OMG, this content is extremelly good, and god bless you for having so good pronunciation, and I don´t know if are you the ones who add the subtitles or some kind of youtube ai, but this allows non-native english speakers -like me- to understand it all
Im actually about to start my phd studies regarding the structural biology of the replisome of yeast, this really helped me to get a better understanding of thr field.
I still like to know how this stops at the telomeres, why half-holliday structures don't form, how evolving mutations assembled all this stuff, what is this likely to from next or how do we know this replisome hasn't already been extended/deleted somewhere, a better theory for emerging (enzymatic action) complexity and how these emergent complexities are pruned.... or is this where new medicine plays in.
Is there someone who can say me how does the loop after helicase(or before) action occurs? And moreover how helicase influence topologically the rest of strands(in other term, the next topoisomerase action). Primer is synthetisized after loop formation or before?
