Nattokinase Antithrombotic Mechanism of Action

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Nattokinase is a thrombolytic, spike protein degradative, and anti-aging enzyme produced by Bacillus subtilis. Nattokinase is produced by fermenting soybeans with Bacillus subtilis. Let's review its actions.
DrBeen: Medical Education Online
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FLCCC | Front Line COVID-19 Critical Care Alliance
covid19criticalcare.com/
URL list from Monday, Dec. 19 2022
File:Natto mixed by Kinchan1.jpg - Wikimedia Commons
commons.wikimedia.org/wiki/Fi...
Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease - PMC
www.ncbi.nlm.nih.gov/pmc/arti...)
Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2 - PMC
www.ncbi.nlm.nih.gov/pmc/arti...
A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles | Scientific Reports
www.nature.com/articles/srep1...
Mechanism of Action. Nattokinase dissolves blood clots by directly... | Download Scientific Diagram
www.researchgate.net/figure/F...
Coagulation and fibrinolytic cascades. Ca, calcium; FDPs, fibrin... | Download Scientific Diagram
www.researchgate.net/figure/C...
Coagulation and anticoagulation in idiopathic pulmonary fibrosis | European Respiratory Society
err.ersjournals.com/content/2...
Coagulation Clotting Mechanisms - Circulatory System - MCAT Content
jackwestin.com/resources/mcat...
Physiology, Coagulation Pathways - StatPearls - NCBI Bookshelf
www.ncbi.nlm.nih.gov/books/NB....
Intrinsic Pathway of Coagulation and Thrombosis | Arteriosclerosis, Thrombosis, and Vascular Biology
www.ahajournals.org/doi/full/...
Plasmin - Wikipedia
en.wikipedia.org/wiki/Plasmin
Urokinase - Wikipedia
en.wikipedia.org/wiki/Urokinase
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

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8 янв 2023

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Комментарии : 117

@copisetic1104 Год назад

I had a DVT in my left leg from my ankle to my waist. I was in the hospital for four days after enzyme treatment. The leg was in great pain. I started on 16,000 F/U a day and within two days the pain virtually disappeared and the leg was almost back to normal in a week. My dr. And myself are almost positive it was caused by Covid 5.

@vapeking466 9 месяцев назад

When you say enzyme treatment are you speaking of nattokinase or something else? I have had a huge blood clot also in my left leg but it was over 10yrs ago. They gave me lovenox shots daily and admitted me for a week at the hospital. After that I took low dose aspirin to help prevent reoccurring clots or heart attacks. However I stopped low dose aspirin couple weeks ago and now am taking 2000fu of nattokinase twice a day on an empty stomach. However I can't say one way or the other if it's done anything. I suppose I will just keep taking it for now unless I develop a clot or have a heart attack. I'm age 50 my father already had his first heart attack by age 40. I'm just trying to be as healthy as I can be for as long as possible.

@sabbathd1 7 месяцев назад

@@vapeking466get a D diner you will know if it’s working…get one now than again in 4 to 6 months

@parody_bear_mike 3 месяца назад

@@vapeking466 pycnogenol

@eugeniebreida1583 Месяц назад

@@vapeking466Yours is a low dose. I take 3 - 4,000 fu’s 3 times a day = 36,000 fu’s. Also am taking 2 - 120,000 units Serrapeptase 3’s/day, both taking together on empty stomach w/water. Am in my first full week of therapy, and am Very Excited! (circulatory issues/edema/arthritis )

@stacydewet 19 дней назад

D-Dimer blood test can confirm

@oldschool8292 Год назад

You have no idea how much I wish you could be my doc Dr Been. I have so many medical issues complicated by extreme sensitivities that I really need a well educated Doctor that enjoys a challenge 🤣 Thank you so much! You are amazing.

@caroliner2029 Год назад

How very interesting, thank you Dr Been for this detailed and comprehensive presentation. I've started taking nattokinase and also started making natto in my kitchen. It'll make a delicious dinner tomorrow with chicken and spicy kimchi. The clotting pathways in your drawings are my old friends. When I started in coronary care, we still gave streptokinase to a few patients. This treatment changed to urokinase, which was better tolerated, and then I remember infusing TPA to patients who had had angioplasty and were recovering. Not all patients were given stents when I started. The action of NK on our biology is wonderful, especially as it isn't denatured by our gastric acid or gut bacterial. It has no apparent downsides. Looking at our clotting pathways in your drawings, I'm again awestruck at how humans are masterpieces of God's creative genius 🥰🇦🇺

@veredictum4503 Год назад

Fermenting own natto would be brilliant, because the only ones I find are in the freezer section of Japanese grocery stores. Expensive!!! But where do you get the bacteria culture from? And is it safe i.e. will "other" bugs be growing too (zero idea about fermentation).

@bonniewilliams9171 4 месяца назад

Amen!

@horsevideosbymary2723 10 месяцев назад

This is a fabulous lecture for anyone with a modicum of physiology background. As allopathic medicine fades into the background (hopefully) the more we take on the responsibility to educate ourselves and those around us the more we will achieve wellness. Thank you Dr. Been!

@chadclay01 Год назад

I was doing 4,000IU for 3 weeks. Was noticing somewhat of an improvement but then got sick mid December and that knocked me back. From different sources I read people have had more success at 8,000IU. I have started at that amount 1 week ago. I've had chronic brain fog for 3 years which I believe was brought on by Covid as I tested for antibodies and was positive. I am also take 120,000IU serrapeptase. From a study the natto should be enteric coated and should be taken on an empty stomach.

@scotttucker9613 Год назад

how did your 8000IU course go, Chad?

@engc4953 10 месяцев назад

So you are taking Nattokinase along with serrapeptase?

@supremeteam1831 6 месяцев назад

It shouldn’t matter as long as it’s taken on an empty stomach

@Mary-Mercedes Год назад

*Dr. Been you are a gift to the universe.* Brilliant. Thank you yet again for another CUTTING EDGE report. You sir, are ALWAYS ahead of the pack and courageously provide your wealth of knowledge and research free to all who will listen. I've been taking Nattokinase for years now and consider it an essential supplement. God Bless you Sir.

@meanqkie2240 Год назад

Gifted speaker and teacher. Very smooth and soothing voice with zero annoying habits! Thank you for presenting this material in such a sensible progression, and explaining so even the lay person can grasp the main concepts. Well done! You remind me of my Physics professor but you are even easier to understand! Thank you. God bless.

@metal.gendalf Год назад

OMG OMG My mind is blown I was getting bacillius subtilis as a regular probiotic and accidentally felt myself getting better. Well, now I know why! Thank you for your great work ❤🙏

@sorenkierkegaard3 Год назад

Dr Been, you say that natto has been used for thousands of years but one difference is that therapeutic forms of NK are in delayed release pills surviving the stomach acid. This is surely a new phenomenon and we need to be cautious in inferring complete safety from it's history as a food. I am using NK in patients and am glad to have such a novel and useful agent however. Thank you again. Your graphics and explanations give me confidence in using old/new agents like methylene blue, LDN, NK etc.

@adonnaprice9676 Год назад

For people taking a blood thinner and only interested in natto killing the spike, can you address that? Thanks

@karenf9137 Год назад

Doesn’t it depend on stomach content, or lack there of?

@sonnygmony 6 месяцев назад

You are doing God's work, my friend. No matter how you understand Him.

@superbeingintraining1970 Год назад

Thank you Dr Been! This was super helpful!!

@AP-nf5mi Год назад

Dr. Been, how I wish I had been able to have your excellent tutorials when I was in training.🏆

@MichelleL20942 Год назад

THANK YOU ‼️ AMAZING‼️Looking forward to the next chapter‼️

@SupremeODMG Год назад

Dr Been is amazing.

@gemmasawh3628 Год назад

Thank you Dr Been for making this so simple to understand.You are a great teacher. I take nattokinase but never had all the information you presented. Bless you.🌟🌟🌟

@terryruiz8854 Год назад

I have to say that was very interesting and well done. Thank for you time in presenting this

@scottp6761 Год назад

Dr. Do you believe that Nattokinase reverses the spike protein from the Moderna vaccine? I have been taking capsules daily now for 2 weeks. It's helping my blood pressure and I feel better. Also the ringing in my ears is less since taking. Both had been worse since Vaccine in 2021 of August when I took that poison. I did not get boosters. Anyway love to hear your opinion on Natto on reversing and dissolving the spike protein in our body.

@4406bbldb Год назад

Good question!

@petermalmgren1207 Год назад

I have seen some studies that say it does

@scottp6761 Год назад

@@petermalmgren1207 I keep taking it everyday. I will just to protect my heart and it keeps my BP lower. Protects your brain too from stroke.

@gnosisdespirit Год назад

I'd look into Serrapeptase as well as look into Traditional Chinese Medicine, Ayurveda and Western herbalism for REAL ANSWERS to your health problems.

@theclotshotdidit3115 10 месяцев назад

I think there might be some research on Ivermectin dissolving the spike too, get plenty of vitamin D too, should help you avoid the virus giving you more spike protein

@veredictum4503 Год назад

Dr Syed, besides your obvious knowledge and research, your other great value is the ability to teach, using simple language and diagrams, for ordinary folks. Wonderful stuff! And I sure will be taking all this advice to heart (pun!)

@mnrois 9 месяцев назад

Thank you Dr Been for sharing your wealth of knowledge and erudite presentation. Your teaching have blessed me and so many people. May God bless you to continue your work.

@michaelmartinelli2163 Год назад

Dr. I experimented with NK recently. I am 4 months post covid. I took it for a week and happened to have lab work at that time. I tested elevated for ESR (26) and CRP (18), so not a huge elevation. But is it possible the elevation was due to the NK working and causing an increase of fibrin byproducts/inflammatory cells from the microclots released into the blood. I know fibrinogen can give falsely elevated ESR. I stopped the NK for now until I get labs again in few weeks to see if tests are normal. I am a pharmacist and I found this very interesting.

@dickg3523 Год назад

Excellent presentation; thank you so much

@debstayblessed9549 Год назад

Awesome presentation

@sandraedlinger4663 Год назад

Wonderful video, thank you! 🙂

@rhydyard 11 месяцев назад

Superb, erudite presentation.. thank you!

@westfield90 10 месяцев назад

Only concern is if it thins the blood then don’t you have to worry about a stroke or disrupting existing plaque which can then move to another location such as the lungs or brain

@Broski-vo6he 8 месяцев назад

I'm also curious about this..

@heather2081 Год назад

This was VERY informative and helpful! I am about to come off of Lovenox after a major clotting event in my pregnancy and this gives me so much peace. I’ve ordered Nattokinase, Serrapanese, and Lumbrokinase to take. Just trying to figure out what type of protocol to keep me healthy and clot free going forward! This was so helpful in understanding the clotting cascade as well as the breakdown of clots. I know blood thinners don’t bread down clots so I’m excited to start the enzymes. I want to send this video to my hematologist because he’s skeptical about natural remedies haha!

@karenf9137 Год назад

H, you may want to research the importance of Vitamin D during pregnancy as well. Bruce Hollis, Ph.D. has published quite a bit, but there’s plenty out there to read. Peace.

@stevemc2626 Год назад

Awesome talk (again). I would love to know the direct impact of Nattokinase on Lp(a) and it’s clotting abilities. As a sufferer of very high Lp(a) Nattokinase sounds like at least a partial answer to my problem.

@felixcat9455 Год назад

Interested as well

@acidtechno Год назад

Your Are A Light In The Dark ❤

@chaitanyadandavate8633 Год назад

Excellent Dr Been . I did eat Natto once

@SupremeODMG Год назад

Natto has helped my leg cramps and swelling. Idk if I had a clots from this or not but I have DVT in kegs. I am taking g this and wearing compression socks.

@jazzsnare Год назад

As a red meat advocate, now I take berberine and natto (thanks to Dr. Been) to prevent inflammation.

@baldwad Месяц назад

How bizarre. An advocate for inflammatory food taking plants to prevent inflammation. That's cognitive dissonance right there!

@christine41861 Год назад

Excellent topic!!! In chronic Lyme would this taken for LC effect my fibrins w the Lyme infections and I worry about a Herx. I’ve wanted to try this during my 18 months now LC. Brain burning I’m certain is brain inflammation of some kind…. 🧐. Thanx Dr B! Great series

@johnjames5405 Год назад

I didn't know you had two channels.

@rhondaw6503 Год назад

Fascinating even for a non techie person! At what dose do you get this fabulous action from NK?

@garsonprice3441 9 месяцев назад

Another clinical test says 10,000 FU per day is a minimum dose. At this dose your spike proteins will dissolve. Otherwise these bad proteins last at least a year in the body. Time will tell if they ever dissolve on their own as Big Pharma states. Dr. John Campbell has a wonderful RU-vid channel and covers (among many health issues) the anomalies of Covid in detail.

@DT-lf2up Год назад

Subscribed

@atlet1 Год назад

What is the risk of NK, if taken on blood thinners? Can it be used as alternative to them.

@johnzabroski5396 2 месяца назад

You should not combine them. Could cause a stroke or similar very bad outcome.

@billytheweasel Год назад

thanks dr sayed! i'm wondering if there's a way to know if we have a problem in the endothelial layer or blood vessel wall that needs fibrogen repair? so, is there a condition, like vasculitis?, where natto should be avoided?

@quantumeseboy Год назад

Did you do a video on Lumbrokinase?

@stegibabajamashim4390 11 месяцев назад

Where this video lets the viewer down is that there is no explanation as to what happens to a clot (say a DVT) after nattokinase has broken the clot down. Does the clot break away and form an embolism in a distant part of the body? (Or is the broken down clot eaten up by other bodily processes)?

@debbiecote3993 8 месяцев назад

You mention follow up videos on nattokinease but I can't those. Are those coming or did I miss them on your channel?

@Ashley-xq2bt 10 месяцев назад

Check out dr William Wong on systemic enzymes. Also excellent presentation with great q&a at end

@MaurilioPatinoPerez Год назад

Dr Been, could we use Cerebrolysin for long covid brain fog?

@ostbob4108 3 месяца назад

So what blood test should one get if on Natto and what are satisfactory results to look for. I'm taking 6000 FU daily but the only test I look for is the Fibrinogen one which is 285. No sure if that enough to stop DVT or not. should I get a Dimer test and if so what is a good result?

@Michael.Moawad 9 месяцев назад

What if other legumes, such as lentils, for example, were fermented with the same bacteria Bacillus subtilis and converted to natto, would I get the same benefits from the nattokinase enzyme and vitamin K2?

@larerevokit1 6 месяцев назад

NK will grow on any grain

@sharonillenye8036 Месяц назад

does NK have any interaction with LPa on apoB LDL which has plasminogen like Kringle repeats ? I have tried to take 4000FU NK for a few days, but having pain like angina. I also have LPa level of 486nmol/L with high LDL 255. I am going to try taking again just a couple times a week instead of daily. I eat soybeans so I don't think its an allergic rx. I also tried eating natto and no allergy just couldn't get used to the taste.

@accordionchick 8 месяцев назад

@DoctorBeen, I noticed that many people here use Natto in big amounts. One person said 16,000 FU a day. Is that safe? I am trying to break up \/dissolve any blot clots that are in my brain due to a previous stroke and also in the neck veins. Can I do like that person and take 16,000 a day. I very much want to lower my blood pressure and I am being sooooo good but so far not much change. What do you suggest????

@libertysong1 5 месяцев назад

The other comment on here is right. That being said, I have been taking 2000fu and my blood pressure lowered by over 30pts. I would be very cautious about taking a larger amount like you are asking about, 16000fu.

@eugeniebreida1583 Месяц назад

The natto enzyme will only clean up broken proteins, it does not ‘thin’ the blood beyond ‘healthy state’/it will not attack healthy tissue.

@johnkuncho7239 2 месяца назад

I had extensive internal surgery (Whipple procedure) more than 5 years ago. Is nattokinase safe for me to take?

@lancelaw5966 5 месяцев назад

This is the Real shit,not the vague crap that u usually get

@abbastaylor4716 7 месяцев назад

I have a stent in one of my coronary arteries. Is nattokinase safe and useful for me?

@yahyahdayahsharel9893 Год назад

How much should one eat if they're using the actual beans and not a supplement?

@scheduledrest4316 Год назад

I wonder how sensitive this enzyme is to heat, for example when cooking the Natto.

@caroliner2029 Год назад

Good question. I watched some videos on making natto to find a way that I could do it in my kitchen, and everyone cooks the soy beans or chickpeas first, before adding the culture. The culture isn't cooked. They ferment it with careful warming. I'm doing my first experiment today with my yoghurt maker. I'm hoping that it works, because it seems like a beneficial food (even though I eat low carb). I've got some spicy garlic kimchi to go with it, which will be delicious with chicken.🇦🇺

@halslentz-whalen9263 8 месяцев назад

Does Nattokinase show sufficient promise for CVD patients to drop Baby Aspirin and avoid the side effects?

@donnazukadley7300 5 месяцев назад

Gingko Biloba is nature's blood thinner

@eugeniebreida1583 Месяц назад

Aspirin addresses platelets, nattokinase addresses fibrin. Great duo to use : )

@simonamoste3668 7 месяцев назад

How dangerous is natokinase for an elderly woman 89 years old weak, strokes in the past, aortic stenosis, I am afraid to put her on eliquis, also on natokinase after a pharmacist told me an elder woman died of it

@donnazukadley7300 5 месяцев назад

SO many of my patients have had hematuria when on Eliquis

@LearningLife-sh1fh Год назад

Hello, do you think a person with CFS and IBS can take it?

@8mora888 Год назад

Yes, start slowly. Take a spoonful a day and work up to 1/2cup per day.

@rigaleb Год назад

There are so many brands of nattokinase... it's absolutely impossible to navigate. Has anyone got any benefit from certain brands?

@heather2081 Год назад

I ordered Dr.’s Best from Amazon’s and am starting soon, I’ll be taking it along with Serrapanese and Lumbrokinase. I could not afford the super expensive brands so I got Dr. Mercola and SerraRX, and am hoping it will help (I had extensive clotting last year in my pregnancy and am about to stop blood thinners) I can try to remember to update as time goes on!

@GeorgeKnew Год назад

Nattokinase NSK-SD is the form that has been studied and patented... I would recommend you stick to that form.

@literatious308 Год назад

@@heather2081Did you mean Serrapeptase? What has been your experience?

@heather2081 Год назад

@@literatious308 Yeah lol that’s what I meant! I actually have been doing great! I definitely feel better taking the supplements… and I had a carpal boss that was growing pretty large on my wrist, it had been there for over a year, and it’s actually almost completely gone since I started taking these supplements. I’m guessing it’s the serrapeptase mostly. I have had 2 normal d-dimer tests as well so that’s very reassuring!

@literatious308 Год назад

@@heather2081Thanks for replying! I'm glad to hear your issues are getting better. I read/heard somewhere that both Nattokinase & Serrapeptase supplements need to bypass stomach acids for maximal effectiveness, I think that's equivalent to enterically coated, though I seem to recall another terminology but my aged brain refuses to make that connection tonight. I bring this up because the marketplace has been flooded by many competing products & it's difficult to winnow the wheat from the chaff(effective vs opportunism). I haven't really seen much research on comparison between formulations. Perhaps you could post both Brands & dosage that have helped you. Thank you again.

@ronb9901 Год назад

How does Factor 5 Leiden fit into this conversation??

@stegibabajamashim4390 Год назад

I asked this question over a month ago and find zero response.

@ronb9901 Год назад

@@stegibabajamashim4390 I’ll keep searching for info on that.

@robertedwards9254 8 месяцев назад

Hematologist just told me I have a blood mutation and he mentioned Leiden Protein. I have two Pfizer doses.

@1961Lara Год назад

Ugh…. My niece eats that…. I can’t get near it…..gag…

@scottp6761 Год назад

It's not good tasting. Just take the capsules and find them on Amazon

@kathleenking47 7 месяцев назад

It's bad, but not as bad as chitterlings, (hog intestines) and NATTO is HEALTHY. People in Okinawa live in their 90s and 100s

@Thesortvokter Год назад

Wonderful ❤

@alexandrecouture2462 Год назад

I tried it for about 2 months last year and I saw no difference on my long covid. I may revisit it again. BTW, why isn't this on Dr Been main channel? It would have much much views and visibility and not be associated with flccc.

@scottp6761 Год назад

Did you take capsules? Try that. Find them on Amazon.

@user-xc9sv5hk2d Год назад

I have tried almost everything, thiamine is good but what helped me depending on your symptoms is Life Extension Mitochondrial Energy Optimizer with PQQ, it has Benfotiamine and thiamine with R-ALA but my doctor said higher dose of R-ALA up to 600-1000mg was better so I increased my dosage, I have also done low dose nicotine patches for brain fog which has helped some…but I went from laying on couch all day exhausted to almost back to normal with exception of my slight tinnitus and one area of inflammation which is why I am her watching video, maybe dosage for NK needed to be higher I have read where people took higher doses Good luck!!

@user-xc9sv5hk2d Год назад

Oh I forgot lol not sure what time of day you took NK can make difference: When you take the enzymes with food, they help digest food, When you take on a EMPTY STOMACH, 2 HOURS BETWEEN MEALS, they quickly enter the bloodstream and clean BLOOD, TISSUES and ORGANS. They clean out proteins that don't belong in your BLOOD, TISSUE and ORGANS.