. So far, no product that Ive tried, even 1% retinol nightly, has diminished a single line, despite a healthful diet and good habits. Vitamin C and BHA have both made skin softer and brighter, but that's it. I found the oneskin hype to be suspicious. When i emailed to unquire anout using the product with Vitamin C or other serums, the answer was so vague as to be useless. It was basically advice to do whatever i thought worked. When i asked what ingredients in their cleanser made it different and more effective than other cleansers, the response was commercial advertisement for what the product purported to do, but not an answer as to why it was better. Guess i can't expect much. I'm still waiting for more reviews with the same lighting and clinical studies. As mentioned, in vitro is not the same as in vivo.

@@honeysucklewoes1627 They answered my questions, giving the specific pH it's stable to. Don't use it with ascorbic acid.

@@toomanymarys7355 Thank you! So do you think that waiting about 20 min after applying CE Ferulic, or until it's no longer tacky, would be sufficient?

I know exactly what you mean. NMN is the main one but it has recently been banned as a dietary supplement in the US. I take Tru Niagen every other day. I only recently started taking it and it’s pretty expensive but is the most evidenced. That and high strength vitamin D.

Yeah I agree trancedimi. Getting to the truth is bloody exhausting alright. You really have to be persistent to get to the bottom of it. It can be very confusing, especially you're not awesome at interpreting the data/findings. Even the experts don't know half the time I reckon... haha.

Curently in aesthetic pharmacy we are talking a lot about Pinus Pinaster extract and Polipodium Leucotomos extracts.

Nmn, collagen type 1 and 3, Omega 3, glycine. Diet wise: the anti inflammatory diet that is lower carbohydrate to ensure stability of blood sugar. Avoiding alcohol, fried food and processed food. Time restricted eating also seems highly effective.

That sounds like a good approach because the Adipeau isn’t as effective on the forehead and temples but seems to work better under the eyes and on the cheeks and jowls. Is it the OneSkin code you’re having trouble with or Adipeau? The OneSkin code only works on one-off orders rather than subscription.

@@thehonestchannel The Adipeau one worked. It was the OneSkin that didn't. Probably because I first did for subscribe, then switched to one off. Cookies probably made it still not work.

@@consciouscrypto3090 Shame you didn’t get the discount!

Have you seen good results with it?

Would love to hear your thoughts on your experience, please.

I have asked the question - still waiting for a response but I'll update as soon as I have one.

The supplement does contain hyaluronic acid so if that's something that causes breakouts I couldn't say whether this product would be any different I'm afraid.

You could try Adipeau, it doesn’t contain HA. Watch Clare’s interview with Ivan from Adipeau, I was convinced enough to try it and am seeing some improvements in my skin. Also ships worldwide and not outrageously expensive

@@lindajoy23 Great to hear you’re seeing results with the Adipeau Linda. Hopefully the discount codes help a bit with costs too.

@@thehonestchannel Thanks Clare, I used the discount code on my first purchase and received a complimentary bottle with a lovely letter from Ivan. I’ve since purchased another bottle to have a back up but forgot to use your code 🙄

Isn’t it great?

Thanks so much for sharing your experience Courtney. What kind of difference to your skin have you seen with OneSkin?

Did you trial this desperately, or did you use in tandem with retin A?

Then it seems it would be a good option for those who can’t handle using retin A.

@@stacyrlee of you largely want to waste your money , yes. Better option if you can't handle retin A , but with proven efficacy is Tazarotene cream 0.1%.

@@thehonestchannel less texture for sure. Still prefer my dermatica though more firming.

It’s an absolute maze isn’t it. The jury is out on face exercises in that they can cause you to lose volume due to reduced facial fat. A dermaroller is a good idea, along with a retinoid, vitamin c serum and sunscreen. Less is more!

No. In their models they did not include fat cells.

Fat loss is probably the worst thing that can happen. I would suggest to look for volumizing bio stimulatory that are approved for fat loss in HIV positive patients like Hyperdiluted Radiesse and Sculptra.

there is a product and she did an interview with the D Scientist who invented it so llook back at playlist

It can’t penetrate unless you micro needle it it it won’t penetrate period

@@seascape185 yes apparenty some peptides work to signal cells to work better as a cascade effect but not by penetrating into the fibroblast

Hi Mary. Welcome to the channel! I’m delighted to have you as a subscriber. I promise I will share an update next month with my results. In the comments section of the first interview with Ivan some viewers are starting to share their experiences of using the cream and it’s sounding pretty positive!

@@thehonestchannel I can’t wait for the result I !! am 52 and going through menopause I start losing a lot of fat in my cheeks and under my eye actually all over my face at the same time I have saggy Joel to I don’t want to do any fillers I just want things natural so I hope it will work 😊🥰thank you so much and God bless you🙏🏻🙏🏻💕🌺

Not yet Marleen, though I would like to try out the topical supplements after using Adipeau for 12 weeks.

@@thehonestchannel Yes I'm very curious about you're Adipeau testing for 12 weeks.

@@marleenscholte2738 Not too long to wait now! There are a few viewers who’ve been using it who have started to leave feedback in the comments of the first video. Seems positive

@@thehonestchannel ooh I will look up the comments and wait for yours, on top of that they don't send to the Netherlands yet

Sorry to hear this but thanks for sharing your experience.

It's a good point, but while I agree that most skincare creams are unlikely to penetrate the stratum corneum I think there is good evidence to suggest some ingredients (including peptides) can and indeed do penetrate the skin barrier.

@@AFndjdj7373 Agreed.

Sorry for the late reply. I've just updated it now - apologies about that. glnk.io/0my3l/honestclare

Oh dear. It’s been working fine so far. It can only be used once per customer and on one-time purchases but I can ask OneSkin to check it out. Sorry about that.

@@thehonestchannel I see what the problem is. I was trying to become a subscriber and get the additional discount. Okay. Thanks anyway.

@@wadenyoost1796 No problem!

Great tip. Do you use the body cream for your face? My mum loves this stuff.

@@thehonestchannel I use body cream everywhere but face.

Not that I can see on their website!

Hmm. I believe the research behind this product is genuine, but it is very off-putting when reviews sound cooked. Thanks for flagging.

Thank you!

The key active ingredient that she discusses in the video is their proprietary peptide. On their site under the product listings they include details of six other supporting active ingredients including oleic pau mulato extract, niacinamide, pracaxi and andiroba oil. I would have liked to have drilled into the ingredients a little more with Carolina but her time was limited.

I assume it would be mitochondria-encoded peptides humanin, MOTS-c, SHLP2 and SHLP6. www.ncbi.nlm.nih.gov/pmc/articles/PMC6046248/ Cellular senescence is a complex cell fate response that is thought to underlie several age-related pathologies. Despite a loss of proliferative potential, senescent cells are metabolically active and produce energy-consuming effectors, including senescence-associated secretory phenotypes (SASPs). Mitochondria play crucial roles in energy production and cellular signaling, but the key features of mitochondrial physiology and particularly of mitochondria-derived peptides (MDPs), remain underexplored in senescence responses. Here, we used primary human fibroblasts made senescent by replicative exhaustion, doxorubicin or hydrogen peroxide treatment, and examined the number of mitochondria and the levels of mitochondrial respiration, mitochondrial DNA methylation and the mitochondria-encoded peptides humanin, MOTS-c, SHLP2 and SHLP6. Senescent cells showed increased numbers of mitochondria and higher levels of mitochondrial respiration, variable changes in mitochondrial DNA methylation, and elevated levels of humanin and MOTS-c. Humanin and MOTS-c administration modestly increased mitochondrial respiration and selected components of the SASP in doxorubicin-induced senescent cells partially via JAK pathway. Targeting metabolism in senescence cells is an important strategy to reduce SASP production for eliminating the deleterious effects of senescence. These results provide insight into the role of MDPs in mitochondrial energetics and the production of SASP components by senescent cells.

The oils must just be a carrier base - as it is impossible for an oil molecule to penetrate the skin - on top of the skin will Give the outside cuticle of the skin a softer feel - they do not penetrate - very unusual that she should use an oil base for a Peptide - it is interesting that a lot of the skin care companies now Are not hiding their active ingredients - they are Openly discussing it with their intelligent consumers - as consumers not only wants to know about the active ingredients - which are protected by patent - they also want to know about quantities that the cream contains of the active ingredient - example the ordinary company - they have multi peptide serums - and they’re happy to discuss all of their ingredients - they have informed consumers - No fancy advertising or packaging and keeping peptides very low priced

@@magickmagazine7675 I appreciate your insight. Thank you.

Thanks for sharing your experience, Theresa. It’s helpful to hear.

That's disappointing, but thank you for sharing your experience.

@@thehonestchannel I have to add that they never published my bad review on their website (i tried twice and was very polite, just saying: "no results for me"), and if you check, their pictures "before-after" are alwyas taken with a different angle, so for me it's a scam.

Sorry to hear it’s not worked out for you and thanks for sharing you experience with this product.

Really sorry this didn't work out for you. In years to come we will be able to buy peptide-based creams and serums that are formulated according to the types of peptides our skin particularly lacks and could benefit from replacing. At the moment though, we have no way of analyzing that and therefore telling which peptides are best suited to our skin. It means someone like my mum can see great results with a product like this and another person zero. Frustrating, I know.

Not paid, just interested.

Well number 1 I'm a journalist of over 25 years experience and I'm not going to invite someone onto my channel whose business I have not researched. Number 2, the article is totally related. If you read it there's a section in which the doctor is asked about any interesting research in skin aging that she's particularly excited about and she talks about OneSkin's work.

@@thehonestchannel Well Iam sorry pls provide the text in the FORBES article where OneSkin is mentioned. Also Dr Sinclair is unrelated also Tony Robbins is unrelated the others are Business Promoters. Number of Employee Profiles 4. 4 Phds ? Anybody can be a Phd in the US I am a Phd in religious science bought it for 50 $ Took me 4 min to find out this is are 4 people trying to get some cash this is no company with R&D or anything.

@@SheikhAlladeen Copied and pasted from the Forbes article: Is there any interesting research in skin aging that you are particularly excited about? I am very interested in the translational science being conducted by a couple of groups who are focusing on the role of senescent cells in skin and how this can be targeted to reduce inflammation and slow the aging process. One group is Oneskin - the CSO, Alessandra Zonari presented their initial data at the Science of Aging last year. They are a team of four female scientists who have identified a peptide and generated ex vivo data suggesting that it reduces the accumulation of DNA damage and prevents cellular senescence.

@@SheikhAlladeen And on the other two points. OneSkin is discussed in the Dr Sinclair podcast that is linked. I'd recommend you listen to it because it's highly informative. The Tony Robbins link is to his book which I've not read but am presuming they're in it which is why they've linked it.

@@thehonestchannel wow it took me one hour to find it among 100 others mentioned..I am very interested... who have identified a peptide and generated ex vivo data .Great good luck hope Tony Robbins and Dr Sinclair really talk about them one day.OneSkin operates end-to-end R&D in-house with a team of experts in stem cell biology, skin regeneration, tissue engineering, biochemistry, bioinformatics, molecular biology, immunology and aging. They measure skinspan in with MolClock - OneSkin’s first skin-specific molecular clock - and with skin aging modelling, using a proprietary technology and lab process which includes growing 3D human skin weekly and measuring how various products and ingredients influence gene expression of the many genes associated with aging and Longevity.Number of Employee 4 super human

I always appreciate honesty 😁 I turn 50 in February and i’m happy with the way I look. If I look my age that’s great - because I feel vital and energised. I’m not chasing eternal youth and I’m not interested in surgery. I want to live, look and feel well for as long as I can. That’s it.

@@thehonestchannel well you obviously are trying to look youthful that’s why you spend money and make videos on multiple procedures 🙄. If you want real life results which will knock years off you I suggest you save money towards a deep plane facelift by an excellent surgeon. Do research on RealSelf and go for multiple in person consultations. These non invasive treatments are very expensive and produce no or minimal results and in some cases like with Ultherapy they can have horrible consequences. Also I guarantee your channel will get much larger if you made videos documenting your surgical journey.

@@wulfsorenson8859 I’m happy with how I look for my age and enjoy exploring skincare innovations. I don’t want or need surgery but I appreciate your point of view.

@@thehonestchannel I actually had a facelift. Wish it was a deep-plane one though, as I learned it wasn't. I do look about ten years younger but not just like I looked ten years ago. There are other reasons we look old, not just wrinkled skin. What about bone loss? The orbital area gets larger, and the bone's density decreases.

@@lynne4406 Absolutely. Aging well has to be a whole-body approach, not just skincare.

To be fair, this shows results from a body lotion in a case of pretty advanced aging. But the reason I interviewed Carolina is because I think products like hers point to the future direction of skincare and I find that fascinating.