Dr. Bruce Ames was talking about ergothioneine decades ago! He has a list of the most important compounds for health out there. Taurine was on there too.
Mice have approximately 97.5% of their working DNA in common with humans.........so you should not imply that you need to be a mouse to gain any benefit from this research
Don't black and red beans also have ergothioneine? I eat a ton of those. I only eat mushrooms like once a week or so. Maybe I need to eat more and look for these varieties.
@@rescuebabybirds Interesting, thank you very much!... "High levels of ET (up to 0.8 mg per g dry mass) were measured in cyanobacteria preparations sold as dietary supplements for humans and in fresh Scytonema and Oscillatoria cultures. Cyanobacteria contained as much ET as King Oyster mushrooms (Pleurotus eryngii). [...] Spirulina is a novel, safe, accessible, and affordable source of ergothioneine for humans."
Ergothioneine is an amino acid that is found mainly in mushrooms, as well as red and black beans. It is also found in animals that have eaten grasses containing ergothioneine. Ergothioneine is sometimes used as medicine.
@@gristlevonraben Molecular weight of Methylsulfonylmethane: 94.13 g/mol Taurine: 125.14 g/mol Cysteine (Taurine precursor): 121.16 g/mol Ergothioneine: 229.30 g/mol No, it does not
Wow, this is hectic, you made a complex scientific paper easy to understand in just over 12 minutes! Great work! ps I'll be back for the episode on pyruvate ;-)
Increasing respiratory rate artificially may have negative consequences, the vulcano plot clearly shows that there are severl metabolites that increase and decrease with exercise, all these metabolites change with exercise for a reason. So just supplementing ergothioneine may cause more harm than good. I would wait for a long-term study before considering this as a supplement.
I completely agree. This is one study that hasn't been peer reviewed, let alone replicated. One of my concerns is that if we increase mitochondrial respiration, we will also be increasing the production of free-radical species. We are only just scratching the surface here.
Visiting your channel for the first time. Good explanation. Normally I check whos talking first (phd in what, maybe publications etc). Id kept an eye on ergothioneine over the past months or so. Its getting more interesting but atm I will just eat my mushrooms on a daily basis (200g/d).
@@lonridgway2728 Glucose is broken down to pyruvate via glycolysis. The pyruvate is then metabolized is a chain of reactions that are termed the citric acid cycle (Krebs cycle)… I assumed you were asking a question based on the emoji, if it was a statement just ignore✨
I take NAC, am a vegetable consuming vegetarian, love and regularly eat oyster mushrooms. I exercise intensively and regularly. Have a low carb diet with a BMI od 22. Well muscled as well. I feel like crap most of the time. Ache all over.
Many supermarkets sell a 3 or 4 oz box of Oyster Mushrooms for 3 bucks to 4 bucks. Oyster Mushrooms are one of the highest grade source of ergothioneine and some strains of Pleurotus ostreatus (yellow oyster mushroom) can hit 11,000 mg / Kg or 11 mg / gram of wet uncooked mushroom. So a one ounce serving of common yellow oyster mushroom (28g) could be as much as 300 mg of ergothioneine for one buck for each days serving per person. Even if your oyster mushroom has the lower limit of only 1100 mg / Kg ergo, it is still a 30 mg serving per ounce of mushroom uncooked. Compare that to the claimed 5mg supplements sold on Amazon right now. I think the strain improvement of oyster mushrooms or the media they are grown on has just started and these little tasty guys may become a superfood dietary choice.
Fascinating in the context of Chronic Fatigue Syndrome and Long Covid, where mytochondrial dysfunction is suspected and yet exercise only makes the condition worse.
"uses more oxygen" is not alone a sign that it improves mito function. It could be, but it could also be that it stresses the mito, and it needs to work harder for the same outcomes. Too much guessing and assuming
@@mbmurphy777 Which likely also means more free-radical production, assuming that this non-peer reviewed study is successfully replicated (most initial positive studies fail on replication).
Anything that assists in enhancing the function and ability of the mitochondria is a potential tool to help in the treatment of cancer. Thanks for bringing this supplement to my attention!
The Oyster and Shiitake mushrooms are supposed to be very good sources of this aminoacid and some people claim they can improve workout performance and have antiaging properties. Does it make sense?
Ergothioneine was in my healing stack (arround 20 supps) 2 years ago. There was also reishi, chaga and all the antioksidantrs :D It cured my psoriasis. Tho as I said - 20 supps a same time - who knows what role Ergothioneine did there if any.
Methylene Blue increases mitochondria oxygen consumption around 30%, what happens when using both? Do you turn green and rip your clothes to shreds? How does oxygen concentration affect this process?
@@Mr_Penguins_Pet_Human If you don't mind, are your symptoms completely resolved? How much do you take, and how often? Do you have a recommended source? Thank you for your consideration!
Middle aged guy here. Well, I picked up _Life Extension L-Ergothioneine_ @ 5mg / day to see how effective it might be. There was one study from Blue California _(also makes this stuff)_ showing improved sleep. My sleep is notoriously bad, so if it improves, then maybe this product is perhaps also doing the other things this new study purports.
Seems promising. L-Ergothioneine seems to be available as caps with vague claims of beeing good for aging skin, is this the same stuff you think? We all could do our own n=1 study and see we notice anything in the gym :P
@@mballerI think ergo is a type of fungi and various types of mushrooms contain ergothienine. Though some contain more than others. I am not sure which type contains the most.
I process and track pretty accurate data for running and have had seen no additional improvement from NMN supplementation during my current base phase. I might try this one to look for a statistically significant increase in avg GAP times over the improvements I have seen in May.
@@MrJohnson57 It begins to break down chemically after 30-45 days. The bottle I purchased from Nutricost has no manufacturing date, but the expiration date on it says "02/2027". Which is about 3.8 years past 45 days to give you a good idea about how reliable these suppliers really are.
@@thepatternforms859 Recovery? Your mitochondria are going to recover by the next day. That's not what you are recovering from after a workout day in running (higher intensity). You have all of these waste products from burning glycogen in your fuel mix. Go to threshold and muscles are going to require at least another day to recover fully. That has nothing to do with mitochondria, though. You can go out next day to do a base run. Mitochondria still work fine as you stick around mainly in your aerobic system. The products are marketed as mitochondrial boosters -- and I saw no improvement over what I normally would have seen from training. Furthermore, I have discovered the chemical breaks down after about four weeks. The bottle I bought has an expiration date like four years from now.
Hmm... digging deeper on MPST: Dietary Supplements: While specific chemicals directly enhancing MPST production are less documented, supplements that support mitochondrial health, such as Coenzyme Q10 and alpha-lipoic acid, might have an indirect positive effect. Sulfur-Containing Compounds: Since MPST is involved in sulfur metabolism, dietary intake of sulfur-containing amino acids like cysteine and methionine might support its activity. (This is interesting because NAC is part of the GlyNAC duo that has been highlighted in another study for improving the hallmarks of aging.)
USC has discovered the protein humanin to play a significant role in the health of mt. Might be a good target for supplementation since its levels drop with age.
so our ancestors had it right?... work is necessary to live?... hummm. so sitting at a computer screen all day is not work in the sense that the body does not recognize it as work ? .... walking to school, walking to the store, walking up stairs not taking the elevator, .... ride a pedal bicycle not an electric bicycle... keep moving while you sit?.. answer : easy to do even if youre old disabled and cant drive, like i am. .... thanks❤
OK, so if ergothioneine increases, that suggests either (1) exercising mice eat more ergothioneine containing foods or (2) they biosynthesise more ergothioneine. However, there's no evidence animals can biosynthesise it themselves, and assuming food intake in the experiment was controlled... Where did it come from?
Hi, I am interested in learning more about HDL, specifically when it’s measured as “too high” (90). My doctor said she’s not worried because it’s the “good kind”.
I'm trying 10:1 extract of Cordyceps mushrooms instead of 5mg Ergothioneine, since it's way cheaper, and most supplements are just derived from that mushroom anyway (and listing 5mg Ergothioneine followed by the mushroom in large quantities).
When i saw your Astaxanthin clip I wanted to ask you to make one for Ergothioneine since it's becoming the next antioxidant trend in the market. I believe Quercetin till now is the most "proven" antioxidant when it comes to it's benefits. Now, is Ergothioneine really beneficial especially for skincare?
I’ve been getting daily ergothioneine in the form of beef kidney. It’s done wonders for my hormones, hair/skin/nails and overall happiness levels. Now this could also be due to the wide range of other cofactors, peptides and minerals present in the bovine kidney. Going on an animal based diet drastically reduced my need for most supplements, but when i do take them i love the food based ones such ans organs. They’re much easier to assimilate and breakdown for people with vulnerable digestive systems. Over time my body just totally rejects ultra processed supplements the same way it rejects ultra processed food
Safety first! "The Panel on Dietetic Products for the European Food Safety Authority reported safe daily limits of 2.82 mg/kg of body weight for infants, 3.39 mg/kg for small children, and 1.31 mg/kg for adults, including pregnant and breastfeeding women." source Wikipedia
Has anyone suggested a likely optimum dosage for humans? If these numbers are correct, it would seem that most adults would want to stay under 100mg. A lot of the supplements seem to have about 5mg.
According to the "volcano plot", it looks like pantothenic acid (aka vitamin B5) isn't far behind ergothioneine in exercise-vs-sedentary concentration.
Wow that MPST experiment was clever. Common dosage in supplements seems to 5 mg - I wondered if that would be enough, but a cup of Shitake mushrooms has nearly 25 mgs and would be much tastier
I watched another video you Made because I was taking lion. Main mushroom and what I got from, it was that it really didn't do much now that i've Tossed it Now after watching this, I went to Amazon looking for the supplement. I'm surprised to find lion's maine was one of them
Noticed cytochrome c oxidase and thought of a recent theory i had after considering a way to activate the mechanism naturally rather than through close proximity 600 nanometer red light therapy. While watching someone speak about how little known and studied the results are at the moment, i had recalled that there was a seemingly rare type of red fluorescent fluorite (due to elemental impurities and it's interaction with uv light); it was said to be found in two places, Mapami and another place i can't recall but feel free to ask and I'll check my saved research. Point is that I'm sure there are metal substrate flashlights and I'm assuming that any small electrical signal to the cell could prompt just enough of this light to elicit this response, maybe sent through the crystalline structure of some element. The ATP increase was 16 fold
As with all supplements - and everything else, for that matter - it all comes down to situation-specific dose. Too little and too much are both bad, and higher or lower levels of something can cause other mechanisms in the body to shift to counteract the change, over time. Evolution has tuned biology well. Increasing the speed of one part of an engine without doing the same to all the other meshing parts is not going to result in better performance. Odds are, like so many other single button changes, it’s not going to be what the public thinks it is. Instead, it’s science learning another part of the puzzle by pushing and pulling at another small piece to see how it fits.
Ergothioneine is icreased in mitochondria from exercise but the body doesn't make it. So more is transported to mitochondria do to exercise but also is increased by supplementation?
thank you I will make sure that my Magics have more Ergothioneine in the future🍄 ah yes this was recently in the news, what is your opinion on this ? "Fish oil supplements may increase the risk of someone developing a heart condition or stroke, but could reduce the risk for those who already have cardiovascular disease, according to study."😅
I know I'll get negative feedback on this. My Doc teaches all his patients to dowse (don't laugh) I've been dowsing for years which means I only take the supplements I get a "yes" to - works better and much more efficient - it means my daily vitamins are only being consumed when I know my body really needs them - economical and it works. It's really primitive to have a set list of stuff that you take religiously every day
The only thing that sort of scares me about supplements that improve cells...is not knowing if they'll be a nice performance enhancing drug for CANCER cells : /
Interesting.. Not only does it sound beneficial but it sounds like it can provide info regarding other aspects of my mitochondria that Ive been attempting to identify on my own without additional testing. Further research also suggests this is fantastic enough in a plethora of ways that I should probably be taking it regardless lol Taking a look at where it is naturally found further solidifies my thought that all the different branches of life that evolved prior to us contain something we need on a regular basis in order to maintain our mitochondria. Anywho. Ordered some 25mg capsules that'll be here Wednesday🤷♀️😂
It is interesting that erythrocytes having no mitochondria and cogito whether ergo they do accumulate ergothioneine.
5 месяцев назад
a 100 kg man would need to consume approximately 1218.98 grams (or about 1.22 kg) of dried Shiitake mushroom per day to achieve a dose of 33.4 mg/kg of ergothioneine.
If this amino does in fact enhance “physical performance” like the study indicates, would supplementing with it be best done as a pre workout or post workout ?
@@baldwad Among the 14 evaluated mushroom species, Lentinula edodes (LE), shiitake mushroom contains the highest ergothioneine content and hence was used for the in-vitro studies. pubmed.ncbi.nlm.nih.gov/38036238/ Shiitake mushrooms are a very common dietary ingredient in (normally cooked) Asian food, and adverse reactions (from normally cooked mushrooms) are so rare they're practically unheard of in Asia.
This piruvate generate buy ergo and MP happens before the phosphorylative oxidation so in the Krebs cycle whos dont generate to much ATP as the phosphorylative oxidation and there complex 1 to 4. At least in theory i who possess a mitochondrial disease in the complex 3 will not work. I dont no exactly my issue but they found fat in my muscle biopsy so i presume some thing related to fat metabolism and answer why i do have fat in the faeces iam still waitibg the complete result for analysis of cyrochrome c oxidase that transport electrons to the complexes.
It’s so sad, they don’t even know if loading this substance is damaging when there is no physiological need for it. Always looking for results in a bottle, something to sell and make money.
![Ergothioneine: New Supplement discovered to Improve Mitochondrial Function [Study 295]](/img/logo.svg){kind=logo}
