Epstein Barr Virus (EBV) Part 2 of 4: Serology 

Dr. Been reviews the serology of the Epstein Barr Virus (EBV). EBV causes Infectious Mononucleosis. This disease is usually benign and self limiting. However, in some cases it can become chronic, or reactivating. EBV can also cause cancers and other serious complications.
DrBeen: Medical Education Online
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Original video from Dr. Been posted in August 2021
About infectious Mononucleosis
www.ncbi.nlm.n...
CDC on EBV Serology
www.cdc.gov/ep...
Serological diagnosis of Epstein-Barr virus infection: Problems and solutions
www.ncbi.nlm.n...
The Relationship Between Environmental Factors and the Profile of Epstein-Barr Virus Antibodies in the Lytic and Latent Infection Periods in Healthy Populations from Endemic and Non-Endemic Nasopharyngeal Carcinoma Areas in China
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Epstein-Barr virus (EBV), Infectious Mononucleosis
labpedia.net/e...
High level overview of the serologyStates of a person:Susceptible to EBV (never had it before.)No antibodies
Acute infectionVCA IgM
Acute infection late acuteVCA-IgM and increasing VCA-IgG
Past infectionVCA-IgG and EBNA-1 IgG
Reactivation of the EBV
www.ncbi.nlm.n...
EA (D) IgG
Increasing VCA-IgGDecreasing EBNA-1 IgGEven VCA-IgM may reappear during the reactivation
Immunosuppressed may haveOnly EBVCA IgG without EBVCA IgM or EBNA-1
In 1.7% of the infected patients may only show EBNA-1 without EBVCA-IgG (this pattern is usually thought to be implausible.)
Antibody patterns and causes from LabPedia
labpedia.net/e...
Disclaimer:This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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