Being breastmilk was brought up in the discussion, pumped breast milk that was pumped at night. Should be fed to the baby at night, pumped breast, milk, pumped in daylight hours should be fed to the baby only in daylight hours. This is because the levels of melatonin are different in the breastmilk, depending on the time of the day. In another study, it was shown that melatonin levels of the mother in the third trimester affect the levels of melatonin in the baby for many years to come. If anyone is interested in these research papers, I will look it up and report back. I know it was a Student of Prof Randy Nelson who has done prolific research in this area that reported on the third trimester, melatonin levels in the mother affecting the baby
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Thank you Dr Perlmutter. You’ve taught us all so much by having these wonderful conversations. Thank you Dr Deanna too. I have no problem falling asleep but find it hard to stay asleep. Is this a melatonin issue or something else. It can be debilitating. I’m in my mid 60’s.
Deanna, Love you, big long time fan. Herbatonin is mktd as a sleep and circadian aid on AMZN. And that gets a lot of negative comments from those it does not help w sleep. Most ppl only think of MEL for sleep aid, and quite frankly, it doesn't work as a sleep aid for many. But, it will always act as an antioxidant. So, it might be better to rebrand MEL as an antioxidant.
Love this interview. I only wish there was more of a call to arms given the massive scale problem that is light pollution. Please join your local chapter of the international dark sky association and get involved with your town to implement dark sky friendly lighting! Hopefully one day blue light blocking glasses will no longer be needed…!
I took 5 grams of melatonin every night before bed for two years. It worked very well for over a year and then it stopped working to help me fall aslaeep. Melatonin is a hormone and if you take it on a regular basis your body STOPS MAKING IT. I had the most difficult time trying to wean myself off melatonin after the two years and trying to get my body to start making melatonin again.
Negative feedback to high Melatonin intake....has NOT BEEN OBSERVED NO negative feedback is observed by most researchers...MOST RESEARCHERS take HUGE DOSES of (hard to find) pure Melatonin. Your response to 5mg Melatonin doses...might have been ruined by poor quality Melatonin...THAT IS A BIG PROBLEM....many Melatonin Supplements have been found to have no Melatonin...and have been found to have Seratonin...AND...AND synthetic melatonin is probably total CRAP!!
Interestingly it actually doesn't stop the body's own production, rather high doses long term can reduce the sensitivity of melatonin receptor sites resulting in a dependence as you experienced. The solution is the low dose - 0.3mg which doesnt negatively impact receptor sites.
Thank you for bringing up this question. I've been asked several times whether we stop making melatonin if we are taking melatonin supplements. I cannot find any research to suggest this idea is true, but if you have studies, please share them. I have, however, found a number of studies which did not show this was the case. Here are some of the references I located: 1. Matsumoto M, et al. J Pineal Res. 1997 Jan;22(1):42-4. doi: 10.1111/j.1600-079x.1997.tb00301.x. PMID: 9062869. 2. Mallo C, et al. Acta Endocrinol (Copenh) 1988;119:474-480. 3. Lemoine P, et al. Ther Clin Risk Manag. 2011;7:301-11. doi: 10.2147/TCRM.S23036. Epub 2011 Jul 26. PMID: 21845053; PMCID: PMC3150476. 4. Lissoni P, et al. Recenti Prog Med. 1999 Feb;90(2):84-5. Italian. PMID: 10208098. 5. Dimah Sweis. Arch Dis Child Educ Pract Ed 2005; 90:ep74-ep77. doi: 10.1136/adc.2004.066498. 6. Reiter, R.J. et al.. Melatonin Research. 2, 3 (Aug. 2019), 105-119.
I'm 76 year's old and I have never had medical issues other than glasses and some dental. Never had a prescription, or aches, pains, acid reflux, bloating, headaches, constipation or any other issues. B/P between 112/67 & 114/69. Same weight as when I graduated High School (140 lbs/29" waist). So it is possible to remain in good shape.
There is melatonin in the body during the day in addition to the melatonin circulating. It is needed in csf it is made at night but there are many. Benefits of daytime dosing such as relieving sundowning in Alzheimer’s patients and for cancer treatment.
What is not addressed here is that 95% of the melatonin in mitochondria is produced locally from exposure to infrared light from sunlight during the day. You don't have to get direct sunlight. Reflected infrared off of the grass and trees in sufficient. That is how the mitochondria get the melatonin to fight oxidation during the day. The 5% you get from the pineal gland that circulates in the blood serum is what is concerned with quality of sleep. Check it out. The information is on RU-vid from real doctors and scientists.
There are numerous published (human) clinical trials using melatonin. It's been around for a long time, has a high safety profile, and would only seem to impart benefit for several facets (e.g., anti-inflammatory, antioxidant, mitochondrial, immune regulation).
I am watching this from New Zealand & very interested on the subject as I am working hard to stop a habit from my menopause years of waking during the night to have a pee! I am 73 years old & I am now successful in not getting up once I get to sleep, but getting to sleep is my issue! I would very much like to know the supplement you recommend but as it will be expensive to get it to New Zealand what are the important ingredients I should be looking for & their quantity??
Peeing is actually more related to estrogen. Have a look at a product in New Zealand called Femmenessence for post menopause that supports your body's own hormone production
My inquiry was not in relation to peeing I have cured my nightly waking for a pee - I was wanting more information on the Melatonin she was talking about?
Valerian helped me get drowsy. Also a nice warm or hot shower before bedtime helps me a lot, maybe a bath. Not drinking any liquids or eating within at least two or three hours of bed seems reasonable. I hope these ideas might help you.
If you don't want to take medication, a couple of pistachios have enough melatonin for a daily dosage (from a Nutritionfacts video). However receiving low to no light 2 hours before sleep and allowing the body to cool down a few degrees (e.g. taking a hot bath as mentioned above) helps the most (from Huberman Lab videos). Light at the end of the day should not have its source above your head, the brain reacts to it and wakes you up (also from a study mentioned by Andrew Huberman).
The video that mention melatonin rich foods has the title "How to Treat Jet Lag with Melatonin-Rich Food": Pistachio has 200mg per gram, so 2 of them are enough.
I stopped taking melatonin as it stopped working for me. It is still in process...still getting over it. I am now using some species-specific herbs & probiotics that enable us to make our own hormones and nutraceuticals in the gut. This is the future...humans making our own chemicals using food and pre/probiotics/and postbiotics in our own body. Sleep is getting easier. Some of the stuff I learned in Dr. Perlmutter's books. Lynne Potter Lord
For sleep you can try herbal supplements such as valerian, aromatherapy and triptophane which is precursor of melatonin. Also the problem for you might be not doing anything else to sleep better
Ok but if mice went well with melatonin at night, thats their active phase for them, so in humans it should be translate to taking melatonin in the day, to get the benefits observed!!!! You get this wrong, isn’t it???
Personally, I would start with the same dose - 0.3 mg per night - and go from there to see your personalized response. Some men do just fine with the lower dose.
I think 0.3 mg of melatonin from plant source is a common sense approach. I think the label for her Herbatonin says "first plantbase melatonin". But I know Nutrigold sells plantbase melatonin, made from Hypericum perforatum [flower] extract). It is at a whooping 5 mg though.
Nutrigold launched their product in 2019, Herbatonin was launched in 2007. You might like the research on Herbatonin from alfalfa and chlorella, which has been shown to be up to 646% more effective than synthetic melatonin. There is no research on hypericum perforatum and synthetic melatonin yet.
Herbatonin is the one with a published study, so that's why I prefer it! Here's the reference: Kukula-Koch W, Szwajgier D, Gaweł-Bęben K, Strzępek-Gomółka M, Głowniak K, Meissner HO. Is Phytomelatonin Complex Better Than Synthetic Melatonin? The Assessment of the Antiradical and Anti-Inflammatory Properties. Molecules. 2021 Oct 8;26(19):6087. doi: 10.3390/molecules26196087. PMID: 34641628; PMCID: PMC8512846.
@@foodandspirit I'm hearing from a headset and it didn't disturb me, but I noticed for example at 44:23 when you spoke louder, there's a distortion. Lowering the input volume may avoid this or using software that balances volume levels. Thank you for the great talk with Dr. Perlmutter. Just subscribed to you and learned a few things from your latest video: "vegetables that balance blood sugar"). Do you follow Nutrionfacts? One of Dr. Greger's videos mentions that pistachio has more melatonin than most of other nuts we usually eat.
@@foodandspirit the video is "How to Treat Jet Lag with Melatonin-Rich Food": they mention a paper that depicts pistachios varieties on a table and all of them have more than 200 micrograms per gram! So a couple of pistachios would be enough for the recommended 0.3 milligrams.
