Fabulous presentation. Science based and to the point. I’ve suspected IR as a root cause of my many issues over the last 4-5 yrs however A1c/fasting sugar was always in line and issue dismissed by physicians. Now I’m more sensitive than ever to glucose/fructose and going through occasional odd waves of glycogen release from the liver disrupting sleep in ‘waves of energy’ through the night. Ie. fatty liver clogged. Also hpalps more prevalent now after eating. Not one doc nor even a functional med practitioner mentioned the Kraft test to me. Thank you so much for your presentation and clarifying a link between insulin response and CVD. Fantastic!
Thanks Ivor, nice summary and info, as can use this in my own research. Eliminating IR and supporting all the microbiomes living in/on humans is priority .. 70 Going On 100 … the Centenarian Diet … maybe 70 Going On 128 … the Hayflick Limit … or if a fan of Ray Kurzweil … then this is all a Moot Point.
I wish i was able to compose myself as well as Ivor can, it's truly masculine & respectable. No nonsense, straight facts and information for the benefit of humanity.
Beauty's in the eye of the beholder. Musicality's in the ear of the listener/perceiver. Ceaseless, unending tolerance of accent should be the rule of law everywhere!
My Dr. Refuses to give me an Insulin resistance test......... I even tried to explain to her when she asked me "why"... first I told her my mother had developed type 2 and then I went on to tell her how useless I thought a straight glucose test was.... its like testing to see if the fire has burned the house down yet, instead of preventing the fire in the first place, not to mention that if you wait for your glucose to rise into type2 territory it does damage on the way there if you have insulin resistance!!..... WHY would she be soooo resistant to this test when the facts are so damning?
The medical industrial complex's failure to properly research and diagnose and treat diet and microbiome and sleep and vital nutritional deficiency issues (including those related to Vitamin D3 and Vitamin K2 and Magnesium deficiencies as well as iatrogenic prescription medication usage) is a major reason why psychiatric iatrogenesis is a primary contributor to the third leading cause of death in the U.S. (which is iatrogenesis in general). If the U.S. spent just a fraction of the over $40 billion each year it spends just on iatrogenic psychiatric drugs alone, for properly researching the issues discussed in this and related RU-vid presentations we would probably, Lord willing, achieve an absolute revolution in medical efficacy improvement and iatrogenesis reduction. Thomas Steven Roth, MBA, MD Christian Minister for Biblical Medical Ethics, and therefore, Scientific and Religious Refugee from the Clinical Practice of Psychiatric Standards of Care
hi I practice in Canada and started doing insulin levels on patients with larger waists high triglycerides low hdl bp elevated often not by much but the provincial lab phoned and told me to stop as the test was aimed at endocrinologists and it cost $12 so I asked how many endocrinologists treated heart trouble he was not impressed.Cardiologists dont look at insulin resistance here and if I report high coronary calcium scores they restratify their lipid doses
As a patient in Canada, the lack of proper testing with numerous conditions is terrible in a supposedly developed country. Good doctors often have their hands tied by labs, and the pharmaceutical ‘industry’ and the big-wigs making the rules. When I’d ask numerous doctors what diet they’d recommend, and not one was able to tell my good advice. Only by accident did I happen upon low carb. I lost 50 years of my 60 years doing things wrong because the Canada Food Guide was all I could find or the calories in-calories out, and eat less-move more idiocy. I found through a book I found in Safeway by Jonny Bowden describing different low carb books. Through him I finally found “Diabetes Solution” by Dr. Richard K. Bernstein, Diabetologist. So sad how many others don’t have this information and are told blood sugars of 7+++ are perfectly fine. Optimal: My goal 4.6 mmol/l 83 mg/dl
our early human ancestors that migrated out of Africa about(10000 years ago) developed the ability to become insulin resistant by combining Fats and sugars . (Randle cycle) this then allowed them to store fat and survive the winter when food was scarce. During the winter months they became insulin sensitive and the cycle would start all over again... Now we have the standard American diet which allows us to combine Fats and sugars all the time so our body wants to store fat as it is in a continuous state of insulin resistance as demonstrated by Joseph kraft
Yep, thats corret. Insulin resistance is not a disease and is only one pathway to artery disease. The other pathway is Cholestrol/Triglyceride pathway abnormal lipid ratios. They can be related but not always.
15:00 - regarding cellular structure to glucose/insulin response, I’ve tested this by using different cooking protocols with high starch foods and discovered that if I boil sweet potatoes for just 30-40 seconds my postprandial glucose response stays below 7.8mmol/L, whereas if I boil them for a couple of minutes it soars way above this level. The reason is less breakdown of the cellular structure results in a more even/delayed release of cell contents. Incidentally, after 30-40 secs sweet potatoes are very crunchy, but perfectly edible...just not as enjoyable!
CAC score: I have patients above 50 yo with high score ( over 500) that I did a coronography: NORMAL coronography. All Calcium was in the extravascular tissue .... Not a single plaque... CAC score is a Poor predictor for people over 50.
So Ivor, you present the "Gut" as ground zero. What covers what you are calling the "gut"? I no longer have a large intestine. How does this fact effect or interact with IR ? Thanks.
I'm reading Dr. Joseph Kraft's "Diabetes Epidemic and You" at this moment. OMG!! Buy the book and read it. Then, buy a copy for your doctor, dietician, and local college's library. This book is a must-read for absolutely everyone!!!!
The book begins with a lie: Our bodies need cholesterol. It is essential for our very existence. Without it, we are no more. It consists of a low-density lipoprotein (LDL) and a high density lipoprotein component. An anatomic pathology for cholesterol does not exist. A pathologic relationship of cholesterol per se to arteriosclerosis is lacking. Cholesterol among several lipids is a co-participant in lipid deposition in arterial vessels damaged by hyperinsulinemia (insulin resistance) in the production of athero-arteriosclerosis. Joseph R. Kraft. Diabetes Epidemic & You (Kindle-Positionen207-211). Trafford Publishing. Kindle-Version. Why would anyone read a book which begins with a lie?
@@erastvandoren Nice firm statement again. I hardly beleve you have anu relation to the academia, otherwise you should refresh your Cell Biology and Organic Chemistry 101.:) Cos, you seem completely skipped those lectures at all.
Ivor, please be aware that I respect you enormously and listen closely to every word you say, did you say that glucose and fat, together, are very bad, could you talk more in depth about that.
Has anyone looked into any possible association or positive correlation between serum calcium and CAC scores or are they occuring due to entirely independant mechanisms?
It's not a myth. The food pyramid is modeled on the diet of primative populations who live the longest and get none of the degenerative diseases of modern soceity.
Why is it that we assume the 20% are healthy , maybe the real truth is that only a narrow portion of the population can tolerate glucose and from a evolutionary perspective that makes sense.
Yes, it seems that only a very small percentage of the population can tolerate significant amounts of glucose over long periods of time. Yet is seems that many people's bodies are still handling the sugar load in their 20s, but they system becomes more strained over time. As more and more people have been raised on higher and higher levels of sugar and starch from and earlier and earlier age, you are right: more and more people are obviously unhealthy at younger and younger ages; way before they reach their 20s. Infants given sugar water iin hospitals after birth... weaned onto fruit juice... started on refined grain cereals as their first solid foods... they are given bread to chew on when they teeth. As they grow, many are fed sugaf & starch breakfast cereals, they get more 'healthy' fruit juice, lots of bananas, apples, grapes and other high fructose fruits... peanut butter & jelly sandwiches... Couple that with a lack of healthy fats, and sometimes even quality proteins in their food, and the real wonder is that even more of these people are not becoming even sicker even sooner than they are!
It is a sad situation that lots of people missing the point. I don't think this video is about demonizing carb but refined carbs and sugars which are devoid of real nutrition and fiber. refined carb and sugar spike sugar too much insulin and force us eat more frequent, and spiking too much insulin too often cause insulin resistance while natural whole foods don't.
Other talks posted by Low Carb Down Under cover that, some in more depth than others. Basically, insulin drives excess sugar (from sugar or starches consumed) out of the blood and into the tissues. The blood can hold about 1 tsp. The muscles can hold around 2,000 calories worth. The rest goes into fat cells. Frequent spikes of insulin can lead to 'overstuffing' of these cells, making them insulin resistant. And/or they become desensitized due to near constant high insulin levels caused by frequent intake of food and calorie containing beverages. Protein also triggers insulin release, but not nearly as much as sugar or starch (which is just sugar linked together, that quickly turns to sugar when eaten). Check out the other LCD videos for more detail.
You would have to eat an awful lot of table sugar for it to go straight into fat reserves. This has been demonstrated in many experiments, in fact blood glucose is always improved by carbs, it allows the insulin to regulate properly
Investigate fish oil, d3 and k2 in the mk-7 form. Inflammation fighting fat with fat soluble vitamins. The K2 apparently helps clean up arterial calcium.
I don't think you watched the whole video or understood it. What Ivor is saying is that pay attention to insulin resistance which is the elephant in the room. In fact, I heard Dr. Joseph Kraft betting to find cardiovascular issue without insulin resistance. instead of worrying about cholesterol worry about insulin resistance. there are people who have clean artery with too much cholesterol, but there is no one with hyperinsulinemia and clear artery. if you find one, you could get a prize., now you understand this research about how to reverse insulin resistance.
For oils, I only take virgin coconut oil (VCO) & (extra) virgin olive oil -- both are cold-pressed! Here in the Philippines, VCO is ubiquitous & relatively inexpensive.
The crux is “what causes insulin resistance”. Studies going back to the 1920s and 1930s show high dietary intake of fatty acids (aka fatty food) cause insulin resistance. We don’t even realise what a low fat diet is these days is. It’s less than 15% of calories from fat. Probably 90% of people eating Western diets get no where near that low fat intake. Food for thought. The healthiest populations in the world get up to 80% of calories from starchy carbs, so perhaps we need a re-think here. Today’s obsession with low carb is only treating or ameliorating the symptoms of IR not addressing the cause perhaps? 🤔
It's not the end of the world. Glucose by itself isn't a major issue in reasonable amounts - so long as insulin resistance isn't in play. Fructose (specifically in added sugar) is a bigger problem, as it fast-tracks fatty liver disease, but typical glucose (starch), so long as it's not consumed all day long, won't be the end of the world. Pre-1978, folks were eating bread, pasta, and grains, but obesity and diabetes weren't what they are today. Added sugars and removal of fiber are what tipped the scale. Glucose alone is a concern in excess, and should be minimized if insulin resistance is already occurring. But if you're metabolically healthy, a baguette, a potato, or a bowl of rice a day won't be the thing that makes you diabetic. Sugars are the keystone.
I am doing the thing NOBODY has the God Complexity Complex balls to do: make the entire body a 3D dynamic math problem. And engineering a REAL Zombie Virus is the challenge that amuses me. Government, keep me away from a CRISPR. I will just Prion and on until I get it.
There are many doctors who used to give the standard low-fat high-carb dietary advice but became frustrated that it wasn't working for their patients, & also in some cases, for themselves. When they tried low-carb high fat, they saw excellent results. e.g. Ken Berry, David Unwin, Paul Mason.
It's likely true but what he doesn't tell you is there are also other pathway that can explain it. It's a whole bunch of pathways and how the body react with saturated fat, sugar and unsaturated fat. What he doesn't want to tell is the outcome. Where is the outcome of eating these specific food contain saturated fat, sugar, unsaturated fat when they are eaten by the same amount of calories. U think we haven't tested that? OBJECTIVE Nonalcoholic fatty liver disease (i.e., increased intrahepatic triglyceride [IHTG] content), predisposes to type 2 diabetes and cardiovascular disease. Adipose tissue lipolysis and hepatic de novo lipogenesis (DNL) are the main pathways contributing to IHTG. We hypothesized that dietary macronutrient composition influences the pathways, mediators, and magnitude of weight gain-induced changes in IHTG. RESEARCH DESIGN AND METHODS We overfed 38 overweight subjects (age 48 ± 2 years, BMI 31 ± 1 kg/m2, liver fat 4.7 ± 0.9%) 1,000 extra kcal/day of saturated (SAT) or unsaturated (UNSAT) fat or simple sugars (CARB) for 3 weeks. We measured IHTG (1H-MRS), pathways contributing to IHTG (lipolysis ([2H5]glycerol) and DNL (2H2O) basally and during euglycemic hyperinsulinemia), insulin resistance, endotoxemia, plasma ceramides, and adipose tissue gene expression at 0 and 3 weeks. RESULTS Overfeeding SAT increased IHTG more (+55%) than UNSAT (+15%, P < 0.05). CARB increased IHTG (+33%) by stimulating DNL (+98%). SAT significantly increased while UNSAT decreased lipolysis. SAT induced insulin resistance and endotoxemia and significantly increased multiple plasma ceramides. The diets had distinct effects on adipose tissue gene expression. CONCLUSIONS Macronutrient composition of excess energy influences pathways of IHTG: CARB increases DNL, while SAT increases and UNSAT decreases lipolysis. SAT induced the greatest increase in IHTG, insulin resistance, and harmful ceramides. Decreased intakes of SAT could be beneficial in reducing IHTG and the associated risk of diabetes.
