Haha, so let me clarify: if we produce these antibodies in large quantities, we could have a serum that needs to be injected periodically. This serum targets and blocks IL-11, a molecule that increases and becomes problematic as we age, contributing to inflammation and fibrosis. Unlike genetic treatments, which are expensive and complex, this antibody treatment could be a more accessible option. While it won’t literally make a 60-year-old feel like they’re 20 again, it could significantly improve health by reducing age-related inflammation and damage. Additionally, this treatment could be a game-changer for those suffering from fibromyalgia and chronic pain, offering much-needed relief by addressing the underlying inflammatory processes. Nice
It increases with age in response to tissue iron accumulation. It does this to protect us from bacteria that tend to proliferate when exposed to iron. It may help regeneration in a lab, but in the real world, it'll compromise immunity.
@zeryphex Debatable. Probably not, or only minimally. The only way it would is that giving blood removes toxic metabolites the body takes years to clear, as well as damaged or glycated proteins. If these glycated or damaged proteins are replaced efficiently, they could transport and normalize iron to some extent. With age, these proteins are replaced less efficiently. Blood donation does help the process, though.
I've been following life extension for a long time, and I think this one is important. Boehringer Ingelheim has an anti-IL-11 monoclonal antibody, currently known as BI 765423. There is a Phase 1 trial going on at the moment, which is just looking at pharmacokinetics in healthy males. It's still a long way from approval. That will require a Phase 2 and Phase 3 trials, which will take years. The paper described here is going to generate a lot of interest in this mab and any other possible IL-11 antagonists.
🎯 Key points for quick navigation: 00:00 *🧬 Introduction to IL-11: A less-studied cytokine, profibrotic, anti-regenerative, and pro-inflammatory.* 00:29 *🧪 Research Overview: IL-11 found highly upregulated in fibrosis-related conditions.* 01:39 *🧹 Kidney Regeneration: IL-11 inhibition leads to kidney function restoration in mice.* 02:08 *🔬 Epithelial Regeneration: IL-11 inhibition promotes epithelial cell-driven kidney regeneration.* 02:22 *🧩 IL-11 and Inflammation: IL-11 induces pro-inflammatory responses in kidney fibroblasts.* 02:50 *⏳ IL-11 and Aging: IL-11 stimulates a pathway leading to aging and cellular senescence.* 03:18 *🔄 Pathway Activation: IL-11 activates ERK, leading to inhibition of LKB1 and activation of mTOR.* 04:12 *🧬 Aging Gene: LKB1 is an important gene in aging; its gain of function is beneficial.* 04:52 *🧪 IL-11 in Senescence: IL-11 inhibition reverses cellular senescence and inflammation.* 05:44 *📉 Age-Related Increase: IL-11 levels rise with age in various organs, activating aging pathways.* 06:40 *🧬 Genetic Study: IL-11 receptor knockout mice show significantly younger biological age.* 07:50 *🐭 Mouse Study: IL-11 inhibition reduces frailty and maintains muscle mass in aged mice.* 09:12 *🧠 Brain Atrophy: IL-11 inhibition reduces brain atrophy in aging mice.* 10:36 *💊 Potential Therapy: IL-11 inhibition as a single agent could target multiple aging pathways with limited toxicity.* Made with HARPA AI
Il-11 levels increase in response to age related accumulation of iron. It does this to stave off iron loving bacteria. If you block IL-11 you do help with regeneration, but you compromise immunity. It'll work in a lab but not in the real world. Better off lowering age related iron accumulation.
Hello - what is good iron or ferritin level in blood so to prevent high production of it-11? Others saying too iron bad from standpoint of bacteria likes and also is an oxidant. But then need iron in red blood cell for carrying oxygen to all cells. So delicate balance and probably becomes altered with age.
What you want to do is take Copper, more than might be generally thought to help reduce iron, look into the Cu-re book by Morley Robbins, you can find videos covering it Copper mobilizes iron and once you take Copper you poop out excess iron fast! Heard one woman taking 60mg of Copper without ill effect and while that seems exceedingly aggressive with Vitamin A and Magnesium to use it and make Ceruloplasmin.
@@jonathanberry1111 The real problem is decreases in levels of transferrin and lactoferrin as well as these little protein envelopes that transport iron with age. Copper helps a little bit, though.
@moniryousefian8782 If I I knew that I'd be a rich man. Lactoferrin and Transferrin levels help transport it in a way that cells utilize it properly without buildup. Restoring the levels of it with age is a challenge. Women's milk contains massive amounts for babies, and Lactoferrin does more than iron transport. it's a master guardian of the genome.
I will just keep my balanced diet with low food and industrial trash...exercise until the end. No easy industrial answer. If you search the nature has anti everything. Old knowledge.
Inhibition of iL-11 will be problematic because it can directly affect the somatic cells and blood cells. Also, this is a crucial cytokine and receptor needed for maintaining fertility.
In my attempt in living longer, I live in a boring room and nothing else to do. The loneliness kills me a bit. I think ageless people in the future think suicide might be a common way to die if they can't die from old age or they get sick and tired of existing. I want to know if there's a way to get rid of dying from loneliness? I just want to be alone in my room for long durations of time because I know this is what will happen to all of us at some point in life. Loneliness is a real killer. I can still survive boredom which I can overcome.
Inhibition of iL-11 will be problematic because it can directly affect the somatic cells and blood cells. Also, this is a crucial cytokine and receptor needed for maintaining fertility.
Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone Metastases >>Moreover, in an in vivo experiment, a preparation containing the essential turmeric oils in addition to the standard Curcumin demonstrated a higher bioavailability, a prerequisite to be adsorbed following the ingestion, resulting in upregulation of the expression of IL-10 and IL-11. Taken together, this preclinical and clinical evidence allow considering Curcumin and its derivatives as a tool to potentiate the chemotherapeutic agents against cancer.
@@DCGreenZone - but then much other research having turmeric good for preventing brain issues. And many other studies having benefits of turmeric for prevention of other body issues. Now here research indicating bad as increases il-11.
The only drawback of NMN supplementation found so far is fibrosis of kidneys in elderly mice. If anti-IL-11 stuff can "undo" kidney fibrosis, us elderly mice can go back to taking NMN without worry.
What happened to eating well, drinking good water and enjoying life to the end... and even, enjoying the end. Isn't that enough? I'll update you on my 236th year all. Single treatments ALWAYS lead to larger problems that leads to more questions. Let's be happy with what we're given, huh?
@@viracocha2021 I still think the same, I wouldn't use that (nor Metformin) before I reach 60 years, I believe that (before that age) the molecules from Astragalus are a better way to age well thanks to their effects on the lengthening of the telomeres, without affecting tissue growth
>>Moreover, in an in vivo experiment, a preparation containing the essential turmeric oils in addition to the standard Curcumin demonstrated a higher bioavailability, a prerequisite to be adsorbed following the ingestion, resulting in upregulation of the expression of IL-10 and IL-11 [108]. Taken together, this preclinical and clinical evidence allow considering Curcumin and its derivatives as a tool to potentiate the chemotherapeutic agents against cancer.
high quality/dose Omega 3 fish oils with both DHA and EPA will also inhibit IL-11 and can be gotten in a supplement cap. add to that Donotage NMN, apigenin/fisetin/quercetin and grapeseed extract and the years will fly back?
I too see omega 3 lowers per some studies. Great if could do studies like this with omega having two mice groups and then look at markers in 100 days. Did u find any studies like this?
I take metformin albeit low dose (0.5 g), rapamycin (6 mg once a week) and Dasatinib+Quercein (two 3 day cycles once ever y4 months) but unlike these mice, I don't lose any weight - in fact I gained a lot of weight although it is my bad eating habits and lifestyle, but I was hoping the combination treatment would combat that.
Hello - maybe want to drop metformin- why taking metformin - newer research saying more issues with it. Think too the NIH work saying no increase in lifespan for mice with metformin. With your weight gain - why not add glp1 agonist?
You can't get it. It is made in the lab by creating antibodies with rats or mice by injecting them with IL-11 and then isolating these antibodies and if needed humanize them. Just like other antibodies.
Tocilizumab (Actemra): This IL-6 receptor inhibitor has been shown to have effects on IL-11 as well. Sarilumab (Kevzara): Another IL-6 receptor inhibitor that may also influence IL-11 levels1. The antibody injection is obviously the best way to do this. This basically the injection of lab made drug (basically proteins) that target IL-11 and nothing else. No side effects.
He forgot to tell us about the lifespan of people affected by Craniosynostosis and Dental Anomalies (CRSDA), who don't produce any IL-11 due to a genetic disorder He also greatly diminished the malformations that come with no IL11. Something tells me this guy is over selling his research.
Hello - i think from presentation maybe saying need some during early development but then need to prevent in older age. Do u think maybe Il11 is downstream marker and need to correct more upstream where real issue is?
This is the early phase of research. Inhibition of iL-11 will be problematic because it can directly affect the somatic cells and blood cells. Also, this is a crucial cytokine and receptor needed for maintaining fertility.
@@Your-L0ver again I don’t think any reasonable person would suggest eliminating the cytokine entirely . Only regulating inactivity many of these factors do you become dreg, ululated and overactive with age. Though you are, of course, right to point out that anything we can have too much of we can have too little love as well that’s generally the case in biology
Reduction of IL-11, rather than complete blockage of it, may be the best course. Or blocking it, but not all the time. Like two weeks on, two weeks off, or some other pattern on/off.
Blocking IL11 production involves too much. They're blocking the RECEPTOR, it's much simpler. (Idk about this outfit, not sure if their supplements do anything 🤔).
It means metformin increases ampk (AMP-activated protein kinase) which promotes autophagy, inhibits mtor to some degree, it basically tells your body your in a fasted state more the being in a fed state. That in itself has been shown to be anti aging and basically part of the combination therapy. I'm not sure if any AMPK activator will do the same thing like berberine because I have no clue what LKB1 is. It just means if you taking metformin, your helping AMPK but the biggest driver here might be ERK as it also drives that pathway.
@BadWolf-bw6ik I know metformin helps to activate AMPK and inhibit mTOR. But do metformin decrease IL11 or it increase it? In the diagram, other drugs have a down arrow, but metformin has an up arrow. So do metformin increase IL11?
@user-ys4rl7xm6t I believe he said, although he jumbles his words awfully here, even the transcript is goofed up saying whole part when he meant combination, then saying decreasing (I think he was thinking of il-11 before running through the list), Hence "so with anti il-11 you get a combination effect activating APK decreasing mtor and inhibiting senescence with a single agent." The list for Anti-IL11 is not showing the effect on IL11 here just that it has the same effect as all these other components and as he said they have a cumulative effect, I imagine they all lower IL11 but the figure is just showing both metformin and anti-IL11 activate AMPK. That is my understanding sorry. I would infer from that if Anti-IL11 lowers IL11 then metformin will also due to activating AMPK.
Slide said metformin increases LKB1 (good for longevity). Earlier discussion said IL-11 inhibits LKB1, which may be part of why IL-11 seems bad for longevity. If the metformin counteracts some of the inhibition of LKB1 by IL-11, then that would seem to be good for longevity. I’m not done watching the video yet, but I’m wondering what else can stimulate LKB1. Maybe don’t need an IL-11 blocker, if you can just undo its effect on LKB1🤷♂️
If women are still fertile, probably young enough that they don’t really need to worry about blocking IL-11 yet. Or if they are young but don’t want to have children yet, infertility (if reversible) could be a bonus.
Once we're in our 50s and beyond, I'm not sure how many of us are worrying about maintaining our fertility. At age sixty, I'm a lot more worried about withering and dying then I am about trying to have more kids 🤣
And my guess is that whatever reduces visceral fat, will also help prevent thymus from turning into a fat blob with age, and so keep you younger longer.
That is English. They're saying that by blocking IL 11 it turns off inflammation and starts preparing the body. There was a little more to it than that but I think that's simple enough for you to understand without taking classes.
Great to live long from standpoint - do find alien live in galaxy, when to setup on mars, when driverless cars take off, too when flying cars. How about seeing and helping with grandkids and there kids?
@@michael-qp9xd Thankfully, I have no kids. Happy I didn't bring anyone into this world of staggering hate and racism. Growing up I never saw it, especially the utter contempt and complete lack of respect between older (X and Baby Boomers) and young (Millennials and Z for now). The racism that has been stoked since Obama was in office is unreal. One World gov isnt that far away(in your child or grandchilds lifetime). With that comes digital currency, social credit scores (already implemented in some countries). If you haven't read up on transhumanism, do yourself a favor and dig deep. Its real and on the horizon. Kiss whatever freedoms you think you have now goodbye. I could keep going but will leave it at that. I sincerely do wish you and your family all the best though and pray I am 100% wrong.
I mean, that sounds great in a way but what’s your natural expiration date?? For most of human history, life expectancy it was a fraction of what it is now. You grew up in his Society with access to modern medicine, vaccination, etc. The point is what do you call? Natural is always implicitly a choice. If nature is truly indifferent, it honestly doesn’t give a damn how long we live or what we do so we define and redefine normal as we go, just as nature itself always does.
I once was in south Louisiana on a field trip with friends and a back woods gentleman of Cajun heritage, I was picking a plant I thought was safe to eat, this gentleman told me to throw it away, I could barely understand him but i figure he saved my life that day. Screw English language fascists
