This will be an overview on how Glucagon like peptide-1 receptor agonists and alcohol interact.
First, it's important to understand how GLP-1RAs work. They work on the body in 3 ways. They work on the pancreas to create a sustained release of insulin. They work on the gastrointenstinal tract by slowing down gastric emptying. They work on the brain to tamp down cravings.
Secondly, let's talk about some obvious attributes of alcohol. We've all said, done, or eaten things we shouldn't have when under the influence of alcohol. This is because alcohol lowers your inhibitions. Alcohol can also influence blood sugar. Lastly, alcohol is almost always consumed as a liquid.
Now that we understand these basic tenants about GLP-1RAs and Alcohol, let's discuss how they interact.
First, GLP-1RAs work with weight loss by making it easier to maintain a calorie deficit. If you're doing one drug that eases the burden of a calorie deficit, and another drug where your lowered inhibitions may make it easier to eat in a calorie surplus, you're battling the medication in a way that may push you outside of a calorie deficit.
Secondly, alcohol can influence glucose metabolism. This, paired with a drug that also influences glucose metabolism could be potentially dangerous, or at the very least, may influence cravings.
Lastly, alcohol, since it's usually consumed as a liquid is bypassing a benchmark for satiety (namely, chewing).
An interesting side note is that GLP-1RAs can also influence the amount of alcohol you consume. There are researchers studying the implementation of GLP-1RAs to help with alcohol use disorder. This is outside of the scope of this video. However, my point still stands that GLP-1RAs and alcohol may mix in a detrimental way when it comes to weight loss.
Overall I find people who consume a significant amount of alcohol do not get the same weight-loss effects as people who take GLP-1RAs and drink alcohol sparingly.
00:00 - Disclaimer
00:30 - History of GLP-1RA
03:40 - Alcohol
04:50 - Speculation on Interaction
09:43 - Steel Health and Hormones Centre
Steelhealthandhormonescentre.com
25 июл 2024
