Reverse Aging: Dr David Sinclair on NMN & Anti Ageing supplements (including their side effects) 

Interested in longevity and optimising health? We dive deep in our new episode with the man who ages backwards ➡*Bryan Johnson* ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-nWAEXbJVAto.htmlsi=Qm8I-5ucgZQ8b7dq&t=1 Bryan shares his biological age, training regimen, and strategies for enhancing V02 Max. Watch now on World of DaaS 🧠🥬💪

in a word.... FASTING! I've been intermittent & long-term fasting for 40 years, the last 15 very seriously. I'm 67 and people never guess my age. Recently, someone guessed 52! I smiled and said...older. I didn't want to shock him. That said, a diet w/o sugar and processed foods is mandatory! Also, gut healthy foods are needed for healing & repair. And an active lifestyle. Once your body cleans out the years of toxins, a bad diet will actually get you very ill feeling.

I started when i was 27. Diet change from anything and everything to 80% vegetables, fruits, and legumes manly. Started fasting around the same time. Day fasts, 2,3,4,5 day fasts, just water. Upto 8 day fasts. Drinking upto 1 litre of water a day. This was incorporated over 5 years. Over last 5 years been working into my lifestyle intermittent fasting. First taking out breakfast, which took about 1 or 2 years. Then lunch. Now at the stage of Monday to Friday i eat in 2 hour window in evening. Breaking fast with homemade yogurt, with L.reuteri (see Super Gut book by William Davis). Been taking Ceremonial Grade Matcha for past 1-2 years most days. Cold baths almost every day in the morning. Now, this year (been on the to incorporate list) starting with NMN, resveratrol, quercetin, vitamin k2, d3, C, Omega 3s, B12, and some others. I've never taken any supplements before this year. Always thought I'd do the free stuff first, like fasting, exercise, cold baths, etc, and then add on the other stuff. Im 37 and last month had my age guessed by 3 people of different ages from 23 years old to 45+ and all said they were sure i was in my late 20s and were quite shocked when i told them my age. That was with my beard longish. When i shave it off, i look 5 years younger still. Ive never, ever consulted a doctor regarding what i do. The reason i started it all was because i was diagnosed with IBS and they put me on some powder stuff which didnt work and went back and they wanted to put me on something else and i said "if you think im going to believe you after you said that powder would work and it didnt, im not going to take those now am i". Left and never looked back, took my health into my own hands, read loads, researched and applied it, cured myself in a month or 2. Not easy to change years and years of habits ingrained into each of us, but if you chip away little by little, you will achieve loads in 5-10 years. My advice: dont try and do it all at once. You will not be able to do it. Accept you dont have enough willpower to take it all on at once. Pick a couple of things you want to address/change and focus on that. If you do this, you won't even notice the change, and 10 years goes by, and like i do, i think "my lifestyle is nothing what it was 10 years ago." Replacing habits takes time, dedication, desire and effort. It is now effortless for me to do 48 hours without anything but a few glasses of water. I can work all day in my manual labour job without eating anything to 6pm sometimes no problem. Now if i eat, let's say a bowl of sugar cereal in the morning, I feel utterly terrible. Its important i found to not be 100% strict. I found that letting myself have what i would have had before once of twice a week is really good because you have that contrast and i re-realise why im making effort to change that.Peace to all. Its never too late to change. 😊

Look up Sinclair's role in the FDA banning NMN from being sold without a prescription.

I've only been doing fasting for about a year but I have been skipping breakfast for over 30 years not realizing it was called fasting. I find it interesting that so many people back then would scold me for not eating breakfast. When I go two or 3 days fasting I still get a lot of feedback from people. I think the first thing they ask is "aren't you always hungry". With the concept of fasting be coming more😁😁 accepted, those people who questioned me before now look at me as if I'm a trendsetter. With all the information that's out in the world on the benefits of fasting, I now just smile and let them go on thinking and I'm smarter than the rest of the people or ahead of my time. 😊

Living in remote part of Africa and I benefit from your podcast on healthy lifespan. Thanks for all your efforts

Some constructive criticism for the interviewer....try not to interrupt. Keep up the good work

8:30 10:40 13:50 Sinclair's diet talking about longevity and and fasting went from total fringe(border or outer edges of an area or a group) in science to now mainstream

Dr Sinclair often mentions he has some sleeping problems. Taking NMN I've noticed that his dose was definitely too high for me and I too experienced some sleeping problems, literally it shortened my sleep from 8 to 6 hours. I reduced the dose and my sleep improved right away. So my conclusion is - although studies show that NMN is good for us (or other supplements), we should adjust dosing to our own needs, because after all we are different (body type, body sensitivity, nutrients absorption re stomach acid etc).

I was studying health since the days of Adele Davis and just kept on learning. Bad accident put me on my back. Hispital and rehab kept me from my project found Dr David Sinclair researched NMN and got it; I try not to miss anything he reports or says. What NMN does for one is amazing

I've been taking NMN for a while. I am 53 and yesterday someone said I don't look a day over 52... that's proof enough!

The only side effect so far for me (just started taking it) is I must take it first thing in the morning or I don’t sleep

I love this Dr Sinclair . He is so intelligent and nice

I've been taking NMN and NR plus AKG and TMG powder.

David does looks younger than several years ago. Something is working for him.

Dr. David Sinclair is a great speaker but not sincere he does "own" different companies that sell his supplement recommendations. Do your homework in research. I have seen him here for two decades and tried his expensive supplements. Longevity is gained by eating good food and exercising! It has propelled me into my later years watching friends and family go by the wayside. He actually looks a decade or more older he himself is growing old! We all grow old it is a fact of life. Stay healthy!

It would be intersting to learn about the long-term NMN supplement effect with regards to exacerbate inflammatory arthritis

nad plus is fantastic. i feel me vrey young again

Where is the best place to buy NMN

Transformers anti aging starts right now! We fight 60! And I would love to be Dr. Sinclair’s assistant and we can get all the help we need.

Is sirolimus from India safe to take?

What supplement or med did you slip and mention at 4:50? Before correcting to resveratrol?

Doesnt berberine mimic Metaformin?

I just saw a news article about the FTA banning NMM?

I love Mrs. St. Claires

My heart volbe is change and I have a sugar can I use it sir please answer me

CDXC is selling NR. Last year Aug analyst's prediction of the stock price was ~USD5 and this month one prediction is the same. Actual is ~1.5. Harvard and other scientists are selling and betting pn this, including Cure's Alzheimer's disease fund.

Dr. David A Sinclair, I'm a 73 yrs old male; from Miami Florida'; that looks such as yourself ; 50 yrs old. I have a beard, when I remove it , I look 40+, I just might be your missing link to all this big question on aging!!!!!!! I just carry this gift! and I'm Diabetic type II since 2012. No lie! Would I be up for study?? I don't do anything for it!!!!!! Might be ideal for space travel!

I tried to find this pre internet . My father had Parkinson’s. I was there , just couldn’t find what I needed !

How long time it hold in world human body

NMN has been LIFE CHANGING for me. I actually started out with NR which is a precursor to NMN. It started when my geriatric dog, started getting very sick. He had been sick for a long time and its just been getting worse. He didnt want to be touched and only wanted to lay in bed and sleep all of the time. Well, my sister had a cat with kidney failure that was given 6 months to live. She gave the cat nmn and it began to recover and started eating again. After a while, the cat was normal again. It did end up dying but because of the nmn, it lived an additional 22 months! So, back to my 14 year old, elderly dog. Id spent thousands of dollars at the vet amd he was not getting any better. I was sure he was going to die so I started him on NMN. He was in really bad shape and it took him 3 months before I saw any improvement. But one day, I notced that he started felling better and as time went on, he got better and better and better. He is so healthy no that he no longer lays in bed all day. Not only that but he plays with toys again. Id not seen him play in years! And even better, he does it every day! 2 years later, he is still alive. Hes a happy little dog now that barks at strangers and walks around the house all day doing dog stuff instead of only sleeping all of the time. After I saw how good he was doing, I thought, " Damn, I want that for me too!" About myself. Im 44 but suffer from grevious mental illnesses. I was almost alway miserable all most all of the time and contemplating suicide. So after seeing what it did to my dog, I started taking it. It only took me 2 weeks to respond to it but when I did, wow! Oneday, I noticed I was feeling a little better, and the next day I was even better and the next day the same. This went on for a month and by the end of a month, I was on top of the world, I had not felt this good in damn YEARS! My mental health problems are not gone but they are very light now, so far as to say, Im not suffering at all anymore. But it should be noted that after discovering how nmn workd for me, I embarked on a journey to find other suppliments that might help, and I did! Im not even close to the same person anymore. I love life now. Due to my metal illness, my memory was crap and I was constantly forgetting stuff. Well tha5s got now but now its even better. I remember everything! Ive never had a memory this good. My wife is on the stuff also, as well as my 72 year old elderly mother and we are all expirencing similar results bit it definitely helped me the most because I was so bad off.

Can NAC rand Spemaline help raise NAD Levls like NMN?

I'm disappointed with David's company getting nmn banned. This is a direct copy of what he did with the grape skin supplement years ago. Still I love the guy. Looks like a good bet to crack this ageing problem once and for all. Fingers crossed.

Little or no mention is made of the use of micronized metformin in transdermal cream, which I myself have used for many years. An important detail: the dose should be 10% of the oral dose.

How can I get in Nepal bro nmn subliment

NMN TMG changed my health / life

I will take mnm

Someone do an interview of Dr Sinclair's age reversal molecule that Harvard medical just discovered.

I'm looking for it MNM but NAD comes up. Is it the same supplement? Where do I find MNM?

How can you get metformin?

20 years later no closer to any cure for ageing. In 2003, his lab was small and struggling for funding.[3] In 2004, Sinclair met with the philanthropist Paul F. Glenn who donated $5 million to Harvard to establish the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard.

Taurine, Glycine, and NAC. I try to walk after every meal.

Please do a show on how important, or not, eating organic foods is. I don't see any shows about this, but feel it has to be super important to NOT put" bug spray" on our foods! 14:12

You are your own best health advocate. Eat a healthy whole food plant based diet, reduce stress, get adequate sleep and exercise regularly. Every adult and child should own a bicycle and ride it regularly. You will be healthier, happier and have lower transportation and health care expenses. Make a bicycle your first choice for short distance travel. Exercise and stay active.

Hello, Where do we get the NMN? Everyone on the internet says there's is more pure.

Some are commenting negatively about his mostly Vegetarian diet. Personally I am NOT a vegetarian, I love my meat, and realize that meat protein and fat are critically important to people like me who follow a low carb/keto diet. But I also pay attention to all blue zoners. The Loma Linda seventh day Adventist are vegetarians and they are blue zoners. They do not eat meat. Thoughts?

There is a main cell in the body, it has a thought, this is the soul, all information is stored in it, and it is immortal. The decision is made by the thought of the main cell

The Seventh-day Adventist Church has been recommending this similar advice e.g. fasting (along with prayer), hot & cold therapy, plant based diet, rest, water, rest etc for more than a hundred years. Look up Loma Linda Blue Zone too.

“One of my companies is doing clinical trials”….”but I’m not selling the stuff”. - Sneaky Sinclair 2023

Where can I buy metformin and rest?

John Brzenk is "old" for a competing arm wrestler, he says he takes NAD and he still wins, why take NMN instead of NAD? Add in jiaogulan and carnosine.

Before there was NMN there was NR.. We can always go back to taking NR .

Is NMN worth the cost? Some people do not benefit from NMN or resveratrol. I prefer Niacin - a cheap precursor.

How does David get Metformin as it is a prescribed drug?

7:29 ghosttttt in david's background

Apparently new research is showing NR to be more effective than NMN

NMN dramatically raised triglycerides in one small study. What's up with that?

What hair-dye and colour does Mr. Sinclair use?

I hope Dr Sinclair has read the research papers (since the talk with his doctor) that high cholesterol DOES NOT CAUSE HEART DISEASE. Only an oxidative form of LDL can cause heart disease OR very high triglycerides along very high cholesterol and glucose are reasons to take statins.

Interestingly enough, There have been several studies showing that NMN does not have any effect on the body, positive or negative, furthermore, it seems to be absorded and broken down too quickly and has never shown to increase NAD in muscles. I urge people to actually do their own research or listen to opponents of Sinclair to get the full picture. I understand, however, that getting information from videos like this is far easier. Note: there are other anti aging drugs that have shown great promise.

I thought NR was better than NMN. What a pity that Dr Sinclair was about to speak to this when the interviewer interrupted him

Critical Findings From 12 Key NMN “Anti-Aging” Studies Dr Brad Stanfield

Unfortunately nmn was banned by the FDA since it's not been researched as a possible drug. What's the best alternative?

NMN is not available in the United States anymore so I don’t know what he’s taking now.

What about NR instead of NMN?

I stopped taking Metformin, because it causes muscle waste plus bad stomach issues. I was taking BERBERINE for a few months I STOPPED FOR A WHILE 8:30 . I do take NMN with extra virgin Olive oil, and TMG, also NR, CalAKG from ProHealth Longevity here in California. USA. IM a strong senior.

We don’t think with our brains, each cell of us is autonomous, just as in a factory the director thinks about the plant, and the cleaning lady thinks about the mop. When a person's head is changed, you will be convinced that it is not the body that has been changed - the head, the main cell is in the solar plexus area.

I keep seeing videos that the FDA banned NMN, but I have no problem finding it for sale....?

Should Nmn capsules 💊 be kept in the fridge??

Isn’t NMN banned in America?

Some functional doctors are recommending to take NAD supplements - wonder why Dr Sinclair recommends MNM instead?

SO is it better NMN or NAD?

Oh hes back, Let me guess, hes wrote a new book...

Not selli g the stuff😂😂😂 he has his own company selling MMN ( MIB-626)

Physicist says that going near black holes slows time. If the astronaut was taking resveratrol it might slow it down even more. I wonder about that.

I was listening to this video and I kept wondering why didn’t I know Robert Downy Jr have a podcast? Like close your eyes and listen to when the host speaks

Of course maintaining and building muscle mass takes weight lifting. It's hard. Absolutely required after 50s. The good proven one is bodybuilding Anything else is... Cardio, cycling, running incurs muscle wasting. Cardio is not effective for weight/fat loss. Only diet is effective. Plus the injuries, broken ankle bones.

Easy for Dr. Sinclair to say "take NMN" when he gets pure NMN from his lab. The rest of us have to settle for retail supplements hoping they actually have NMN in the amounts advertised.

Most everyone knows you don’t sell NMN. However you want to turn it into a drug. The company, correct me if I’m wrong, is Biotech which you are directly associated with. 🤔

Did Sinclair want all NMN banned by the FDA, except the NMN made by his own company?

What brand is the safest and most effective of NMN

If NMN is beneficial in humans, why is David Sinclair spending a fair amount of money paying lawyers to stopping that getting to the general public? This is why I love Bryan Johnson.

How could I accept any information about longevity coming from people who use skin filters to hide their aging?

Title is wrong, says "MNM" and should say "NMN"

I took one dose of metformin- I got so sick from it- horrible gastroenteritis

i hope Dr. Sinclair has a change of mind on exercise and veganism.

What will reverse gray hair?

I feel like Dr. David is already bored talking about NMN...😂😂hearing each time same question: so what is actually mnm? Explain us😂😂😂

The best thing for age reversal is element 115.

I have Hashimotos and NMN increases body inflammation and flares me, tried a few brands. So not all is good with everyone. It seems to modulate my immune system enough to upset it.

How much did they pay you to mention metformin,Your kidding,The side effects of that alone makes me believe your being paid for that.A friend started taking metformin and he said he felt sick to his stomach and stopped taking it and then felt better.

The problem with having to go to a doctor is it's 100 times more expensive than over the counter.

I take 1000mg Metformin because my MD detected a pre-diabetes. Three years later, I am fine, but by now, I notice my muscles are a bit weaker although I take Vits B12, Folic Acid and Thiamine... I don’t think I am not protected…😊

attempting to understand the health effects of ingesting purified charcoal or lump charcoal they fed mice an incredibly large ammount in there diet extending there lives by double. the last mouse was still alive when they terminated it to end the study. in ancient history those who consumed this as well were known as the coal biters and the most healthy and strong of all

I would like to test the NMN on myself, can anyone tell me which company to buy it from? I'm a little skeptical about it

Critical Findings From 12 Key NMN “Anti-Aging” Studies by Dr. Brad Stanfield. You will find evidence there.

I took this for a month and have anti aged back into the only collection of dust with a conscience.

I don't know whether its his face for what, but he looks young

I'm not just saying that for the sake of it but honestly he's looking younger.

😲❤️🔥🔥🔥